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  • Showing results for pulmonary thrombosis in the mouse following intravenous administration of quantum dot labeled mesenchymal cells. Your search for Pulmonary thrombosis in the mouse following intravenous administration of quantum dot-labelled mesenchymal cellss retrieved no results.
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Nanotoxicology. 2010 Mar;4(1):98-105. doi: 10.3109/17435390903470093.

Pulmonary thrombosis in the mouse following intravenous administration of quantum dot-labeled mesenchymal cells.

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  • 1Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Abstract

Quantum dots (QDs) are emerging as novel diagnostic agents. Yet, only a few studies have examined the possible deleterious effects of QD-labeled stem cells. We assessed the potential toxic effects of QD-labeled human embryonic palatal mesenchymal (QD-HEPM) cells in male NOD/SCID mice for six months, following the administration of a single intravenous injection. Control animals were administered with non-labeled HEPM cells. No treatment-related clinical signs, hematological, or biochemical parameters were found in the QD-HEPM animals in comparison to control animals. Histologically, multifocal organizing thrombi were noted in the pulmonary arteries of all QD-HEPM animals from the one-week study group and in one animal from the one-month group. Additionally, increased severity of perivascular inflammation was noted at the injection sites of QD-HEPM animals from the one-week group. This is the first study reporting histopathological evidence for pro-thrombotic adverse effects mediated by QD labeling.

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