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Results: 1 to 20 of 179

1.

Quantitative Insight into the Design of Compounds Recognized by the L-Type Amino Acid Transporter 1 (LAT1).

Ylikangas H, Malmioja K, Peura L, Gynther M, Nwachukwu EO, Leppänen J, Laine K, Rautio J, Lahtela-Kakkonen M, Huttunen KM, Poso A.

ChemMedChem. 2014 Sep 9. doi: 10.1002/cmdc.201402281. [Epub ahead of print]

PMID:
25205473
[PubMed - as supplied by publisher]
2.

Identification of structural features in chemicals associated with cancer drug response: a systematic data-driven analysis.

Khan SA, Virtanen S, Kallioniemi OP, Wennerberg K, Poso A, Kaski S.

Bioinformatics. 2014 Sep 1;30(17):i497-504. doi: 10.1093/bioinformatics/btu456.

PMID:
25161239
[PubMed - in process]
Free PMC Article
3.

Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL).

Savinainen JR, Kansanen E, Pantsar T, Navia-Paldanius D, Parkkari T, Lehtonen M, Laitinen T, Nevalainen T, Poso A, Levonen AL, Laitinen JT.

Mol Pharmacol. 2014 Nov;86(5):522-35. doi: 10.1124/mol.114.094284. Epub 2014 Aug 19.

PMID:
25140003
[PubMed - in process]
4.

Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization.

Ammad-ud-din M, Georgii E, Gönen M, Laitinen T, Kallioniemi O, Wennerberg K, Poso A, Kaski S.

J Chem Inf Model. 2014 Aug 25;54(8):2347-59. doi: 10.1021/ci500152b. Epub 2014 Aug 6.

PMID:
25046554
[PubMed - in process]
5.

Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection.

Asquith CR, Meli ML, Konstantinova LS, Laitinen T, Peräkylä M, Poso A, Rakitin OA, Allenspach K, Hofmann-Lehmann R, Hilton ST.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2640-4. doi: 10.1016/j.bmcl.2014.04.073. Epub 2014 Apr 26.

PMID:
24813732
[PubMed - in process]
6.

Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na.

Mäki-Jouppila JH, Laine LJ, Rehnberg J, Narvi E, Tiikkainen P, Hukasova E, Halonen P, Lindqvist A, Kallio L, Poso A, Kallio MJ.

Mol Cancer Ther. 2014 May;13(5):1054-66. doi: 10.1158/1535-7163.MCT-13-0685. Epub 2014 Apr 18.

PMID:
24748653
[PubMed - in process]
7.

Quantitative insights for the design of substrate-based SIRT1 inhibitors.

Kokkonen P, Mellini P, Nyrhilä O, Rahnasto-Rilla M, Suuronen T, Kiviranta P, Huhtiniemi T, Poso A, Jarho E, Lahtela-Kakkonen M.

Eur J Pharm Sci. 2014 Aug 1;59:12-9. doi: 10.1016/j.ejps.2014.04.003. Epub 2014 Apr 18.

PMID:
24747578
[PubMed - in process]
8.

Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency.

Laitinen T, Navia-Paldanius D, Rytilahti R, Marjamaa JJ, Kařízková J, Parkkari T, Pantsar T, Poso A, Laitinen JT, Savinainen JR.

Mol Pharmacol. 2014 Mar;85(3):510-9. doi: 10.1124/mol.113.090795. Epub 2013 Dec 24.

PMID:
24368842
[PubMed - indexed for MEDLINE]
9.

Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors.

Kaczor AA, Karczmarzyk Z, Fruziński A, Pihlaja K, Sinkkonen J, Wiinämaki K, Kronbach C, Unverferth K, Poso A, Matosiuk D.

Bioorg Med Chem. 2014 Jan 15;22(2):787-95. doi: 10.1016/j.bmc.2013.12.013. Epub 2013 Dec 12.

PMID:
24368028
[PubMed - in process]
10.

Physiological indicators of stress and meat and carcass characteristics in tail bitten slaughter pigs.

Valros A, Munsterhjelm C, Puolanne E, Ruusunen M, Heinonen M, Peltoniemi OA, Pösö AR.

Acta Vet Scand. 2013 Oct 30;55:75. doi: 10.1186/1751-0147-55-75.

PMID:
24172255
[PubMed - in process]
Free PMC Article
11.

Structure-based molecular modeling approaches to GPCR oligomerization.

Kaczor AA, Selent J, Poso A.

Methods Cell Biol. 2013;117:91-104. doi: 10.1016/B978-0-12-408143-7.00005-0.

PMID:
24143973
[PubMed - indexed for MEDLINE]
12.

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T.

J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22.

PMID:
24083878
[PubMed - indexed for MEDLINE]
13.

Identification of novel SIRT3 inhibitor scaffolds by virtual screening.

Salo HS, Laitinen T, Poso A, Jarho E, Lahtela-Kakkonen M.

Bioorg Med Chem Lett. 2013 May 15;23(10):2990-5. doi: 10.1016/j.bmcl.2013.03.033. Epub 2013 Mar 16.

PMID:
23562596
[PubMed - indexed for MEDLINE]
14.

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling.

Käsnänen H, Minkkilä A, Taupila S, Patel JZ, Parkkari T, Lahtela-Kakkonen M, Saario SM, Nevalainen T, Poso A.

Eur J Pharm Sci. 2013 Jun 14;49(3):423-33. doi: 10.1016/j.ejps.2013.03.015. Epub 2013 Apr 2.

PMID:
23557840
[PubMed - indexed for MEDLINE]
15.

Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase.

Aaltonen N, Savinainen JR, Ribas CR, Rönkkö J, Kuusisto A, Korhonen J, Navia-Paldanius D, Häyrinen J, Takabe P, Käsnänen H, Pantsar T, Laitinen T, Lehtonen M, Pasonen-Seppänen S, Poso A, Nevalainen T, Laitinen JT.

Chem Biol. 2013 Mar 21;20(3):379-90. doi: 10.1016/j.chembiol.2013.01.012.

PMID:
23521796
[PubMed - indexed for MEDLINE]
Free Article
16.

Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.

Kokkonen P, Rahnasto-Rilla M, Kiviranta PH, Huhtiniemi T, Laitinen T, Poso A, Jarho E, Lahtela-Kakkonen M.

ACS Med Chem Lett. 2012 Oct 23;3(12):969-74. doi: 10.1021/ml300139n. eCollection 2012 Dec 13.

PMID:
24900419
[PubMed]
Free PMC Article
17.

Structure-activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion.

Ylikangas H, Peura L, Malmioja K, Leppänen J, Laine K, Poso A, Lahtela-Kakkonen M, Rautio J.

Eur J Pharm Sci. 2013 Feb 14;48(3):523-31. doi: 10.1016/j.ejps.2012.11.014. Epub 2012 Dec 8.

PMID:
23228412
[PubMed - in process]
18.

Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.

Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A.

J Med Chem. 2012 Dec 27;55(24):10937-47. doi: 10.1021/jm3011614. Epub 2012 Dec 12.

PMID:
23189967
[PubMed - indexed for MEDLINE]
19.

Discovery of novel cannabinoid receptor ligands by a virtual screening approach: further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists.

Yrjölä S, Kalliokoski T, Laitinen T, Poso A, Parkkari T, Nevalainen T.

Eur J Pharm Sci. 2013 Jan 23;48(1-2):9-20. doi: 10.1016/j.ejps.2012.10.020. Epub 2012 Nov 3.

PMID:
23131798
[PubMed - indexed for MEDLINE]
20.

Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs.

Khan SA, Faisal A, Mpindi JP, Parkkinen JA, Kalliokoski T, Poso A, Kallioniemi OP, Wennerberg K, Kaski S.

BMC Bioinformatics. 2012 May 30;13:112. doi: 10.1186/1471-2105-13-112.

PMID:
22646858
[PubMed - indexed for MEDLINE]
Free PMC Article

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