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Results: 1 to 20 of 370


Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.

Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY, Partridge L.

Brain. 2015 May 22. pii: awv132. [Epub ahead of print]


Longevity GWAS Using the Drosophila Genetic Reference Panel.

Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM.

J Gerontol A Biol Sci Med Sci. 2015 Apr 28. pii: glv047. [Epub ahead of print]


43 is neurotoxic and primes aggregation of Aβ40 in vivo.

Burnouf S, Gorsky MK, Dols J, Grönke S, Partridge L.

Acta Neuropathol. 2015 Apr 11. [Epub ahead of print]


Promoting health and longevity through diet: from model organisms to humans.

Fontana L, Partridge L.

Cell. 2015 Mar 26;161(1):106-18. doi: 10.1016/j.cell.2015.02.020. Review.


Celebrating 350 years of Philosophical Transactions: life sciences papers.

Partridge L.

Philos Trans R Soc Lond B Biol Sci. 2015 Apr 19;370(1666). pii: 20140380. doi: 10.1098/rstb.2014.0380. No abstract available.


Myc mouse and anti-ageing therapy.

Alic N, Partridge L.

Trends Endocrinol Metab. 2015 Apr;26(4):163-4. doi: 10.1016/j.tem.2015.02.005. Epub 2015 Feb 26.


Distinct regions of the large extracellular domain of tetraspanin CD9 are involved in the control of human multinucleated giant cell formation.

Hulme RS, Higginbottom A, Palmer J, Partridge LJ, Monk PN.

PLoS One. 2014 Dec 31;9(12):e116289. doi: 10.1371/journal.pone.0116289. eCollection 2014.


Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.

Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG.

Nucleic Acids Res. 2014 Dec 16;42(22):13920-38. doi: 10.1093/nar/gku1132. Epub 2014 Nov 26.


Using doubly-labeled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster.

Piper MD, Selman C, Speakman JR, Partridge L.

J Genet Genomics. 2014 Sep 20;41(9):505-12. doi: 10.1016/j.jgg.2014.07.004. Epub 2014 Aug 10.


Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster.

Alic N, Giannakou ME, Papatheodorou I, Hoddinott MP, Andrews TD, Bolukbasi E, Partridge L.

PLoS Genet. 2014 Sep 18;10(9):e1004619. doi: 10.1371/journal.pgen.1004619. eCollection 2014 Sep.


Intervening in ageing to prevent the diseases of ageing.

Partridge L.

Trends Endocrinol Metab. 2014 Nov;25(11):555-7. doi: 10.1016/j.tem.2014.08.003. Epub 2014 Aug 29.


Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease.

Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Tain LS, Bjedov I, Rogers I, Li L, Martinez P, Khericha M, Cabecinha M, Bähler J, Partridge L.

Front Aging Neurosci. 2014 Jul 30;6:190. doi: 10.3389/fnagi.2014.00190. eCollection 2014.


C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IO, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EM, Partridge L, Isaacs AM.

Science. 2014 Sep 5;345(6201):1192-4. doi: 10.1126/science.1256800. Epub 2014 Aug 7.


Guidance on clinical research involving infants, children and young people: an update for researchers and research ethics committees.

Modi N, Vohra J, Preston J, Elliott C, Van't Hoff W, Coad J, Gibson F, Partridge L, Brierley J, Larcher V, Greenough A; Working Party of the Royal College of Paediatrics and Child Health.

Arch Dis Child. 2014 Oct;99(10):887-91. doi: 10.1136/archdischild-2014-306444. Epub 2014 Jun 9. No abstract available.


The Effectiveness of Psychosocial Intervention for Individuals With Cleft Lip and/or Palate.

Norman A, Persson M, Stock N, Rumsey N, Sandy J, Waylen A, Edwards Z, Hammond V, Partridge L, Ness A.

Cleft Palate Craniofac J. 2015 May;52(3):301-10. doi: 10.1597/13-276. Epub 2014 May 30.


Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila.

Metaxakis A, Tain LS, Grönke S, Hendrich O, Hinze Y, Birras U, Partridge L.

PLoS Biol. 2014 Apr 1;12(4):e1001824. doi: 10.1371/journal.pbio.1001824. eCollection 2014 Apr.


Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin.

Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC.

Nat Immunol. 2014 May;15(5):423-30. doi: 10.1038/ni.2865. Epub 2014 Mar 30.


Cell-nonautonomous effects of dFOXO/DAF-16 in aging.

Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L.

Cell Rep. 2014 Feb 27;6(4):608-16. doi: 10.1016/j.celrep.2014.01.015. Epub 2014 Feb 6.


Editorial 2014.

Partridge L.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130496. doi: 10.1098/rstb.2013.0496. Print 2014 Jan 5. No abstract available.


A holidic medium for Drosophila melanogaster.

Piper MD, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L.

Nat Methods. 2014 Jan;11(1):100-5. doi: 10.1038/nmeth.2731. Epub 2013 Nov 17. Erratum in: Nat Methods. 2014 Sep;11(9):971.

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