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Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.

Mäki-Nevala S, Sarhadi VK, Knuuttila A, Scheinin I, Ellonen P, Lagström S, Rönty M, Kettunen E, Husgafvel-Pursiainen K, Wolff H, Knuutila S.

Lung. 2015 Oct 13. [Epub ahead of print]


Elevated sputum BPIFB1 levels in smokers with chronic obstructive pulmonary disease: a longitudinal study.

Gao J, Ohlmeier S, Nieminen P, Toljamo T, Tiitinen S, Kanerva T, Bingle L, Araujo B, Rönty M, Höyhtyä M, Bingle CD, Mazur W, Pulkkinen V.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L17-26. doi: 10.1152/ajplung.00082.2015. Epub 2015 May 15.


Driver gene mutations of non-small-cell lung cancer are rare in primary carcinoids of the lung: NGS study by ion Torrent.

Armengol G, Sarhadi VK, Rönty M, Tikkanen M, Knuuttila A, Knuutila S.

Lung. 2015 Apr;193(2):303-8. doi: 10.1007/s00408-015-9690-1. Epub 2015 Feb 14.


Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.

Tamminen JA, Yin M, Rönty M, Sutinen E, Pasternack A, Ritvos O, Myllärniemi M, Koli K.

Exp Cell Res. 2015 Mar 1;332(1):102-15. doi: 10.1016/j.yexcr.2014.12.010. Epub 2014 Dec 31.


Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.

Myllärniemi M, Tikkanen J, Hulmi JJ, Pasternack A, Sutinen E, Rönty M, Leppäranta O, Ma H, Ritvos O, Koli K.

BMC Pulm Med. 2014 Nov 1;14:170. doi: 10.1186/1471-2466-14-170.


ALK fusion and its association with other driver gene mutations in Finnish non-small cell lung cancer patients.

Tuononen K, Kero M, Mäki-Nevala S, Sarhadi VK, Tikkanen M, Wirtanen T, Rönty M, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2014 Nov;53(11):895-901. doi: 10.1002/gcc.22198. Epub 2014 Jun 19.


Epidermal growth factor receptor mutations in 510 Finnish non--small-cell lung cancer patients.

Mäki-Nevala S, Rönty M, Morel M, Gomez M, Dawson Z, Sarhadi VK, Telaranta-Keerie A, Knuuttila A, Knuutila S.

J Thorac Oncol. 2014 Jun;9(6):886-91. doi: 10.1097/JTO.0000000000000132.


Comparative study of transforming growth factor-β signalling and regulatory molecules in human and canine idiopathic pulmonary fibrosis.

Lilja-Maula L, Syrjä P, Laurila HP, Sutinen E, Rönty M, Koli K, Rajamäki MM, Myllärniemi M.

J Comp Pathol. 2014 May;150(4):399-407. doi: 10.1016/j.jcpa.2013.12.001. Epub 2013 Dec 10.


Mutated ephrin receptor genes in non-small cell lung carcinoma and their occurrence with driver mutations-targeted resequencing study on formalin-fixed, paraffin-embedded tumor material of 81 patients.

Mäki-Nevala S, Kaur Sarhadi V, Tuononen K, Lagström S, Ellonen P, Rönty M, Wirtanen A, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2013 Dec;52(12):1141-9. doi: 10.1002/gcc.22109. Epub 2013 Oct 7.


Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug.

Tamminen JA, Parviainen V, Rönty M, Wohl AP, Murray L, Joenväärä S, Varjosalo M, Leppäranta O, Ritvos O, Sengle G, Renkonen R, Myllärniemi M, Koli K.

Oncogenesis. 2013 Aug 26;2:e66. doi: 10.1038/oncsis.2013.29.


Identification and validation of human papillomavirus encoded microRNAs.

Qian K, Pietilä T, Rönty M, Michon F, Frilander MJ, Ritari J, Tarkkanen J, Paulín L, Auvinen P, Auvinen E.

PLoS One. 2013 Jul 30;8(7):e70202. doi: 10.1371/journal.pone.0070202. Print 2013.


The histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man.

Syrjä P, Heikkilä HP, Lilja-Maula L, Krafft E, Clercx C, Day MJ, Rönty M, Myllärniemi M, Rajamäki MM.

J Comp Pathol. 2013 Aug-Oct;149(2-3):303-13. doi: 10.1016/j.jcpa.2013.03.006. Epub 2013 May 9.


Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methods.

Tuononen K, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Knuuttila A, Remes S, Telaranta-Keerie AI, Bloor S, Ellonen P, Knuutila S.

Biomed Res Int. 2013;2013:757490. doi: 10.1155/2013/757490. Epub 2013 Jan 20.


Comparison of targeted next-generation sequencing (NGS) and real-time PCR in the detection of EGFR, KRAS, and BRAF mutations on formalin-fixed, paraffin-embedded tumor material of non-small cell lung carcinoma-superiority of NGS.

Tuononen K, Mäki-Nevala S, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Andrews JM, Telaranta-Keerie AI, Hannula S, Lagström S, Ellonen P, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2013 May;52(5):503-11. doi: 10.1002/gcc.22047. Epub 2013 Jan 30.


Altered expression of ezrin, E-Cadherin and β-Catenin in cervical neoplasia.

Auvinen E, Carpen O, Korpela T, Ronty M, Vaheri A, Tarkkanen J.

Neoplasma. 2013;60(1):56-61. doi: 10.4149/neo_2013_008.


Distribution and levels of alpha-1-antitrypsin in the lung and plasma in smokers and chronic obstructive pulmonary disease.

Linja-aho A, Mazur W, Toljamo T, Nieminen P, Ohlmeier S, Rönty M, Kinnula VL.

APMIS. 2013 Jan;121(1):11-21. doi: 10.1111/j.1600-0463.2012.02936.x. Epub 2012 Jun 28.


Cell culture model predicts human disease: Altered expression of junction proteins and matrix metalloproteinases in cervical dysplasia.

Kivi N, Rönty M, Tarkkanen J, Auvinen P, Auvinen E.

BMC Clin Pathol. 2012 Aug 3;12:9. doi: 10.1186/1472-6890-12-9.


SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.

Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I.

J Clin Invest. 2012 Jun;122(6):2032-45. doi: 10.1172/JCI60132. Epub 2012 May 1.


Soft tissue sarcoma - a population-based, nationwide study with special emphasis on local control.

Sampo MM, Rönty M, Tarkkanen M, Tukiainen EJ, Böhling TO, Blomqvist CP.

Acta Oncol. 2012 Jul;51(6):706-12. doi: 10.3109/0284186X.2011.643821. Epub 2012 Jan 10.


Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma.

Caldas J, Gehlenborg N, Kettunen E, Faisal A, Rönty M, Nicholson AG, Knuutila S, Brazma A, Kaski S.

Bioinformatics. 2012 Jan 15;28(2):246-53. doi: 10.1093/bioinformatics/btr634. Epub 2011 Nov 20.

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