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Results: 20

1.

In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline.

Macone AB, Caruso BK, Leahy RG, Donatelli J, Weir S, Draper MP, Tanaka SK, Levy SB.

Antimicrob Agents Chemother. 2014;58(2):1127-35. doi: 10.1128/AAC.01242-13. Epub 2013 Dec 2.

2.

Mechanism of action of the novel aminomethylcycline antibiotic omadacycline.

Draper MP, Weir S, Macone A, Donatelli J, Trieber CA, Tanaka SK, Levy SB.

Antimicrob Agents Chemother. 2014;58(3):1279-83. doi: 10.1128/AAC.01066-13. Epub 2013 Sep 16.

3.

In vitro and in vivo antimalarial efficacies of optimized tetracyclines.

Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K, Rosenthal PJ, Nelson ML.

Antimicrob Agents Chemother. 2013 Jul;57(7):3131-6. doi: 10.1128/AAC.00451-13. Epub 2013 Apr 29.

4.

A randomized, evaluator-blind, phase 2 study comparing the safety and efficacy of omadacycline to those of linezolid for treatment of complicated skin and skin structure infections.

Noel GJ, Draper MP, Hait H, Tanaka SK, Arbeit RD.

Antimicrob Agents Chemother. 2012 Nov;56(11):5650-4. doi: 10.1128/AAC.00948-12. Epub 2012 Aug 20.

5.

The history of the tetracyclines.

Nelson ML, Levy SB.

Ann N Y Acad Sci. 2011 Dec;1241:17-32. doi: 10.1111/j.1749-6632.2011.06354.x. Review.

PMID:
22191524
6.

Anti-inflammatory activity of tetracyclines: applications to human disease.

Higgins PJ, Draper M, Nelson M.

Antiinflamm Antiallergy Agents Med Chem. 2011;10(2):132-52.

PMID:
25182060
7.

Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model.

Garrity-Ryan LK, Kim OK, Balada-Llasat JM, Bartlett VJ, Verma AK, Fisher ML, Castillo C, Songsungthong W, Tanaka SK, Levy SB, Mecsas J, Alekshun MN.

Infect Immun. 2010 Nov;78(11):4683-90. doi: 10.1128/IAI.01305-09. Epub 2010 Sep 7.

8.

Brief communication: Mass spectroscopic characterization of tetracycline in the skeletal remains of an ancient population from Sudanese Nubia 350-550 CE.

Nelson ML, Dinardo A, Hochberg J, Armelagos GJ.

Am J Phys Anthropol. 2010 Sep;143(1):151-4. doi: 10.1002/ajpa.21340.

PMID:
20564518
9.

N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability.

Grier MC, Garrity-Ryan LK, Bartlett VJ, Klausner KA, Donovan PJ, Dudley C, Alekshun MN, Tanaka SK, Draper MP, Levy SB, Kim OK.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3380-3. doi: 10.1016/j.bmcl.2010.04.014. Epub 2010 Apr 11.

PMID:
20434913
10.

N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents.

Kim OK, Garrity-Ryan LK, Bartlett VJ, Grier MC, Verma AK, Medjanis G, Donatelli JE, Macone AB, Tanaka SK, Levy SB, Alekshun MN.

J Med Chem. 2009 Sep 24;52(18):5626-34. doi: 10.1021/jm9006577.

11.

Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors.

Bowser TE, Bartlett VJ, Grier MC, Verma AK, Warchol T, Levy SB, Alekshun MN.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5652-5. Epub 2007 Aug 21.

PMID:
17766109
12.

MarA, SoxS and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritis.

Casaz P, Garrity-Ryan LK, McKenney D, Jackson C, Levy SB, Tanaka SK, Alekshun MN.

Microbiology. 2006 Dec;152(Pt 12):3643-50.

PMID:
17159217
13.

Commensals upon us.

Alekshun MN, Levy SB.

Biochem Pharmacol. 2006 Mar 30;71(7):893-900. Epub 2006 Feb 7. Review.

PMID:
16464437
14.

New advances in antibiotic development and discovery.

Alekshun MN.

Expert Opin Investig Drugs. 2005 Feb;14(2):117-34. Review.

PMID:
15757391
16.

Versatile and facile synthesis of diverse semisynthetic tetracycline derivatives via Pd-catalyzed reactions.

Nelson ML, Ismail MY, McIntyre L, Bhatia B, Viski P, Hawkins P, Rennie G, Andorsky D, Messersmith D, Stapleton K, Dumornay J, Sheahan P, Verma AK, Warchol T, Levy SB.

J Org Chem. 2003 Jul 25;68(15):5838-51. Erratum in: J Org Chem. 2003 Dec 26;68(26):10199.

PMID:
12868916
17.

Efficient cloning of full-length cDNAs based on cDNA size fractionation.

Draper MP, August PR, Connolly T, Packard B, Call KM.

Genomics. 2002 Apr;79(4):603-7.

PMID:
11944994
18.
19.

T-3811. Toyama/Bristol-Myers Squibb.

Frechette R.

Curr Opin Investig Drugs. 2001 Dec;2(12):1706-11. Review.

PMID:
11892932
20.

Computational methods to estimate drug development parameters.

Podlogar BL, Muegge I, Brice LJ.

Curr Opin Drug Discov Devel. 2001 Jan;4(1):102-9. Review.

PMID:
11727315
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