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  • The following term was not found in PubMed: 2006;38.
Nat Genet. 2006 Aug;38(8):873-5. Epub 2006 Jul 9.

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles.

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  • 1Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

Abstract

We screened individuals from 443 familial breast cancer pedigrees and 521 controls for ATM sequence variants and identified 12 mutations in affected individuals and two in controls (P = 0.0047). The results demonstrate that ATM mutations that cause ataxia-telangiectasia in biallelic carriers are breast cancer susceptibility alleles in monoallelic carriers, with an estimated relative risk of 2.37 (95% confidence interval (c.i.) = 1.51-3.78, P = 0.0003). There was no evidence that other classes of ATM variant confer a risk of breast cancer.

PMID:
16832357
[PubMed - indexed for MEDLINE]
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