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Results: 1 to 20 of 36

1.

Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways.

Basu D, Lettan R, Damodaran K, Strellec S, Reyes-Mugica M, Rebbaa A.

Mol Cancer Ther. 2014 Jun;13(6):1457-67. doi: 10.1158/1535-7163.MCT-13-0918. Epub 2014 Apr 2.

PMID:
24694946
[PubMed - in process]
2.

Histone acetylation-mediated regulation of the Hippo pathway.

Basu D, Reyes-Múgica M, Rebbaa A.

PLoS One. 2013 May 6;8(5):e62478. doi: 10.1371/journal.pone.0062478. Print 2013.

PMID:
23671600
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

OT-404, multi-targeted anti-cancer agent affecting tumor proliferation, chemo-resistance, and angiogenesis.

Rebbaa A, Patil G, Yalcin M, Sudha T, Mousa SA.

Cancer Lett. 2013 May 10;332(1):55-62. doi: 10.1016/j.canlet.2013.01.016. Epub 2013 Jan 21.

PMID:
23348692
[PubMed - indexed for MEDLINE]
4.

Role of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotype.

Basu D, Reyes-Mugica M, Rebbaa A.

PLoS One. 2012;7(12):e52188. doi: 10.1371/journal.pone.0052188. Epub 2012 Dec 18.

PMID:
23272224
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions.

Mousa SA, Gallati C, Simone T, Dier E, Yalcin M, Dyskin E, Thangirala S, Hanko C, Rebbaa A.

Aging (Albany NY). 2009 Mar 31;1(4):412-24.

PMID:
20195491
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The anti-angiogenic activity of NSITC, a specific cathepsin L inhibitor.

Rebbaa A, Chu F, Sudha T, Gallati C, Dier U, Dyskin E, Yalcin M, Bianchini C, Shaker O, Mousa SA.

Anticancer Res. 2009 Nov;29(11):4473-81.

PMID:
20032394
[PubMed - indexed for MEDLINE]
Free Article
7.

Stress resistant human embryonic stem cells as a potential source for the identification of novel cancer stem cell markers.

Mousa SA, Sudha T, Dyskin E, Dier U, Gallati C, Hanko C, Chittur SV, Rebbaa A.

Cancer Lett. 2010 Mar 28;289(2):208-16. doi: 10.1016/j.canlet.2009.08.018. Epub 2009 Sep 4.

PMID:
19733430
[PubMed - indexed for MEDLINE]
8.

Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism.

Zheng X, Chu F, Chou PM, Gallati C, Dier U, Mirkin BL, Mousa SA, Rebbaa A.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C65-74. doi: 10.1152/ajpcell.00082.2008. Epub 2008 Oct 29.

PMID:
18971393
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Role of the proteolytic hierarchy between cathepsin L, cathepsin D and caspase-3 in regulation of cellular susceptibility to apoptosis and autophagy.

Zheng X, Chu F, Mirkin BL, Sudha T, Mousa SA, Rebbaa A.

Biochim Biophys Acta. 2008 Dec;1783(12):2294-300. doi: 10.1016/j.bbamcr.2008.07.027. Epub 2008 Aug 13.

PMID:
18775751
[PubMed - indexed for MEDLINE]
Free Article
10.

Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway.

Chu F, Chou P, Mirkin BL, Mousa SA, Rebbaa A.

Aging Cell. 2008 Aug;7(4):516-25. doi: 10.1111/j.1474-9726.2008.00403.x. Epub 2008 Jul 8.

PMID:
18489729
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent.

Rebbaa A, Chu F, Davis FB, Davis PJ, Mousa SA.

Angiogenesis. 2008;11(3):269-76. doi: 10.1007/s10456-008-9110-8. Epub 2008 Apr 4.

PMID:
18386142
[PubMed - indexed for MEDLINE]
12.

Tetraiodothyroacetic acid, a small molecule integrin ligand, blocks angiogenesis induced by vascular endothelial growth factor and basic fibroblast growth factor.

Mousa SA, Bergh JJ, Dier E, Rebbaa A, O'Connor LJ, Yalcin M, Aljada A, Dyskin E, Davis FB, Lin HY, Davis PJ.

Angiogenesis. 2008;11(2):183-90. Epub 2007 Dec 13.

PMID:
18080776
[PubMed - indexed for MEDLINE]
13.

The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis.

Rebbaa A, Zheng X, Chu F, Mirkin BL.

Cell Death Differ. 2006 Nov;13(11):1960-7. Epub 2006 Mar 24.

PMID:
16557274
[PubMed - indexed for MEDLINE]
Free Article
14.

Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.

Chu F, Chou PM, Zheng X, Mirkin BL, Rebbaa A.

Cancer Res. 2005 Nov 15;65(22):10183-7.

PMID:
16288004
[PubMed - indexed for MEDLINE]
Free Article
15.

Identification of midkine as a mediator for intercellular transfer of drug resistance.

Mirkin BL, Clark S, Zheng X, Chu F, White BD, Greene M, Rebbaa A.

Oncogene. 2005 Jul 21;24(31):4965-74.

PMID:
15897897
[PubMed - indexed for MEDLINE]
16.

Targeting senescence pathways to reverse drug resistance in cancer.

Rebbaa A.

Cancer Lett. 2005 Feb 28;219(1):1-13. Review.

PMID:
15694659
[PubMed - indexed for MEDLINE]
17.

Modulation of Growth Factor response in brain tumors by complex carbohydrates.

Rebbaa A, Chou PM, Bremer EG.

Bull Cancer. 2004 Apr;91(4):E15-60. Review.

PMID:
15562557
[PubMed - indexed for MEDLINE]
18.

Senescence-initiated reversal of drug resistance: specific role of cathepsin L.

Zheng X, Chou PM, Mirkin BL, Rebbaa A.

Cancer Res. 2004 Mar 1;64(5):1773-80.

PMID:
14996739
[PubMed - indexed for MEDLINE]
Free Article
19.

Caspase inhibition switches doxorubicin-induced apoptosis to senescence.

Rebbaa A, Zheng X, Chou PM, Mirkin BL.

Oncogene. 2003 May 8;22(18):2805-11.

PMID:
12743603
[PubMed - indexed for MEDLINE]
20.

Doxorubicin resistant neuroblastoma cells secrete factors that activate AKT and attenuate cytotoxicity in drug-sensitive cells.

Emran MA, Rebbaa A, Mirkin BL.

Cancer Lett. 2002 Aug 8;182(1):53-9.

PMID:
12175523
[PubMed - indexed for MEDLINE]

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