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Results: 1 to 20 of 37

1.

Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists.

Xiao HY, Balog A, Attar RM, Fairfax D, Fleming LB, Holst CL, Martin GS, Rossiter LM, Chen J, Cvjic ME, Dell-John J, Geng J, Gottardis MM, Han WC, Nation A, Obermeier M, Rizzo CA, Schweizer L, Spires T Jr, Shan W, Gavai A, Salvati ME, Vite G.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4491-5. doi: 10.1016/j.bmcl.2010.06.034. Epub 2010 Jun 10.

PMID:
20584610
[PubMed - indexed for MEDLINE]
2.

Discovery of BMS-641988, a novel and potent inhibitor of androgen receptor signaling for the treatment of prostate cancer.

Attar RM, Jure-Kunkel M, Balog A, Cvijic ME, Dell-John J, Rizzo CA, Schweizer L, Spires TE, Platero JS, Obermeier M, Shan W, Salvati ME, Foster WR, Dinchuk J, Chen SJ, Vite G, Kramer R, Gottardis MM.

Cancer Res. 2009 Aug 15;69(16):6522-30. doi: 10.1158/0008-5472.CAN-09-1111. Epub 2009 Aug 4.

PMID:
19654297
[PubMed - indexed for MEDLINE]
Free Article
3.

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists.

Salvati ME, Balog A, Shan W, Rampulla R, Giese S, Mitt T, Furch JA, Vite GD, Attar RM, Jure-Kunkel M, Geng J, Rizzo CA, Gottardis MM, Krystek SR, Gougoutas J, Galella MA, Obermeier M, Fura A, Chandrasena G.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1910-5. doi: 10.1016/j.bmcl.2008.02.006. Epub 2008 Feb 8.

PMID:
18291644
[PubMed - indexed for MEDLINE]
4.

The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgens.

Schweizer L, Rizzo CA, Spires TE, Platero JS, Wu Q, Lin TA, Gottardis MM, Attar RM.

BMC Cell Biol. 2008 Jan 24;9:4. doi: 10.1186/1471-2121-9-4.

PMID:
18218096
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Pharmacological characterization of postjunctional alpha-adrenoceptors in human nasal mucosa.

Corboz MR, Rivelli MA, Varty L, Mutter J, Cartwright M, Rizzo CA, Eckel SP, Anthes JC, Hey JA.

Am J Rhinol. 2005 Sep-Oct;19(5):495-502.

PMID:
16270605
[PubMed - indexed for MEDLINE]
6.

Identification of novel functional inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3).

Spires TE, Fink BE, Kick EK, You D, Rizzo CA, Takenaka I, Lawrence RM, Ruan Z, Salvati ME, Vite GD, Weinmann R, Attar RM, Gottardis MM, Lorenzi MV.

Prostate. 2005 Oct 1;65(2):159-70.

PMID:
15924334
[PubMed - indexed for MEDLINE]
7.

Identification of a novel class of androgen receptor antagonists based on the bicyclic-1H-isoindole-1,3(2H)-dione nucleus.

Salvati ME, Balog A, Wei DD, Pickering D, Attar RM, Geng J, Rizzo CA, Hunt JT, Gottardis MM, Weinmann R, Martinez R.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):389-93.

PMID:
15603960
[PubMed - indexed for MEDLINE]
8.

Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.

Salvati ME, Balog A, Shan W, Wei DD, Pickering D, Attar RM, Geng J, Rizzo CA, Gottardis MM, Weinmann R, Krystek SR, Sack J, An Y, Kish K.

Bioorg Med Chem Lett. 2005 Jan 17;15(2):271-6.

PMID:
15603938
[PubMed - indexed for MEDLINE]
9.

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.

Balog A, Salvati ME, Shan W, Mathur A, Leith LW, Wei DD, Attar RM, Geng J, Rizzo CA, Wang C, Krystek SR, Tokarski JS, Hunt JT, Gottardis M, Weinmann R.

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6107-11.

PMID:
15546739
[PubMed - indexed for MEDLINE]
10.

Pharmacological characterization of alpha 2-adrenoceptor-mediated responses in pig nasal mucosa.

Corboz MR, Varty LM, Rizzo CA, Mutter JC, Rivelli MA, Wan Y, Umland S, Qiu H, Jakway J, McCormick KD, Berlin M, Hey JA.

Auton Autacoid Pharmacol. 2003 Aug;23(4):208-19.

PMID:
15084187
[PubMed - indexed for MEDLINE]
11.

Functional TRPV4 channels are expressed in human airway smooth muscle cells.

Jia Y, Wang X, Varty L, Rizzo CA, Yang R, Correll CC, Phelps PT, Egan RW, Hey JA.

Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L272-8. Epub 2004 Apr 9.

PMID:
15075247
[PubMed - indexed for MEDLINE]
Free Article
12.

Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on tachykinergic bronchomotor responses in the guinea-pig.

Corboz MR, Fernandez X, Rizzo CA, Tozzi S, Monahan ME, Hey JA.

Auton Autacoid Pharmacol. 2003 Feb;23(1):79-93.

PMID:
14565542
[PubMed - indexed for MEDLINE]
13.

Development and potential utility of dual and triple NK receptor antagonists.

Rizzo CA, Anthes JC, Corboz MR, Chapman RW, Shih NY, Reichard GA, Ng KJ, Hey JA.

Curr Top Med Chem. 2003;3(12):1410-22. Review.

PMID:
12871172
[PubMed - indexed for MEDLINE]
14.

Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687).

McLeod RL, Rizzo CA, West RE Jr, Aslanian R, McCormick K, Bryant M, Hsieh Y, Korfmacher W, Mingo GG, Varty L, Williams SM, Shih NY, Egan RW, Hey JA.

J Pharmacol Exp Ther. 2003 Jun;305(3):1037-44. Epub 2003 Mar 20.

PMID:
12649305
[PubMed - indexed for MEDLINE]
Free Article
15.

Coordination of histamine H3 receptor antagonists with human adrenal cytochrome P450 enzymes.

Yang R, Hey JA, Aslanian R, Rizzo CA.

Pharmacology. 2002 Nov;66(3):128-35.

PMID:
12372902
[PubMed - indexed for MEDLINE]
16.

Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.

Ting PC, Lee JF, Shih NY, Piwinski JJ, Anthes JC, Chapman RW, Rizzo CA, Hey JA, Ng K, Nomeir AA.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2125-8.

PMID:
12127519
[PubMed - indexed for MEDLINE]
17.

Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor.

Billah MM, Cooper N, Minnicozzi M, Warneck J, Wang P, Hey JA, Kreutner W, Rizzo CA, Smith SR, Young S, Chapman RW, Dyke H, Shih NY, Piwinski JJ, Cuss FM, Montana J, Ganguly AK, Egan RW.

J Pharmacol Exp Ther. 2002 Jul;302(1):127-37.

PMID:
12065709
[PubMed - indexed for MEDLINE]
Free Article
18.

The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness.

Rizzo CA, Yang R, Greenfeder S, Egan RW, Pauwels RA, Hey JA.

J Allergy Clin Immunol. 2002 Mar;109(3):404-9.

PMID:
11897983
[PubMed - indexed for MEDLINE]
19.

Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel.

Jia Y, Wang X, Aponte SI, Rivelli MA, Yang R, Rizzo CA, Corboz MR, Priestley T, Hey JA.

Br J Pharmacol. 2002 Feb;135(3):764-70.

PMID:
11834624
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus.

Ruck LM, Rizzo CA, Anthes JC, Eckel S, Egan RW, Cuss FM, Hey JA.

Life Sci. 2001 May 11;68(25):2825-34.

PMID:
11432448
[PubMed - indexed for MEDLINE]

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