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Results: 1 to 20 of 310

1.

C-Raf deficiency leads to hearing loss and increased noise susceptibility.

de Iriarte Rodríguez R, Magariños M, Pfeiffer V, Rapp UR, Varela-Nieto I.

Cell Mol Life Sci. 2015 May 15. [Epub ahead of print]

PMID:
25975225
2.

In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B.

Silva IT, Carvalho A, Lang KL, Dudek SE, Masemann D, Durán FJ, Caro MS, Rapp UR, Wixler V, Schenkel EP, Simões CM, Ludwig S.

PLoS One. 2015 Feb 12;10(2):e0117794. doi: 10.1371/journal.pone.0117794. eCollection 2015.

3.

Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.

Zanucco E, El-Nikhely N, Götz R, Weidmann K, Pfeiffer V, Savai R, Seeger W, Ullrich A, Rapp UR.

J Biol Chem. 2014 Sep 26;289(39):26804-16. doi: 10.1074/jbc.M114.558999. Epub 2014 Aug 5.

PMID:
25096573
4.

Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase.

Sibilski C, Mueller T, Kollipara L, Zahedi RP, Rapp UR, Rudel T, Baljuls A.

J Biol Chem. 2013 Dec 6;288(49):35237-52. doi: 10.1074/jbc.M113.490235. Epub 2013 Oct 24.

5.

Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum.

Pfeiffer V, Götz R, Xiang C, Camarero G, Braun A, Zhang Y, Blum R, Heinsen H, Nieswandt B, Rapp UR.

PLoS One. 2013;8(3):e58259. doi: 10.1371/journal.pone.0058259. Epub 2013 Mar 7.

6.

E-cadherin controls bronchiolar progenitor cells and onset of preneoplastic lesions in mice.

Ceteci F, Ceteci S, Zanucco E, Thakur C, Becker M, El-Nikhely N, Fink L, Seeger W, Savai R, Rapp UR.

Neoplasia. 2012 Dec;14(12):1164-77.

7.

MYC-induced epigenetic activation of GATA4 in lung adenocarcinoma.

Castro IC, Breiling A, Luetkenhaus K, Ceteci F, Hausmann S, Kress S, Lyko F, Rudel T, Rapp UR.

Mol Cancer Res. 2013 Feb;11(2):161-72. doi: 10.1158/1541-7786.MCR-12-0414-T. Epub 2012 Dec 13.

8.

MK3 controls Polycomb target gene expression via negative feedback on ERK.

Prickaerts P, Niessen HE, Mouchel-Vielh E, Dahlmans VE, van den Akker GG, Geijselaers C, Adriaens ME, Spaapen F, Takihara Y, Rapp UR, Peronnet F, Voncken JW.

Epigenetics Chromatin. 2012 Aug 7;5(1):12. doi: 10.1186/1756-8935-5-12.

9.

Role of melanoma inhibitor of apoptosis (ML-IAP) protein, a member of the baculoviral IAP repeat (BIR) domain family, in the regulation of C-RAF kinase and cell migration.

Oberoi-Khanuja TK, Karreman C, Larisch S, Rapp UR, Rajalingam K.

J Biol Chem. 2012 Aug 17;287(34):28445-55. doi: 10.1074/jbc.M112.341297. Epub 2012 Jun 18.

10.

The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.

Baljuls A, Beck M, Oenel A, Robubi A, Kroschewski R, Hekman M, Rudel T, Rapp UR.

J Biol Chem. 2012 Jun 29;287(27):23128-40. doi: 10.1074/jbc.M112.343780. Epub 2012 May 17.

11.

Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells.

Oak PS, Kopp F, Thakur C, Ellwart JW, Rapp UR, Ullrich A, Wagner E, Knyazev P, Roidl A.

Int J Cancer. 2012 Dec 15;131(12):2808-19. doi: 10.1002/ijc.27595. Epub 2012 May 21.

PMID:
22511343
12.

Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice.

Zanucco E, Götz R, Potapenko T, Carraretto I, Ceteci S, Ceteci F, Seeger W, Savai R, Rapp UR.

PLoS One. 2011;6(12):e29093. doi: 10.1371/journal.pone.0029093. Epub 2011 Dec 14.

14.

Specific antibody-receptor interactions trigger InlAB-independent uptake of Listeria monocytogenes into tumor cell lines.

Heisig M, Frentzen A, Bergmann B, Galmbacher K, Gentschev I, Hotz C, Schoen C, Stritzker J, Fensterle J, Rapp UR, Goebel W.

BMC Microbiol. 2011 Jul 11;11:163. doi: 10.1186/1471-2180-11-163.

15.

Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase.

Baljuls A, Mahr R, Schwarzenau I, Müller T, Polzien L, Hekman M, Rapp UR.

J Biol Chem. 2011 May 6;286(18):16491-503. doi: 10.1074/jbc.M110.194167. Epub 2011 Mar 18.

16.

BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling.

Polzien L, Baljuls A, Albrecht M, Hekman M, Rapp UR.

J Biol Chem. 2011 May 20;286(20):17934-44. doi: 10.1074/jbc.M110.177345. Epub 2011 Feb 11.

17.

Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages.

Sienerth AR, Scheuermann C, Galmiche A, Rapp UR, Becker M.

Immunol Cell Biol. 2011 Oct;89(7):812-6. doi: 10.1038/icb.2010.160. Epub 2011 Jan 11.

PMID:
21221124
18.

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development.

Magariños M, Aburto MR, Sánchez-Calderón H, Muñoz-Agudo C, Rapp UR, Varela-Nieto I.

PLoS One. 2010 Dec 28;5(12):e14435. doi: 10.1371/journal.pone.0014435.

19.

Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part.

Polzien L, Baljuls A, Roth HM, Kuper J, Benz R, Schweimer K, Hekman M, Rapp UR.

Biochim Biophys Acta. 2011 Feb;1810(2):162-9. doi: 10.1016/j.bbagen.2010.11.002. Epub 2010 Nov 24.

PMID:
21081150
20.

Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.

Molzan M, Schumacher B, Ottmann C, Baljuls A, Polzien L, Weyand M, Thiel P, Rose R, Rose M, Kuhenne P, Kaiser M, Rapp UR, Kuhlmann J, Ottmann C.

Mol Cell Biol. 2010 Oct;30(19):4698-711. doi: 10.1128/MCB.01636-09. Epub 2010 Aug 2.

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