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Items: 1 to 20 of 38


ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancer.

Madhavan S, Gusev Y, Singh S, Riggins RB.

J Exp Clin Cancer Res. 2015 May 15;34:45. doi: 10.1186/s13046-015-0150-9.


Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate.

Schwartz-Roberts JL, Cook KL, Chen C, Shajahan-Haq AN, Axelrod M, Wärri A, Riggins RB, Jin L, Haddad BR, Kallakury BV, Baumann WT, Clarke R.

Cancer Res. 2015 Mar 15;75(6):1046-55. doi: 10.1158/0008-5472.CAN-14-1851. Epub 2015 Jan 9.


ERRβ splice variants differentially regulate cell cycle progression.

Heckler MM, Riggins RB.

Cell Cycle. 2015;14(1):31-45. doi: 10.4161/15384101.2014.972886.


NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.

Hu R, Warri A, Jin L, Zwart A, Riggins RB, Fang HB, Clarke R.

Mol Cell Biol. 2015 Jan;35(2):379-90. doi: 10.1128/MCB.00847-14. Epub 2014 Nov 3.


ERK/MAPK regulates ERRγ expression, transcriptional activity and receptor-mediated tamoxifen resistance in ER+ breast cancer.

Heckler MM, Thakor H, Schafer CC, Riggins RB.

FEBS J. 2014 May;281(10):2431-42. doi: 10.1111/febs.12797. Epub 2014 Apr 28.


Reconstruction of transcriptional regulatory networks by stability-based network component analysis.

Chen X, Xuan J, Wang C, Shajahan AN, Riggins RB, Clarke R.

IEEE/ACM Trans Comput Biol Bioinform. 2013 Nov-Dec;10(6):1347-58. doi: 10.1109/TCBB.2012.146.


In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers.

Gusev Y, Riggins RB, Bhuvaneshwar K, Gauba R, Sheahan L, Clarke R, Madhavan S.

Cancer Inform. 2013;12:31-51. doi: 10.4137/CIN.S10329. Epub 2013 Feb 13.


Identifying protein interaction subnetworks by a bagging Markov random field-based method.

Chen L, Xuan J, Riggins RB, Wang Y, Clarke R.

Nucleic Acids Res. 2013 Jan;41(2):e42. doi: 10.1093/nar/gks951. Epub 2012 Nov 17.


Trans-resveratrol boronic acid exhibits enhanced anti-proliferative activity on estrogen-dependent MCF-7 breast cancer cells.

Yenugonda VM, Kong Y, Deb TB, Yang Y, Riggins RB, Brown ML.

Cancer Biol Ther. 2012 Aug;13(10):925-34. doi: 10.4161/cbt.20845. Epub 2012 Aug 1.


Robust identification of transcriptional regulatory networks using a Gibbs sampler on outlier sum statistic.

Gu J, Xuan J, Riggins RB, Chen L, Wang Y, Clarke R.

Bioinformatics. 2012 Aug 1;28(15):1990-7. doi: 10.1093/bioinformatics/bts296. Epub 2012 May 17. Erratum in: Bioinformatics. 2014 Aug 1;30(15):2242.


Identifying cancer biomarkers by network-constrained support vector machines.

Chen L, Xuan J, Riggins RB, Clarke R, Wang Y.

BMC Syst Biol. 2011 Oct 12;5:161. doi: 10.1186/1752-0509-5-161.


G-DOC: a systems medicine platform for personalized oncology.

Madhavan S, Gusev Y, Harris M, Tanenbaum DM, Gauba R, Bhuvaneshwar K, Shinohara A, Rosso K, Carabet LA, Song L, Riggins RB, Dakshanamurthy S, Wang Y, Byers SW, Clarke R, Weiner LM.

Neoplasia. 2011 Sep;13(9):771-83.


Motif-guided sparse decomposition of gene expression data for regulatory module identification.

Gong T, Xuan J, Chen L, Riggins RB, Li H, Hoffman EP, Clarke R, Wang Y.

BMC Bioinformatics. 2011 Mar 22;12:82. doi: 10.1186/1471-2105-12-82.


Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer.

Clarke R, Shajahan AN, Wang Y, Tyson JJ, Riggins RB, Weiner LM, Bauman WT, Xuan J, Zhang B, Facey C, Aiyer H, Cook K, Hickman FE, Tavassoly I, Verdugo A, Chen C, Zwart A, Wärri A, Hilakivi-Clarke LA.

Horm Mol Biol Clin Investig. 2011 Mar;5(1):35-44.


Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.

Riggins RB, Mazzotta MM, Maniya OZ, Clarke R.

Endocr Relat Cancer. 2010 Aug 16;17(3):R213-31. doi: 10.1677/ERC-10-0058. Print 2010 Sep. Review.


IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.

Ning Y, Riggins RB, Mulla JE, Chung H, Zwart A, Clarke R.

Mol Cancer Ther. 2010 May;9(5):1274-85. doi: 10.1158/1535-7163.MCT-09-1169.


Multilevel support vector regression analysis to identify condition-specific regulatory networks.

Chen L, Xuan J, Riggins RB, Wang Y, Hoffman EP, Clarke R.

Bioinformatics. 2010 Jun 1;26(11):1416-22. doi: 10.1093/bioinformatics/btq144. Epub 2010 Apr 7.


BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.

Nehra R, Riggins RB, Shajahan AN, Zwart A, Crawford AC, Clarke R.

FASEB J. 2010 Jun;24(6):2040-55. doi: 10.1096/fj.09-138305. Epub 2010 Feb 12.


Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis.

Crawford AC, Riggins RB, Shajahan AN, Zwart A, Clarke R.

PLoS One. 2010 Jan 6;5(1):e8604. doi: 10.1371/journal.pone.0008604.

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