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Results: 1 to 20 of 54


Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise.

Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD, Screen HR.

J Orthop Res. 2015 Jun;33(6):889-97. doi: 10.1002/jor.22879.


Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.

Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD, Screen HR.

Scand J Med Sci Sports. 2014 Dec 30. doi: 10.1111/sms.12333. [Epub ahead of print]


Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level.

Shepherd JH, Riley GP, Screen HR.

J Mech Behav Biomed Mater. 2014 Oct;38:163-72. doi: 10.1016/j.jmbbm.2014.06.005. Epub 2014 Jul 4.


Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons.

Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HR.

Acta Biomater. 2014 Jul;10(7):3217-24. doi: 10.1016/j.actbio.2014.04.008. Epub 2014 Apr 18.


Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading.

Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HR.

J R Soc Interface. 2014 Jan 8;11(92):20131058. doi: 10.1098/rsif.2013.1058. Print 2014 Mar 6.


Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour.

Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP, Screen HR.

Proc Inst Mech Eng H. 2014 Jan;228(1):49-59. doi: 10.1177/0954411913509977. Epub 2013 Nov 27.


Cyclical strain modulates metalloprotease and matrix gene expression in human tenocytes via activation of TGFβ.

Jones ER, Jones GC, Legerlotz K, Riley GP.

Biochim Biophys Acta. 2013 Dec;1833(12):2596-607. doi: 10.1016/j.bbamcr.2013.06.019. Epub 2013 Jul 2.


Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return.

Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD, Screen HR.

Acta Biomater. 2013 Aug;9(8):7948-56. doi: 10.1016/j.actbio.2013.05.004. Epub 2013 May 10.


GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery.

Legerlotz K, Riley GP, Screen HR.

Acta Biomater. 2013 Jun;9(6):6860-6. doi: 10.1016/j.actbio.2013.02.028. Epub 2013 Feb 24.


MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction.

Wilkinson JM, Davidson RK, Swingler TE, Jones ER, Corps AN, Johnston P, Riley GP, Chojnowski AJ, Clark IM.

Biochim Biophys Acta. 2012 Jun;1822(6):897-905. doi: 10.1016/j.bbadis.2012.02.001. Epub 2012 Feb 9.


Increased expression of IL-6 family members in tendon pathology.

Legerlotz K, Jones ER, Screen HR, Riley GP.

Rheumatology (Oxford). 2012 Jul;51(7):1161-5. doi: 10.1093/rheumatology/kes002. Epub 2012 Feb 15.


Changes in matrix protein biochemistry and the expression of mRNA encoding matrix proteins and metalloproteinases in posterior tibialis tendinopathy.

Corps AN, Robinson AH, Harrall RL, Avery NC, Curry VA, Hazleman BL, Riley GP.

Ann Rheum Dis. 2012 May;71(5):746-52. doi: 10.1136/annrheumdis-2011-200391. Epub 2012 Jan 12.


Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes.

Legerlotz K, Jones GC, Screen HR, Riley GP.

Scand J Med Sci Sports. 2013 Feb;23(1):31-7. doi: 10.1111/j.1600-0838.2011.01410.x. Epub 2011 Nov 3.


Specimen dimensions influence the measurement of material properties in tendon fascicles.

Legerlotz K, Riley GP, Screen HR.

J Biomech. 2010 Aug 26;43(12):2274-80. doi: 10.1016/j.jbiomech.2010.04.040. Epub 2010 May 18.


The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.

Corps AN, Jones GC, Harrall RL, Curry VA, Hazleman BL, Riley GP.

Matrix Biol. 2008 Jun;27(5):393-401. doi: 10.1016/j.matbio.2008.02.002. Epub 2008 Apr 2.


The role of proteases in pathologies of the synovial joint.

Jones GC, Riley GP, Buttle DJ.

Int J Biochem Cell Biol. 2008;40(6-7):1199-218. doi: 10.1016/j.biocel.2008.01.024. Epub 2008 Feb 1. Review.


A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease.

Johnston P, Chojnowski AJ, Davidson RK, Riley GP, Donell ST, Clark IM.

J Hand Surg Am. 2007 Mar;32(3):343-51.


Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.

Jones GC, Corps AN, Pennington CJ, Clark IM, Edwards DR, Bradley MM, Hazleman BL, Riley GP.

Arthritis Rheum. 2006 Mar;54(3):832-42.


Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy.

Corps AN, Robinson AH, Movin T, Costa ML, Hazleman BL, Riley GP.

Rheumatology (Oxford). 2006 Mar;45(3):291-4. Epub 2005 Oct 11.


Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells.

Corps AN, Harrall RL, Curry VA, Hazleman BL, Riley GP.

Rheumatology (Oxford). 2005 Dec;44(12):1514-7. Epub 2005 Sep 7.

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