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Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation.

Davenport GC, Hittner JB, Otieno V, Karim Z, Mukundan H, Fenimore PW, Hengartner NW, McMahon BH, Kempaiah P, Ong'echa JM, Perkins DJ.

Mediators Inflamm. 2016;2016:4286576. doi: 10.1155/2016/4286576. Epub 2016 Jun 22.


Epigenetic Mechanisms Governing Innate Inflammatory Responses.

Perkins DJ, Patel MC, Blanco JC, Vogel SN.

J Interferon Cytokine Res. 2016 Jul;36(7):454-61. doi: 10.1089/jir.2016.0003.


Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensis live vaccine strain.

Richard K, Vogel SN, Perkins DJ.

Innate Immun. 2016 Jul;22(5):363-72. doi: 10.1177/1753425916650027. Epub 2016 May 26.


Hypothyroidism risk compared among nine common bipolar disorder therapies in a large US cohort.

Lambert CG, Mazurie AJ, Lauve NR, Hurwitz NG, Young SS, Obenchain RL, Hengartner NW, Perkins DJ, Tohen M, Kerner B.

Bipolar Disord. 2016 May;18(3):247-60. doi: 10.1111/bdi.12391.


The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.

Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JH.

Infect Immun. 2016 May 24;84(6):1796-805. doi: 10.1128/IAI.01526-15. Print 2016 Jun.


Inflammation: Species-specific TLR signalling - insight into human disease.

Perkins DJ, Vogel SN.

Nat Rev Rheumatol. 2016 Mar 23;12(4):198-200. doi: 10.1038/nrrheum.2016.36. No abstract available.


Natural infection of Plasmodium brasilianum in humans: Man and monkey share quartan malaria parasites in the Venezuelan Amazon.

Lalremruata A, Magris M, Vivas-Martínez S, Koehler M, Esen M, Kempaiah P, Jeyaraj S, Perkins DJ, Mordmüller B, Metzger WG.

EBioMedicine. 2015 Jul 29;2(9):1186-92. doi: 10.1016/j.ebiom.2015.07.033. eCollection 2015 Sep.


Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively.

Perkins DJ, Rajaiah R, Tennant SM, Ramachandran G, Higginson EE, Dyson TN, Vogel SN.

J Immunol. 2015 Sep 1;195(5):2461-71. doi: 10.4049/jimmunol.1500105. Epub 2015 Jul 22.


CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

Rajaiah R, Perkins DJ, Ireland DD, Vogel SN.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6. doi: 10.1073/pnas.1424980112. Epub 2015 Jun 23.


Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs).

Perkins DJ, Vogel SN.

Cytokine. 2015 Aug;74(2):171-4. doi: 10.1016/j.cyto.2015.03.001. Epub 2015 Mar 25. Review.


Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages.

Ramachandran G, Perkins DJ, Schmidlein PJ, Tulapurkar ME, Tennant SM.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3394. doi: 10.1371/journal.pntd.0003394. eCollection 2015 Jan.


Predictions of x-ray scattering spectra for warm dense matter.

Souza AN, Perkins DJ, Starrett CE, Saumon D, Hansen SB.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Feb;89(2):023108. Epub 2014 Feb 24.


The Effects of Plasmodium vivax Gestational Malaria on the Clinical and Immune Status of Pregnant Women in Northwestern Colombia.

Yasnot MF, Perkins DJ, Corredor M, Yanow S, Carmona-Fonseca J, Maestre A.

Colomb Med (Cali). 2013 Sep 30;44(3):172-7. eCollection 2013 Jul.


Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study.

Ogutu BR, Onyango KO, Koskei N, Omondi EK, Ongecha JM, Otieno GA, Obonyo C, Otieno L, Eyase F, Johnson JD, Omollo R, Perkins DJ, Akhwale W, Juma E.

Malar J. 2014 Jan 28;13:33. doi: 10.1186/1475-2875-13-33.


Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.

Perkins DJ, Polumuri SK, Pennini ME, Lai W, Xie P, Vogel SN.

PLoS Pathog. 2013;9(7):e1003479. doi: 10.1371/journal.ppat.1003479. Epub 2013 Jul 11.


Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.

Anyona SB, Kempaiah P, Davenport GC, Vulule JM, Hittner JB, Ong'echa JM, Perkins DJ.

Biochem Biophys Res Commun. 2013 Jul 12;436(4):585-90. doi: 10.1016/j.bbrc.2013.05.089. Epub 2013 Jun 3.


Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.

Rajaiah R, Perkins DJ, Polumuri SK, Zhao A, Keegan AD, Vogel SN.

J Immunol. 2013 May 1;190(9):4763-72. doi: 10.4049/jimmunol.1202407. Epub 2013 Mar 29.


Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels.

Okeyo WA, Munde EO, Okumu W, Raballah E, Anyona SB, Vulule JM, Ong'echa JM, Perkins DJ, Ouma C.

BMC Immunol. 2013 Mar 25;14:15. doi: 10.1186/1471-2172-14-15.


Feedback-based, system-level properties of vertebrate-microbial interactions.

Rivas AL, Jankowski MD, Piccinini R, Leitner G, Schwarz D, Anderson KL, Fair JM, Hoogesteijn AL, Wolter W, Chaffer M, Blum S, Were T, Konah SN, Kempaiah P, Ong'echa JM, Diesterbeck US, Pilla R, Czerny CP, Hittner JB, Hyman JM, Perkins DJ.

PLoS One. 2013;8(2):e53984. doi: 10.1371/journal.pone.0053984. Epub 2013 Feb 20.


Cystic fibrosis CFBE41o- cells contain TLR1 SNP I602S and fail to respond to Mycobacterium abscessus.

Kempaiah P, Davidson LB, Perkins DJ, Byrd TF.

J Cyst Fibros. 2013 Dec;12(6):773-9. doi: 10.1016/j.jcf.2013.01.001. Epub 2013 Feb 9.

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