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1982 3
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104 results

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Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro.
Cejic SS, Kennedy TG. Cejic SS, et al. Prostaglandins. 1991 Aug;42(2):179-89. doi: 10.1016/0090-6980(91)90076-r. Prostaglandins. 1991. PMID: 1775638
Piriprost (100 microM) was found to decrease 5-hydroxyeicosatetraenoic acid (a 5-lipoxygenase product) by 53% after 72 hr which provided evidence that 5-lipoxygenase was being inhibited by piriprost. Lactate dehydrogenase (LDH) activity confirmed that piriprost …
Piriprost (100 microM) was found to decrease 5-hydroxyeicosatetraenoic acid (a 5-lipoxygenase product) by 53% after 72 hr which provi …
Effect of inhaled piriprost (U-60, 257) a novel leukotriene inhibitor, on allergen and exercise induced bronchoconstriction in asthma.
Mann JS, Robinson C, Sheridan AQ, Clement P, Bach MK, Holgate ST. Mann JS, et al. Thorax. 1986 Oct;41(10):746-52. doi: 10.1136/thx.41.10.746. Thorax. 1986. PMID: 3538476 Free PMC article. Clinical Trial.
In the four subjects with a documented late asthmatic reaction 2-12 hours after allergen challenge piriprost had no protective effect when compared with placebo. In the subjects who recorded PEF over 20 hours after allergen challenge there was no significant difference bet …
In the four subjects with a documented late asthmatic reaction 2-12 hours after allergen challenge piriprost had no protective effect …
Piriprost: a selective inhibitor of leukotriene synthesis.
Bach MK, Bowman BJ, Brashler JR, Fitzpatrick FA, Griffin RL, Johnson HG, Major NJ, McGuire JC, McNee ML, Richards IM, et al. Bach MK, et al. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:225-7. Adv Prostaglandin Thromboxane Leukot Res. 1985. PMID: 2936098 No abstract available.
Piriprost pretreatment attenuates the smoke-induced increase in 99mTcDTPA lung clearance.
Witten ML, Grad R, Quan SF, Sobonya RE, Hubbard AK, Lantz RC, Lentz LA, Devine LC, Lemen RJ. Witten ML, et al. Exp Lung Res. 1990 Jul-Aug;16(4):339-53. doi: 10.3109/01902149009108849. Exp Lung Res. 1990. PMID: 2118452
In addition, alveolar macrophage acid phosphatase enzyme activity increased in smoke-exposed rabbits. The leukotriene synthesis inhibitor, piriprost (U-60,257), given before smoke exposure, caused attenuation of the changes in 99mTcDTPA uptake and plasminogen activator, sw …
In addition, alveolar macrophage acid phosphatase enzyme activity increased in smoke-exposed rabbits. The leukotriene synthesis inhibitor, …
Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Tew KD, Bomber AM, Hoffman SJ. Tew KD, et al. Cancer Res. 1988 Jul 1;48(13):3622-5. Cancer Res. 1988. PMID: 3288331
Ethacrynic acid and piriprost (6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1) have been shown to potentiate the cytotoxic activity of chlorambucil in rat and human tumor cell lines. Walker 256 rat breast carcinoma cells (WS), with acquired resistance to nitrogen …
Ethacrynic acid and piriprost (6,9-deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin I1) have been shown to potentiate the cytotoxic …
Effects of piriprost (U-60, 257B) and leukotrienes on alkaline phosphatase activity of rat endometrial stromal cells in vitro.
Cejic SS, Kennedy TG. Cejic SS, et al. Prostaglandins. 1991 Aug;42(2):163-79. doi: 10.1016/0090-6980(91)90075-q. Prostaglandins. 1991. PMID: 1663640
The present study investigated the effects of piriprost (U-60,257B; an inhibitor of LT synthesis) and various LTs on alkaline phosphatase (ALP) activity of rat endometrial stromal cells in vitro. ...At 72 hr, as indicated by analyses of variance, there were significant int …
The present study investigated the effects of piriprost (U-60,257B; an inhibitor of LT synthesis) and various LTs on alkaline phospha …
Inhibition of the 5-lipoxygenase pathway with piriprost (U-60,257) protects normal primates from ozone-induced methacholine hyperresponsive small airways.
Johnson HG, Stout BK, Ruppel PL. Johnson HG, et al. Prostaglandins. 1988 Mar;35(3):459-66. doi: 10.1016/0090-6980(88)90136-0. Prostaglandins. 1988. PMID: 3287458
A second exposure led to similar response peaks in 6 weeks. At the peak of the second response, weekly 1% piriprost exposure before ozone led to a return to baseline that was not different between placebo and piriprost treated animals (9.4 +/- 1.0 and 4.3 +/- 2.9 we …
A second exposure led to similar response peaks in 6 weeks. At the peak of the second response, weekly 1% piriprost exposure before o …
Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs.
Lebidois J, Soifer SJ, Clyman RI, Heymann MA. Lebidois J, et al. Pediatr Res. 1987 Sep;22(3):350-4. doi: 10.1203/00006450-198709000-00022. Pediatr Res. 1987. PMID: 3309861
This hypothesis would be strengthened if inhibition of leukotriene synthesis also produced similar hemodynamic changes. We therefore studied the effects of piriprost (U 60257), a putative leukotriene synthesis inhibitor, on thirteen fetal lambs at 137 to 140 days gestation …
This hypothesis would be strengthened if inhibition of leukotriene synthesis also produced similar hemodynamic changes. We therefore studied …
Inhibition of rat liver glutathione S-transferases by piriprost: kinetics of the inhibition and preliminary evidence that piriprost may be a poor alternative substrate for these enzymes.
Bach MK, O'Brien J, Brashler JR, Johnson MA, Morton DR Jr. Bach MK, et al. Res Commun Chem Pathol Pharmacol. 1985 Sep;49(3):361-86. Res Commun Chem Pathol Pharmacol. 1985. PMID: 3903894
The administration of tritiated piriprost, an inhibitor of leukotriene formation, to rats resulted in its rapid excretion. ...The finding that piriprost is a potent inhibitor of several partially purified cytosolic liver glutathione S-transferases ( EC 2.5.1.18) is …
The administration of tritiated piriprost, an inhibitor of leukotriene formation, to rats resulted in its rapid excretion. ...The fin …
Effect of the 5-lipoxygenase inhibitor piriprost on superoxide production by human neutrophils.
Flament J, Schandene L, Boeynaems JM. Flament J, et al. Prostaglandins Leukot Essent Fatty Acids. 1988 Dec;34(3):175-80. doi: 10.1016/0952-3278(88)90142-1. Prostaglandins Leukot Essent Fatty Acids. 1988. PMID: 2851839
Piriprost inhibited the stimulatory effect of fMLP on superoxide anion (O2-) generation, at concentrations higher than those which depress leukotriene B4 (LTB4) formation. ...Neither exogenous LTB4 nor indomethacin were able to reverse the inhibitory effect of piriprost …
Piriprost inhibited the stimulatory effect of fMLP on superoxide anion (O2-) generation, at concentrations higher than those which de …
104 results