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The Next Generation of Risk Assessment Multiyear Study- Highlights of Findings, Applications to Risk Assessment and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Apr 19. [Epub ahead of print] Review.


Predicting chemical bioavailability using microarray gene expression data and regression modeling: A tale of three explosive compounds.

Gong P, Nan X, Barker ND, Boyd RE, Chen Y, Wilkins DE, Johnson DR, Suedel BC, Perkins EJ.

BMC Genomics. 2016 Mar 8;17(1):205. doi: 10.1186/s12864-016-2541-5.


Intratracheal atomized surfactant provides similar outcomes as bolus surfactant in preterm lambs with respiratory distress syndrome.

Milesi I, Tingay DG, Zannin E, Bianco F, Tagliabue P, Mosca F, Lavizzari A, Ventura ML, Zonneveld CE, Perkins EJ, Black D, Sourial M, Dellacá RL.

Pediatr Res. 2016 Mar 8. doi: 10.1038/pr.2016.39. [Epub ahead of print]


Peri-operative management of neonates with oesophageal atresia and tracheo-oesophageal fistula.

Hunt RW, Perkins EJ, King S.

Paediatr Respir Rev. 2016 Jan 29. pii: S1526-0542(16)00003-8. doi: 10.1016/j.prrv.2016.01.002. [Epub ahead of print] Review.


Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles.

Wang RL, Biales AD, Garcia-Reyero N, Perkins EJ, Villeneuve DL, Ankley GT, Bencic DC.

BMC Genomics. 2016 Jan 28;17(1):84. doi: 10.1186/s12864-016-2406-y.


Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics.

Watanabe KH, Mayo M, Jensen KM, Villeneuve DL, Ankley GT, Perkins EJ.

PLoS One. 2016 Jan 12;11(1):e0146594. doi: 10.1371/journal.pone.0146594. eCollection 2016.


A weight of evidence assessment approach for adverse outcome pathways.

Collier ZA, Gust KA, Gonzalez-Morales B, Gong P, Wilbanks MS, Linkov I, Perkins EJ.

Regul Toxicol Pharmacol. 2016 Mar;75:46-57. doi: 10.1016/j.yrtph.2015.12.014. Epub 2015 Dec 24.


Relating suborganismal processes to ecotoxicological and population level endpoints using a bioenergetic model.

Ananthasubramaniam B, McCauley E, Gust KA, Kennedy AJ, Muller EB, Perkins EJ, Nisbet RM.

Ecol Appl. 2015 Sep;25(6):1691-710.


Transcriptional Network Growing Models Using Motif-Based Preferential Attachment.

Abdelzaher AF, Al-Musawi AF, Ghosh P, Mayo ML, Perkins EJ.

Front Bioeng Biotechnol. 2015 Oct 12;3:157. doi: 10.3389/fbioe.2015.00157. eCollection 2015. Review.


Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers.

Gong P, Hong H, Perkins EJ.

Biomark Med. 2015;9(11):1225-39. doi: 10.2217/bmm.15.58. Epub 2015 Oct 28.


Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence.

Perkins EJ, Antczak P, Burgoon L, Falciani F, Garcia-Reyero N, Gutsell S, Hodges G, Kienzler A, Knapen D, McBride M, Willett C.

Toxicol Sci. 2015 Nov;148(1):14-25. doi: 10.1093/toxsci/kfv181.


Ecotoxicogenomics: Microarray interlaboratory comparability.

Vidal-Dorsch DE, Bay SM, Moore S, Layton B, Mehinto AC, Vulpe CD, Brown-Augustine M, Loguinov A, Poynton H, Garcia-Reyero N, Perkins EJ, Escalon L, Denslow ND, Cristina CD, Doan T, Shukradas S, Bruno J, Brown L, Van Agglen G, Jackman P, Bauer M.

Chemosphere. 2016 Feb;144:193-200. doi: 10.1016/j.chemosphere.2015.08.019. Epub 2015 Sep 10.


Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite.

Gust KA, Nanduri B, Rawat A, Wilbanks MS, Ang CY, Johnson DR, Pendarvis K, Chen X, Quinn MJ Jr, Johnson MS, Burgess SC, Perkins EJ.

BMC Genomics. 2015 Aug 7;16:587. doi: 10.1186/s12864-015-1798-4.


Spatiotemporal Aeration and Lung Injury Patterns Are Influenced by the First Inflation Strategy at Birth.

Tingay DG, Rajapaksa A, Zonneveld CE, Black D, Perkins EJ, Adler A, Grychtol B, Lavizzari A, Frerichs I, Zahra VA, Davis PG.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):263-72. doi: 10.1165/rcmb.2015-0127OC.


MicroRNA and messenger RNA profiling reveals new biomarkers and mechanisms for RDX induced neurotoxicity.

Deng Y, Ai J, Guan X, Wang Z, Yan B, Zhang D, Liu C, Wilbanks MS, Escalon BL, Meyers SA, Yang MQ, Perkins EJ.

BMC Genomics. 2014;15 Suppl 11:S1. doi: 10.1186/1471-2164-15-S11-S1. Epub 2014 Dec 16.


Systematic Omics Analysis Review (SOAR) tool to support risk assessment.

McConnell ER, Bell SM, Cote I, Wang RL, Perkins EJ, Garcia-Reyero N, Gong P, Burgoon LD.

PLoS One. 2014 Dec 22;9(12):e110379. doi: 10.1371/journal.pone.0110379. eCollection 2014.


Natural Variation in Fish Transcriptomes: Comparative Analysis of the Fathead Minnow (Pimephales promelas) and Zebrafish (Danio rerio).

Wang RL, Bencic DC, Garcia-Reyero N, Perkins EJ, Villeneuve DL, Ankley GT, Biales AD.

PLoS One. 2014 Dec 10;9(12):e114178. doi: 10.1371/journal.pone.0114178. eCollection 2014.


Top-level dynamics and the regulated gene response of feed-forward loop transcriptional motifs.

Mayo M, Abdelzaher A, Perkins EJ, Ghosh P.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Sep;90(3):032706. Epub 2014 Sep 10.


The addition of tramadol to the standard of i.v. acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo-controlled trial.

Olischar M, Palmer GM, Orsini F, Davidson AJ, Perkins EJ, Lee KJ, Everest NJ, Cranswick NE, Hunt RW.

Paediatr Anaesth. 2014 Nov;24(11):1149-57. doi: 10.1111/pan.12477. Epub 2014 Jul 14.

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