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Frailty, Inflammation and Immunosenescence.

Fulop T, McElhaney J, Pawelec G, Cohen AA, Morais JA, Dupuis G, Baehl S, Camous X, Witkowski JM, Larbi A.

Interdiscip Top Gerontol Geriatr. 2015;41:26-40. doi: 10.1159/000381134. Epub 2015 Jul 17.


Immune checkpoint targeting as anti-cancer immunotherapy: promises, questions, challenges and the need for predictive biomarkers at ASCO 2015.

Pandha H, Pawelec G.

Cancer Immunol Immunother. 2015 Sep;64(9):1071-4. doi: 10.1007/s00262-015-1748-7. Epub 2015 Aug 13.


The prognostic impact of specific CD4 T-cell responses is critically dependent on the target antigen in melanoma.

Zelba H, Weide B, Martens A, Bailur JK, Garbe C, Pawelec G.

Oncoimmunology. 2015 Jan 30;4(1):e955683. eCollection 2015 Jan.


No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort.

Goldeck D, Pawelec G, Norman K, Steinhagen-Thiessen E, Oettinger L, Haehnel K, Demuth I.

Biogerontology. 2015 Apr 24. [Epub ahead of print]


CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival.

Derhovanessian E, Chen S, Maier AB, Hähnel K, de Craen AJ, Roelofs H, Westendorp R, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):917-23. doi: 10.1093/gerona/glu128. Epub 2015 Apr 7.


Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

Vinay DS, Ryan EP, Pawelec G, Talib WH, Stagg J, Elkord E, Lichtor T, Decker WK, Whelan RL, Kumara HM, Signori E, Honoki K, Georgakilas AG, Amin A, Helferich WG, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Choi BK, Kwon BS.

Semin Cancer Biol. 2015 Mar 25. pii: S1044-579X(15)00019-X. doi: 10.1016/j.semcancer.2015.03.004. [Epub ahead of print] Review.


Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study.

Di Benedetto S, Derhovanessian E, Steinhagen-Thiessen E, Goldeck D, Müller L, Pawelec G.

Biogerontology. 2015 Oct;16(5):631-43. doi: 10.1007/s10522-015-9563-2. Epub 2015 Mar 3.


NK Cells are Activated in Amnestic Mild Cognitive Impairment but not in Mild Alzheimer's Disease Patients.

Le Page A, Bourgade K, Lamoureux J, Frost E, Pawelec G, Larbi A, Witkowski JM, Dupuis G, Fülöp T.

J Alzheimers Dis. 2015 Feb 26. [Epub ahead of print]


As we age: Does slippage of quality control in the immune system lead to collateral damage?

Müller L, Pawelec G.

Ageing Res Rev. 2015 Sep;23(Pt A):116-23. doi: 10.1016/j.arr.2015.01.005. Epub 2015 Feb 9. Review.


SENIEUR status of the originating cell donor negates certain 'anti-immunosenescence' effects of ebselen and N-acetyl cysteine in human T cell clone cultures.

Marthandan S, Freeburn R, Steinbrecht S, Pawelec G, Barnett Y.

Immun Ageing. 2014 Nov 30;11(1):17. doi: 10.1186/s12979-014-0017-5. eCollection 2014.


Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly.

Derhovanessian E, Maier AB, Hähnel K, McElhaney JE, Slagboom EP, Pawelec G.

J Immunol. 2014 Oct 1;193(7):3624-31. doi: 10.4049/jimmunol.1303361. Epub 2014 Sep 3.


Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma.

Zelba H, Weide B, Martens A, Derhovanessian E, Bailur JK, Kyzirakos C, Pflugfelder A, Eigentler TK, Di Giacomo AM, Maio M, Aarntzen EH, de Vries J, Sucker A, Schadendorf D, Büttner P, Garbe C, Pawelec G.

Clin Cancer Res. 2014 Aug 15;20(16):4390-9. doi: 10.1158/1078-0432.CCR-14-1015. Epub 2014 Jun 17.


Intralesional treatment of stage III metastatic melanoma patients with L19-IL2 results in sustained clinical and systemic immunologic responses.

Weide B, Eigentler TK, Pflugfelder A, Zelba H, Martens A, Pawelec G, Giovannoni L, Ruffini PA, Elia G, Neri D, Gutzmer R, Becker JC, Garbe C.

Cancer Immunol Res. 2014 Jul;2(7):668-78. doi: 10.1158/2326-6066.CIR-13-0206. Epub 2014 Apr 4.


On the immunological theory of aging.

Fulop T, Witkowski JM, Pawelec G, Alan C, Larbi A.

Interdiscip Top Gerontol. 2014;39:163-76. doi: 10.1159/000358904. Epub 2014 May 13. Review.


T-cell immunity in the aging human.

Pawelec G.

Haematologica. 2014 May;99(5):795-7. doi: 10.3324/haematol.2013.094383. No abstract available.


Inflammation, ageing and chronic disease.

Pawelec G, Goldeck D, Derhovanessian E.

Curr Opin Immunol. 2014 Aug;29:23-8. doi: 10.1016/j.coi.2014.03.007. Epub 2014 Apr 22. Review.


OMIP-020: phenotypic characterization of human γδ T-cells by multicolor flow cytometry.

Wistuba-Hamprecht K, Pawelec G, Derhovanessian E.

Cytometry A. 2014 Jun;85(6):522-4. doi: 10.1002/cyto.a.22470. Epub 2014 Apr 22. No abstract available.


New advances in CMV and immunosenescence.

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J.

Exp Gerontol. 2014 Jul;55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.

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