Polycyclic compounds by Ugi-Pictet-Spengler sequence.
J Org Chem. 2011.
PMID: 21190371
Free PMC article.
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Polycyclic compounds by Ugi-Pictet-Spengler sequence.
Wang W, Ollio S, Herdtweck E, Dömling A.
Wang W, et al.
J Org Chem. 2011 Jan 21;76(2):637-44. doi: 10.1021/jo102058s. Epub 2010 Dec 29.
J Org Chem. 2011.
PMID: 21190371
Free PMC article.
A general approach to architecturally stimulating polycyclic structures is described by a concise, two-step procedure including a Ugi MCR (multicomponent reaction) and a subsequent Pictet-Spengler reaction starting from phenylethylamine-derived isocyanides. Ten compound …
A general approach to architecturally stimulating polycyclic structures is described by a concise, two-step procedure including a Ugi …
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Beyond Pseudo-natural Products: Sequential Ugi/Pictet-Spengler Reactions Leading to Steroidal Pyrazinoisoquinolines That Trigger Caspase-Independent Death in HepG2 Cells.
Alonso F, Galilea A, Mañez PA, Acebedo SL, Cabrera GM, Otero M, Barquero AA, Ramírez JA.
Alonso F, et al.
ChemMedChem. 2021 Jun 17;16(12):1945-1955. doi: 10.1002/cmdc.202100052. Epub 2021 Mar 31.
ChemMedChem. 2021.
PMID: 33682316
In this work, we describe how stereochemically complex polycyclic compounds can be generated by applying a synthetic sequence comprising an intramolecular Ugi reaction followed by a Pictet-Spengler cyclization on steroid-derived scaffolds. ...One of the new …
In this work, we describe how stereochemically complex polycyclic compounds can be generated by applying a synthetic sequen …
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