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A lifelong duty: how Xist maintains the inactive X chromosome.
Jacobson EC, Pandya-Jones A, Plath K. Jacobson EC, et al. Among authors: pandya jones a. Curr Opin Genet Dev. 2022 Aug;75:101927. doi: 10.1016/j.gde.2022.101927. Epub 2022 Jun 16. Curr Opin Genet Dev. 2022. PMID: 35717799 Free PMC article. Review.
A protein assembly mediates Xist localization and gene silencing.
Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Mancia Leon WR, Damianov A, Chronis C, Papp B, Chen CK, McKee R, Wang XJ, Chau A, Sabri S, Leonhardt H, Zheng S, Guttman M, Black DL, Plath K. Pandya-Jones A, et al. Nature. 2020 Nov;587(7832):145-151. doi: 10.1038/s41586-020-2703-0. Epub 2020 Sep 9. Nature. 2020. PMID: 32908311 Free PMC article.
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.
McHugh CA, Chen CK, Chow A, Surka CF, Tran C, McDonel P, Pandya-Jones A, Blanco M, Burghard C, Moradian A, Sweredoski MJ, Shishkin AA, Su J, Lander ES, Hess S, Plath K, Guttman M. McHugh CA, et al. Among authors: pandya jones a. Nature. 2015 May 14;521(7551):232-6. doi: 10.1038/nature14443. Epub 2015 Apr 27. Nature. 2015. PMID: 25915022 Free PMC article.
11 results