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Items: 19


Macrophages, Inflammation, and Lung Cancer.

Conway EM, Pikor LA, Kung SH, Hamilton MJ, Lam S, Lam WL, Bennewith KL.

Am J Respir Crit Care Med. 2016 Jan 15;193(2):116-30. doi: 10.1164/rccm.201508-1545CI.


Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology.

Martinez VD, Vucic EA, Thu KL, Hubaux R, Enfield KS, Pikor LA, Becker-Santos DD, Brown CJ, Lam S, Lam WL.

Sci Rep. 2015 May 27;5:10423. doi: 10.1038/srep10423.


Microtubule affinity-regulating kinase 2 is associated with DNA damage response and cisplatin resistance in non-small cell lung cancer.

Hubaux R, Thu KL, Vucic EA, Pikor LA, Kung SH, Martinez VD, Mosslemi M, Becker-Santos DD, Gazdar AF, Lam S, Lam WL.

Int J Cancer. 2015 Nov 1;137(9):2072-82. doi: 10.1002/ijc.29577. Epub 2015 May 6.


SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types.

Thu KL, Becker-Santos DD, Radulovich N, Pikor LA, Lam WL, Tsao MS.

Oncoscience. 2014 Jun 2;1(5):326-35. eCollection 2014.


Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology.

Vucic EA, Thu KL, Pikor LA, Enfield KS, Yee J, English JC, MacAulay CE, Lam S, Jurisica I, Lam WL.

BMC Cancer. 2014 Oct 24;14:778. doi: 10.1186/1471-2407-14-778.


Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.

Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.

Biomed Res Int. 2014;2014:159459. doi: 10.1155/2014/159459. Epub 2014 Jul 9.


Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer.

Martinez VD, Vucic EA, Thu KL, Pikor LA, Lam S, Lam WL.

Head Neck. 2015 May;37(5):727-34. doi: 10.1002/hed.23663. Epub 2014 Jun 18.


YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.

Pikor LA, Lockwood WW, Thu KL, Vucic EA, Chari R, Gazdar AF, Lam S, Lam WL.

Cancer Res. 2013 Dec 15;73(24):7301-12. doi: 10.1158/0008-5472.CAN-13-1897. Epub 2013 Oct 29.


Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.

Martinez VD, Vucic EA, Pikor LA, Thu KL, Hubaux R, Lam WL.

Mol Cancer. 2013 Oct 20;12(1):124. doi: 10.1186/1476-4598-12-124.


Genetic alterations defining NSCLC subtypes and their therapeutic implications.

Pikor LA, Ramnarine VR, Lam S, Lam WL.

Lung Cancer. 2013 Nov;82(2):179-89. doi: 10.1016/j.lungcan.2013.07.025. Epub 2013 Aug 20. Review.


SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling.

Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS.

Oncogene. 2014 Jan 16;33(3):279-88. doi: 10.1038/onc.2012.595. Epub 2013 Jan 14.


Mechanistic Roles of Noncoding RNAs in Lung Cancer Biology and Their Clinical Implications.

Enfield KS, Pikor LA, Martinez VD, Lam WL.

Genet Res Int. 2012;2012:737416. doi: 10.1155/2012/737416. Epub 2012 Jul 18.


Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.

Lockwood WW, Wilson IM, Coe BP, Chari R, Pikor LA, Thu KL, Solis LM, Nunez MI, Behrens C, Yee J, English J, Murray N, Tsao MS, Minna JD, Gazdar AF, Wistuba II, MacAulay CE, Lam S, Lam WL.

PLoS One. 2012;7(5):e37775. doi: 10.1371/journal.pone.0037775. Epub 2012 May 21.


Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma.

Lockwood WW, Thu KL, Lin L, Pikor LA, Chari R, Lam WL, Beer DG.

Clin Cancer Res. 2012 Apr 1;18(7):1936-46. doi: 10.1158/1078-0432.CCR-11-1431. Epub 2012 Feb 10.


Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF-kappaB pathway activation in lung cancer.

Thu KL, Pikor LA, Chari R, Wilson IM, Macaulay CE, English JC, Tsao MS, Gazdar AF, Lam S, Lam WL, Lockwood WW.

J Thorac Oncol. 2011 Sep;6(9):1521-9. doi: 10.1097/JTO.0b013e3182289479.


MicroRNA gene dosage alterations and drug response in lung cancer.

Enfield KS, Stewart GL, Pikor LA, Alvarez CE, Lam S, Lam WL, Chari R.

J Biomed Biotechnol. 2011;2011:474632. doi: 10.1155/2011/474632. Epub 2011 Mar 31.


DNA extraction from paraffin embedded material for genetic and epigenetic analyses.

Pikor LA, Enfield KS, Cameron H, Lam WL.

J Vis Exp. 2011 Mar 26;(49). pii: 2763. doi: 10.3791/2763.


A sequence-based approach to identify reference genes for gene expression analysis.

Chari R, Lonergan KM, Pikor LA, Coe BP, Zhu CQ, Chan TH, MacAulay CE, Tsao MS, Lam S, Ng RT, Lam WL.

BMC Med Genomics. 2010 Aug 3;3:32. doi: 10.1186/1755-8794-3-32.


Methylation analysis by DNA immunoprecipitation.

Thu KL, Pikor LA, Kennett JY, Alvarez CE, Lam WL.

J Cell Physiol. 2010 Mar;222(3):522-31. doi: 10.1002/jcp.22009. Review.

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