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Reelin signaling is impaired in autism.
Fatemi SH, Snow AV, Stary JM, Araghi-Niknam M, Reutiman TJ, Lee S, Brooks AI, Pearce DA. Fatemi SH, et al. Biol Psychiatry. 2005 Apr 1;57(7):777-87. doi: 10.1016/j.biopsych.2004.12.018. Biol Psychiatry. 2005. PMID: 15820235
BACKGROUND: Autism is a severe neurodevelopmental disorder with genetic and environmental etiologies. ...The mRNAs for Reln and Dab-1 were reduced significantly whereas the mRNA for Reln receptor VLDLR was elevated significantly in superior frontal and cerebellar ar …
BACKGROUND: Autism is a severe neurodevelopmental disorder with genetic and environmental etiologies. ...The mRNAs for Reln an …
Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder.
Sánchez-Sánchez SM, Magdalon J, Griesi-Oliveira K, Yamamoto GL, Santacruz-Perez C, Fogo M, Passos-Bueno MR, Sertié AL. Sánchez-Sánchez SM, et al. Hum Mutat. 2018 Oct;39(10):1372-1383. doi: 10.1002/humu.23584. Epub 2018 Jul 26. Hum Mutat. 2018. PMID: 29969175
Although many rare heterozygous variants in the Reelin gene (RELN) have been identified in patients with autism spectrum disorder (ASD), most variants are still of unknown clinical significance. ...Here, we describe the identification and functional character …
Although many rare heterozygous variants in the Reelin gene (RELN) have been identified in patients with autism spectrum di …
Reelin and Neuropsychiatric Disorders.
Ishii K, Kubo KI, Nakajima K. Ishii K, et al. Front Cell Neurosci. 2016 Oct 18;10:229. doi: 10.3389/fncel.2016.00229. eCollection 2016. Front Cell Neurosci. 2016. PMID: 27803648 Free PMC article. Review.
In humans, genetic studies have shown that the reelin gene (RELN) is associated with a number of psychiatric diseases, including Schizophrenia (SZ), bipolar disorder (BP) and autistic spectrum disorder. ...Furthermore, we discuss the basis for selectin …
In humans, genetic studies have shown that the reelin gene (RELN) is associated with a number of psychiatric diseases, including Schi …
Treadmill exercise improves behavioral outcomes and spatial learning memory through up-regulation of reelin signaling pathway in autistic rats.
Seo TB, Cho HS, Shin MS, Kim CJ, Ji ES, Baek SS. Seo TB, et al. J Exerc Rehabil. 2013 Apr;9(2):220-9. doi: 10.12965/jer.130003. Epub 2013 Apr 25. J Exerc Rehabil. 2013. PMID: 24278864 Free PMC article.
Autism is a complex neurodevelopmental disability with impairments of social interaction and communication, and repetitive behavior. ...Neuroprotective effects of exercise on various brain insults are well documented, however, the effects of exercise on autism …
Autism is a complex neurodevelopmental disability with impairments of social interaction and communication, and repetitive beh …
Rare CACNA1H and RELN variants interact through mTORC1 pathway in oligogenic autism spectrum disorder.
Teles E Silva AL, Glaser T, Griesi-Oliveira K, Corrêa-Velloso J, Wang JYT, da Silva Campos G, Ulrich H, Balan A, Zarrei M, Higginbotham EJ, Scherer SW, Passos-Bueno MR, Sertié AL. Teles E Silva AL, et al. Transl Psychiatry. 2022 Jun 6;12(1):234. doi: 10.1038/s41398-022-01997-9. Transl Psychiatry. 2022. PMID: 35668055 Free PMC article.
Oligogenic inheritance of autism spectrum disorder (ASD) has been supported by several studies. ...Here, by using iPSC-derived neural progenitor cells (NPCs) and a heterologous expression system, we show that the variant in Cav3.2 leads to increased calcium influx i …
Oligogenic inheritance of autism spectrum disorder (ASD) has been supported by several studies. ...Here, by using iPSC-derived …
The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression.
Lammert DB, Middleton FA, Pan J, Olson EC, Howell BW. Lammert DB, et al. J Neurochem. 2017 Jul;142(1):89-102. doi: 10.1111/jnc.14045. Epub 2017 May 18. J Neurochem. 2017. PMID: 28419454 Free PMC article.
Despite the recent identification of over 40 missense heterozygous Reelin gene (RELN) mutations in autism spectrum disorder (ASD), none of these has been functionally characterized. ...This effect is recapitulated in a heterozygous RELN mouse mutant that is c …
Despite the recent identification of over 40 missense heterozygous Reelin gene (RELN) mutations in autism spectrum disorder …
Vldlr overexpression causes hyperactivity in rats.
Iwata K, Izumo N, Matsuzaki H, Manabe T, Ishibashi Y, Ichitani Y, Yamada K, Thanseem I, Anitha A, Vasu MM, Shimmura C, Wakuda T, Kameno Y, Takahashi T, Iwata Y, Suzuki K, Nakamura K, Mori N. Iwata K, et al. Mol Autism. 2012 Oct 30;3(1):11. doi: 10.1186/2040-2392-3-11. Mol Autism. 2012. PMID: 23110844 Free PMC article.
BACKGROUND: Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects and behavioral abnormalities. Several reports have i …
BACKGROUND: Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein …
Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders.
Sakai K, Shoji H, Kohno T, Miyakawa T, Hattori M. Sakai K, et al. Sci Rep. 2016 Jun 27;6:28636. doi: 10.1038/srep28636. Sci Rep. 2016. PMID: 27346785 Free PMC article.
The highly basic C-terminal region (CTR) of Reelin is necessary for efficient activation of its downstream signaling, and the brain structure of knock-in mice that lack the CTR (deltaC-KI mice) is impaired. ...These results suggest that CTR-dependent Reeli …
The highly basic C-terminal region (CTR) of Reelin is necessary for efficient activation of its downstream signaling, and the …
[Neurotransmission in developmental disorders].
Takeuchi Y. Takeuchi Y. No To Hattatsu. 2008 Nov;40(6):451-5. No To Hattatsu. 2008. PMID: 19039985 Review. Japanese.
Attention deficit/hyperactivity disorder (AD/HD) is a heterogeneous developmental disorder with an etiology that is not fully understood. ...There is accumulating neurobiological evidence pointing toward a role of the serotonin system in AD/HD. The etiology of au …
Attention deficit/hyperactivity disorder (AD/HD) is a heterogeneous developmental disorder with an etiology that is not fully …
Abnormal cell properties and down-regulated FAK-Src complex signaling in B lymphoblasts of autistic subjects.
Wei H, Malik M, Sheikh AM, Merz G, Ted Brown W, Li X. Wei H, et al. Am J Pathol. 2011 Jul;179(1):66-74. doi: 10.1016/j.ajpath.2011.03.034. Epub 2011 May 7. Am J Pathol. 2011. PMID: 21703394 Free PMC article.
The FAK-Src complex, activated by upstream reelin and integrin beta1, can initiate a cascade of phosphorylation events to trigger multiple intracellular pathways, including mitogen-activated protein kinase-extracellular signal-regulated kinase and phosphatidylinosit …
The FAK-Src complex, activated by upstream reelin and integrin beta1, can initiate a cascade of phosphorylation events to trigger mul …