4-quinolones inhibit biotransformation of caffeine.
Harder S, Staib AH, Beer C, Papenburg A, Stille W, Shah PM.
Harder S, et al.
Eur J Clin Pharmacol. 1988;35(6):651-6. doi: 10.1007/BF00637602.
Eur J Clin Pharmacol. 1988.
PMID: 2853056
Clinical Trial.
The pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been investigated in 12 healthy males (age 20-40 years) alone and during co-administration of the 4-quinolones ofloxacin, norfloxacin, pipemidic acid, ciprofloxacin, and enox …
The pharmacokinetics of caffeine, including formation of its major metabolite paraxanthine in plasma, has been investigated in 12 healthy ma …