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Results: 1 to 20 of 31


The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines.

Hicks DA, Makova NZ, Gough M, Parkin ET, Nalivaeva NN, Turner AJ.

J Biol Chem. 2013 Sep 6;288(36):26039-51. doi: 10.1074/jbc.M113.461269. Epub 2013 Jul 29.


Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signaling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells.

Parr-Sturgess CA, Tinker CL, Hart CA, Brown MD, Clarke NW, Parkin ET.

Mol Cancer Res. 2012 Oct;10(10):1282-93. doi: 10.1158/1541-7786.MCR-12-0312. Epub 2012 Aug 30.


Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event.

Parr-Sturgess CA, Rushton DJ, Parkin ET.

Biochem J. 2010 Dec 1;432(2):283-94. doi: 10.1042/BJ20100321.


Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.

Taylor DR, Parkin ET, Cocklin SL, Ault JR, Ashcroft AE, Turner AJ, Hooper NM.

J Biol Chem. 2009 Aug 21;284(34):22590-600. doi: 10.1074/jbc.M109.032599. Epub 2009 Jun 29.


Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.

Wilkinson DK, Turner EJ, Parkin ET, Garner AE, Harrison PJ, Crawford M, Stewart GW, Hooper NM.

Biochim Biophys Acta. 2008 Jan;1778(1):125-32. Epub 2007 Sep 29.


Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. Epub 2007 Jun 15.


Angiotensin-converting enzyme as a GPIase: a critical reevaluation.

Leisle L, Parkin ET, Turner AJ, Hooper NM.

Nat Med. 2005 Nov;11(11):1139-40. No abstract available.


Herpes simplex virus interferes with amyloid precursor protein processing.

Shipley SJ, Parkin ET, Itzhaki RF, Dobson CB.

BMC Microbiol. 2005 Aug 18;5:48.


Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

Lambert DW, Yarski M, Warner FJ, Thornhill P, Parkin ET, Smith AI, Hooper NM, Turner AJ.

J Biol Chem. 2005 Aug 26;280(34):30113-9. Epub 2005 Jun 27.


Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.

Parkin ET, Turner AJ, Hooper NM.

Protein Pept Lett. 2004 Oct;11(5):423-32. Review.


The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.

Allinson TM, Parkin ET, Condon TP, Schwager SL, Sturrock ED, Turner AJ, Hooper NM.

Eur J Biochem. 2004 Jun;271(12):2539-47.


Dual mechanisms for shedding of the cellular prion protein.

Parkin ET, Watt NT, Turner AJ, Hooper NM.

J Biol Chem. 2004 Mar 19;279(12):11170-8. Epub 2004 Jan 7.


ADAMs family members as amyloid precursor protein alpha-secretases.

Allinson TM, Parkin ET, Turner AJ, Hooper NM.

J Neurosci Res. 2003 Nov 1;74(3):342-52. Review.


The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.

Parkin ET, Tan F, Skidgel RA, Turner AJ, Hooper NM.

J Cell Sci. 2003 Aug 1;116(Pt 15):3079-87. Epub 2003 Jun 10.


A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.

Alfalah M, Parkin ET, Jacob R, Sturrock ED, Mentele R, Turner AJ, Hooper NM, Naim HY.

J Biol Chem. 2001 Jun 15;276(24):21105-9. Epub 2001 Mar 23.


The role of proteolysis in Alzheimer's disease.

Hooper NM, Trew AJ, Parkin ET, Turner AJ.

Adv Exp Med Biol. 2000;477:379-90. Review.

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