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Items: 1 to 20 of 75

1.

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

Exner MP, Köhling S, Rivollier J, Gosling S, Srivastava P, Palyancheva ZI, Herdewijn P, Heck MP, Rademann J, Budisa N.

Molecules. 2016 Feb 29;21(3):287. doi: 10.3390/molecules21030287.

2.

Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10.

Köhling S, Künze G, Lemmnitzer K, Bermudez M, Wolber G, Schiller J, Huster D, Rademann J.

Chemistry. 2016 Apr 11;22(16):5563-74. doi: 10.1002/chem.201504459. Epub 2016 Feb 25.

PMID:
26918733
3.

Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

Mansour S, Tocheva AS, Cave-Ayland C, Machelett MM, Sander B, Lissin NM, Molloy PE, Baird MS, Stübs G, Schröder NW, Schumann RR, Rademann J, Postle AD, Jakobsen BK, Marshall BG, Gosain R, Elkington PT, Elliott T, Skylaris CK, Essex JW, Tews I, Gadola SD.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1266-75. doi: 10.1073/pnas.1519246113. Epub 2016 Feb 16.

4.

Identification of the Glycosaminoglycan Binding Site of Interleukin-10 by NMR Spectroscopy.

Künze G, Köhling S, Vogel A, Rademann J, Huster D.

J Biol Chem. 2016 Feb 5;291(6):3100-13. doi: 10.1074/jbc.M115.681759. Epub 2015 Dec 16.

PMID:
26677224
5.

Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor.

Urban N, Wang L, Kwiek S, Rademann J, Kuebler WM, Schaefer M.

Mol Pharmacol. 2016 Jan;89(1):197-213. doi: 10.1124/mol.115.100792. Epub 2015 Oct 23.

PMID:
26500253
6.

Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands.

Koschek K, Durmaz V, Krylova O, Wieczorek M, Gupta S, Richter M, Bujotzek A, Fischer C, Haag R, Freund C, Weber M, Rademann J.

Beilstein J Org Chem. 2015 May 18;11:837-47. doi: 10.3762/bjoc.11.93. eCollection 2015.

7.

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.

Wagner S, Schütz A, Rademann J.

Bioorg Med Chem. 2015 Jun 15;23(12):2839-47. doi: 10.1016/j.bmc.2015.03.074. Epub 2015 Apr 4.

PMID:
25907367
8.

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.

Grosskopf S, Eckert C, Arkona C, Radetzki S, Böhm K, Heinemann U, Wolber G, von Kries JP, Birchmeier W, Rademann J.

ChemMedChem. 2015 May;10(5):815-26. doi: 10.1002/cmdc.201500015. Epub 2015 Apr 15.

PMID:
25877780
9.

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

Lan L, Holland JD, Qi J, Grosskopf S, Rademann J, Vogel R, Györffy B, Wulf-Goldenberg A, Birchmeier W.

EMBO J. 2015 Jun 3;34(11):1493-508. doi: 10.15252/embj.201489004. Epub 2015 Mar 3. Erratum in: EMBO J. 2015 Sep 14;34(18):2383. EMBO J. 2015 Sep 14; 34(18):2383. Rademann, Jörg [added].

10.

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates.

Burda E, Rademann J.

Nat Commun. 2014 Nov 18;5:5170. doi: 10.1038/ncomms6170.

PMID:
25403979
11.

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.

El-Dahshan A, Al-Gharabli SI, Radetzki S, Al-Tel TH, Kumar P, Rademann J.

Bioorg Med Chem. 2014 Oct 1;22(19):5506-12. doi: 10.1016/j.bmc.2014.07.024. Epub 2014 Jul 24.

PMID:
25172146
12.

Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3.

Holland-Nell K, Fernández-Bachiller MI, Ahsanullah, Rademann J.

Org Lett. 2014 Sep 5;16(17):4428-31. doi: 10.1021/ol501910x. Epub 2014 Aug 20.

PMID:
25141292
13.

Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity.

Chakrabarti A, Witsenburg JJ, Sinzinger MD, Richter M, Wallbrecher R, Cluitmans JC, Verdurmen WP, Tanis S, Adjobo-Hermans MJ, Rademann J, Brock R.

Biochim Biophys Acta. 2014 Dec;1838(12):3097-106. doi: 10.1016/j.bbamem.2014.08.001. Epub 2014 Aug 7.

14.

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation.

Preidl JJ, Gnanapragassam VS, Lisurek M, Saupe J, Horstkorte R, Rademann J.

Angew Chem Int Ed Engl. 2014 May 26;53(22):5700-5. doi: 10.1002/anie.201400394. Epub 2014 Apr 15. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 28;53(31):7977.

PMID:
24737687
15.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

16.

Effects of charge and charge distribution on the cellular uptake of multivalent arginine-containing peptide-polymer conjugates.

Koschek K, Dathe M, Rademann J.

Chembiochem. 2013 Oct 11;14(15):1982-90. doi: 10.1002/cbic.201300365. Epub 2013 Sep 24.

PMID:
24115335
17.

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

Arkona C, Rademann J.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8210-2. doi: 10.1002/anie.201303544. Epub 2013 Jun 21. No abstract available.

PMID:
23794491
18.

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

Fernández-Bachiller MI, Horatscheck A, Lisurek M, Rademann J.

ChemMedChem. 2013 Jul;8(7):1041-56. doi: 10.1002/cmdc.201300078. Epub 2013 Jun 11.

PMID:
23757181
19.

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations.

Richter M, Chakrabarti A, Ruttekolk IR, Wiesner B, Beyermann M, Brock R, Rademann J.

Chemistry. 2012 Dec 21;18(52):16708-15. doi: 10.1002/chem.201202276. Epub 2012 Nov 4.

PMID:
23124530
20.

Fmoc-based synthesis of peptide thioacids for azide ligations via 2-cyanoethyl thioesters.

Raz R, Rademann J.

Org Lett. 2012 Oct 5;14(19):5038-41. doi: 10.1021/ol302247h. Epub 2012 Sep 19.

PMID:
22991969
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