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Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis.

Calvo-Álvarez E, Stamatakis K, Punzón C, Álvarez-Velilla R, Tejería A, Escudero-Martínez JM, Pérez-Pertejo Y, Fresno M, Balaña-Fouce R, Reguera RM.

PLoS Negl Trop Dis. 2015 Mar 31;9(3):e0003666. doi: 10.1371/journal.pntd.0003666. eCollection 2015 Mar.


Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

Reguera RM, Calvo-Álvarez E, Alvarez-Velilla R, Balaña-Fouce R.

Int J Parasitol Drugs Drug Resist. 2014 May 22;4(3):355-7. doi: 10.1016/j.ijpddr.2014.05.001. eCollection 2014 Dec.


Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery.

Balaña-Fouce R, Alvarez-Velilla R, Fernández-Prada C, García-Estrada C, Reguera RM.

Int J Parasitol Drugs Drug Resist. 2014 Aug 24;4(3):326-37. doi: 10.1016/j.ijpddr.2014.07.006. eCollection 2014 Dec. Review.


Trypanosomatids see the light: recent advances in bioimaging research.

Calvo-Álvarez E, Álvarez-Velilla R, Fernández-Prada C, Balaña-Fouce R, Reguera RM.

Drug Discov Today. 2015 Jan;20(1):114-21. doi: 10.1016/j.drudis.2014.09.012. Epub 2014 Sep 22. Review.


First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones.

Calvo-Álvarez E, Álvarez-Velilla R, Jiménez M, Molina R, Pérez-Pertejo Y, Balaña-Fouce R, Reguera RM.

PLoS Negl Trop Dis. 2014 Sep 4;8(9):e3075. doi: 10.1371/journal.pntd.0003075. eCollection 2014 Sep.


Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from Leishmania donovani with a mechanism different from that of camptothecin.

Carballeira NM, Montano N, Alvarez-Velilla R, Prada CF, Reguera RM, Balaña-Fouce R.

Mar Drugs. 2013 Sep 30;11(10):3661-75. doi: 10.3390/md11103661.


Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.

Prada CF, Álvarez-Velilla R, Díaz-Gozález R, Pérez-Pertejo Y, Balaña-Fouce R, Reguera RM.

PLoS One. 2013 Sep 2;8(9):e73565. doi: 10.1371/journal.pone.0073565. eCollection 2013.


The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq.

Rastrojo A, Carrasco-Ramiro F, Martín D, Crespillo A, Reguera RM, Aguado B, Requena JM.

BMC Genomics. 2013 Apr 4;14:223. doi: 10.1186/1471-2164-14-223.


Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect.

Prada CF, Alvarez-Velilla R, Balaña-Fouce R, Prieto C, Calvo-Álvarez E, Escudero-Martínez JM, Requena JM, Ordóñez C, Desideri A, Pérez-Pertejo Y, Reguera RM.

Biochem Pharmacol. 2013 May 15;85(10):1433-40. doi: 10.1016/j.bcp.2013.02.024. Epub 2013 Mar 1.


Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous leishmaniasis.

Calvo-Álvarez E, Guerrero NA, Alvarez-Velilla R, Prada CF, Requena JM, Punzón C, Llamas MÁ, Arévalo FJ, Rivas L, Fresno M, Pérez-Pertejo Y, Balaña-Fouce R, Reguera RM.

PLoS Negl Trop Dis. 2012;6(11):e1927. doi: 10.1371/journal.pntd.0001927. Epub 2012 Nov 29.


First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme.

Carballeira NM, Cartagena M, Li F, Chen Z, Prada CF, Calvo-Alvarez E, Reguera RM, Balaña-Fouce R.

Pure Appl Chem. 2012;84(9):1867-1875. Epub 2012 Apr 29.


A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity.

Prada CF, Alvarez-Velilla R, Diaz-González R, Prieto C, Pérez-Pertejo Y, Balaña-Fouce R, Reguera RM.

Biochim Biophys Acta. 2012 Dec;1820(12):2062-71. doi: 10.1016/j.bbagen.2012.09.005. Epub 2012 Sep 18.


2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani.

Carballeira NM, Cartagena M, Sanabria D, Tasdemir D, Prada CF, Reguera RM, Balaña-Fouce R.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6185-9. doi: 10.1016/j.bmcl.2012.08.019. Epub 2012 Aug 10.


Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis.

Balaña-Fouce R, Prada CF, Requena JM, Cushman M, Pommier Y, Álvarez-Velilla R, Escudero-Martínez JM, Calvo-Álvarez E, Pérez-Pertejo Y, Reguera RM.

Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. doi: 10.1128/AAC.00499-12. Epub 2012 Jul 30.


Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis.

Balaña-Fouce R, Calvo-Álvarez E, Álvarez-Velilla R, Prada CF, Pérez-Pertejo Y, Reguera RM.

Mol Biochem Parasitol. 2012 Feb;181(2):85-93. doi: 10.1016/j.molbiopara.2011.10.007. Epub 2011 Oct 20. Review.


Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.

Pérez-Pertejo Y, Alvarez-Velilla R, Estrada CG, Balaña-Fouce R, Reguera RM.

Parasitology. 2011 Aug;138(9):1082-92. doi: 10.1017/S0031182011000862.


The first total synthesis of the (±)-17-methyl-trans-4,5-methyleneoctadecanoic acid and related analogs with antileishmanial activity.

Carballeira NM, Montano N, Reguera RM, Balaña-Fouce R.

Tetrahedron Lett. 2010 Nov 24;51(47):6153-6155.


Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis.

Muleme HM, Reguera RM, Berard A, Azinwi R, Jia P, Okwor IB, Beverley S, Uzonna JE.

J Immunol. 2009 Dec 15;183(12):8068-76. doi: 10.4049/jimmunol.0803979. Epub .


Novel findings on trypanosomatid chemotherapy using DNA topoisomerase inhibitors.

Díaz-González R, Pérez-Pertejo Y, Prada CF, Fernández-Rubio C, Balaña-Fouce R, Reguera RM.

Mini Rev Med Chem. 2009 Jun;9(6):674-86. Review.


Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice.

Reguera RM, Balaña-Fouce R, Showalter M, Hickerson S, Beverley SM.

Mol Biochem Parasitol. 2009 May;165(1):48-56. doi: 10.1016/j.molbiopara.2009.01.001. Epub 2009 Jan 20.

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