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Results: 1 to 20 of 68

1.

Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic.

Wagner S, Schütz A, Rademann J.

Bioorg Med Chem. 2015 Apr 4. pii: S0968-0896(15)00270-9. doi: 10.1016/j.bmc.2015.03.074. [Epub ahead of print]

PMID:
25907367
2.

Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo.

Grosskopf S, Eckert C, Arkona C, Radetzki S, Böhm K, Heinemann U, Wolber G, von Kries JP, Birchmeier W, Rademann J.

ChemMedChem. 2015 May;10(5):815-26. doi: 10.1002/cmdc.201500015. Epub 2015 Apr 15.

PMID:
25877780
3.

Catalytic activation of pre-substrates via dynamic fragment assembly on protein templates.

Burda E, Rademann J.

Nat Commun. 2014 Nov 18;5:5170. doi: 10.1038/ncomms6170.

PMID:
25403979
4.

Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity.

El-Dahshan A, Al-Gharabli SI, Radetzki S, Al-Tel TH, Kumar P, Rademann J.

Bioorg Med Chem. 2014 Oct 1;22(19):5506-12. doi: 10.1016/j.bmc.2014.07.024. Epub 2014 Jul 24.

PMID:
25172146
5.

Chemoselective Wittig and Michael ligations of unprotected peptidyl phosphoranes in water furnish potent inhibitors of caspase-3.

Holland-Nell K, Fernández-Bachiller MI, Ahsanullah, Rademann J.

Org Lett. 2014 Sep 5;16(17):4428-31. doi: 10.1021/ol501910x. Epub 2014 Aug 20.

PMID:
25141292
6.

Multivalent presentation of the cell-penetrating peptide nona-arginine on a linear scaffold strongly increases its membrane-perturbing capacity.

Chakrabarti A, Witsenburg JJ, Sinzinger MD, Richter M, Wallbrecher R, Cluitmans JC, Verdurmen WP, Tanis S, Adjobo-Hermans MJ, Rademann J, Brock R.

Biochim Biophys Acta. 2014 Dec;1838(12):3097-106. doi: 10.1016/j.bbamem.2014.08.001. Epub 2014 Aug 7.

PMID:
25109936
7.

Fluorescent mimetics of CMP-Neu5Ac are highly potent, cell-permeable polarization probes of eukaryotic and bacterial sialyltransferases and inhibit cellular sialylation.

Preidl JJ, Gnanapragassam VS, Lisurek M, Saupe J, Horstkorte R, Rademann J.

Angew Chem Int Ed Engl. 2014 May 26;53(22):5700-5. doi: 10.1002/anie.201400394. Epub 2014 Apr 15. Erratum in: Angew Chem Int Ed Engl. 2014 Jul 28;53(31):7977.

PMID:
24737687
8.

Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.

Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. No abstract available.

9.

Effects of charge and charge distribution on the cellular uptake of multivalent arginine-containing peptide-polymer conjugates.

Koschek K, Dathe M, Rademann J.

Chembiochem. 2013 Oct 11;14(15):1982-90. doi: 10.1002/cbic.201300365. Epub 2013 Sep 24.

PMID:
24115335
10.

Propargyl amides as irreversible inhibitors of cysteine proteases--a lesson on the biological reactivity of alkynes.

Arkona C, Rademann J.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8210-2. doi: 10.1002/anie.201303544. Epub 2013 Jun 21. No abstract available.

PMID:
23794491
11.

Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

Fernández-Bachiller MI, Horatscheck A, Lisurek M, Rademann J.

ChemMedChem. 2013 Jul;8(7):1041-56. doi: 10.1002/cmdc.201300078. Epub 2013 Jun 11.

PMID:
23757181
12.

Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations.

Richter M, Chakrabarti A, Ruttekolk IR, Wiesner B, Beyermann M, Brock R, Rademann J.

Chemistry. 2012 Dec 21;18(52):16708-15. doi: 10.1002/chem.201202276. Epub 2012 Nov 4.

PMID:
23124530
13.

Fmoc-based synthesis of peptide thioacids for azide ligations via 2-cyanoethyl thioesters.

Raz R, Rademann J.

Org Lett. 2012 Oct 5;14(19):5038-41. doi: 10.1021/ol302247h. Epub 2012 Sep 19.

PMID:
22991969
14.

Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate.

Meyer BS, Rademann J.

J Biol Chem. 2012 Nov 2;287(45):37857-67. doi: 10.1074/jbc.M112.371500. Epub 2012 Aug 27.

15.

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56.

16.

Benzoylphosphonate-based photoactive phosphopeptide mimetics for modulation of protein tyrosine phosphatases and highly specific labeling of SH2 domains.

Horatscheck A, Wagner S, Ortwein J, Kim BG, Lisurek M, Beligny S, Schütz A, Rademann J.

Angew Chem Int Ed Engl. 2012 Sep 10;51(37):9441-7. doi: 10.1002/anie.201201475. Epub 2012 Aug 21. No abstract available.

PMID:
22907897
17.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

Fernández-Bachiller MI, Pérez C, Monjas L, Rademann J, Rodríguez-Franco MI.

J Med Chem. 2012 Feb 9;55(3):1303-17. doi: 10.1021/jm201460y. Epub 2012 Jan 27.

PMID:
22243648
18.

Soluble peptidyl phosphoranes for metal-free, stereoselective ligations in organic and aqueous solution.

Ahsanullah, Al-Gharabli SI, Rademann J.

Org Lett. 2012 Jan 6;14(1):14-7. doi: 10.1021/ol202627h. Epub 2011 Dec 2.

PMID:
22136619
19.

Dynamic substrate enhancement for the identification of specific, second-site-binding fragments targeting a set of protein tyrosine phosphatases.

Schmidt MF, Groves MR, Rademann J.

Chembiochem. 2011 Nov 25;12(17):2640-6. doi: 10.1002/cbic.201100414. Epub 2011 Nov 3.

PMID:
22052725
20.

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease.

Zhu L, George S, Schmidt MF, Al-Gharabli SI, Rademann J, Hilgenfeld R.

Antiviral Res. 2011 Nov;92(2):204-12. doi: 10.1016/j.antiviral.2011.08.001. Epub 2011 Aug 11.

PMID:
21854807
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