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Items: 12


Linking gene expression to phenotypes via pathway information.

Papatheodorou I, Oellrich A, Smedley D.

J Biomed Semantics. 2015 Apr 11;6:17. doi: 10.1186/s13326-015-0013-5. eCollection 2015.


Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster.

Alic N, Giannakou ME, Papatheodorou I, Hoddinott MP, Andrews TD, Bolukbasi E, Partridge L.

PLoS Genet. 2014 Sep 18;10(9):e1004619. doi: 10.1371/journal.pgen.1004619. eCollection 2014 Sep.


Comparison of the mammalian insulin signalling pathway to invertebrates in the context of FOXO-mediated ageing.

Papatheodorou I, Petrovs R, Thornton JM.

Bioinformatics. 2014 Nov 1;30(21):2999-3003. doi: 10.1093/bioinformatics/btu493. Epub 2014 Jul 26.


Using association rule mining to determine promising secondary phenotyping hypotheses.

Oellrich A, Jacobsen J, Papatheodorou I; Sanger Mouse Genetics Project, Smedley D.

Bioinformatics. 2014 Jun 15;30(12):i52-59. doi: 10.1093/bioinformatics/btu260.


MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans.

Riesen M, Feyst I, Rattanavirotkul N, Ezcurra M, Tullet JM, Papatheodorou I, Ziehm M, Au C, Gilliat AF, Hellberg J, Thornton JM, Gems D.

Aging (Albany NY). 2014 Feb;6(2):98-117.


DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109. eCollection 2014 Feb.


Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster.

Ivanov DK, Papatheodorou I, Ziehm M, Thornton JM.

Mol Biosyst. 2013 Jul;9(7):1756-64. doi: 10.1039/c3mb25485b. Epub 2013 Apr 26.


Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.

Papatheodorou I, Ziehm M, Wieser D, Alic N, Partridge L, Thornton JM.

PLoS One. 2012;7(12):e50881. doi: 10.1371/journal.pone.0050881. Epub 2012 Dec 10.


Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.

Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cochemé HM, Schuster EF, Thornton JM, Partridge L.

Mol Syst Biol. 2011 Jun 21;7:502. doi: 10.1038/msb.2011.36.


Computational biology for ageing.

Wieser D, Papatheodorou I, Ziehm M, Thornton JM.

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 12;366(1561):51-63. doi: 10.1098/rstb.2010.0286. Review.


A metadata approach for clinical data management in translational genomics studies in breast cancer.

Papatheodorou I, Crichton C, Morris L, Maccallum P; METABRIC Group, Davies J, Brenton JD, Caldas C.

BMC Med Genomics. 2009 Nov 30;2:66. doi: 10.1186/1755-8794-2-66.


Visualization of microarray results to assist interpretation.

Papatheodorou I, Sergot M, Randall M, Stewart GR, Robertson BD.

Tuberculosis (Edinb). 2004;84(3-4):275-81.

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