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Results: 1 to 20 of 44

1.

Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors.

Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ, McGowan S.

J Med Chem. 2014 Oct 24. [Epub ahead of print]

PMID:
25299353
[PubMed - as supplied by publisher]
2.

Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.

Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9.

PMID:
24927554
[PubMed - indexed for MEDLINE]
3.

PLP-dependent enzymes.

Paiardini A, Contestabile R, Buckle AM, Cellini B.

Biomed Res Int. 2014;2014:856076. doi: 10.1155/2014/856076. Epub 2014 Jan 15. No abstract available.

PMID:
24527459
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The phytotoxin fusicoccin differently regulates 14-3-3 proteins association to mode III targets.

Paiardini A, Aducci P, Cervoni L, Cutruzzolà F, Di Lucente C, Janson G, Pascarella S, Rinaldo S, Visconti S, Camoni L.

IUBMB Life. 2014 Jan;66(1):52-62. doi: 10.1002/iub.1239. Epub 2014 Jan 10.

PMID:
24408864
[PubMed - indexed for MEDLINE]
5.

Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain.

Giardina G, Paiardini A, Fernicola S, Franceschini S, Rinaldo S, Stelitano V, Cutruzzolà F.

PLoS One. 2013 Nov 22;8(11):e81324. doi: 10.1371/journal.pone.0081324. eCollection 2013.

PMID:
24278422
[PubMed - in process]
Free PMC Article
6.

On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase.

di Salvo ML, Remesh SG, Vivoli M, Ghatge MS, Paiardini A, D'Aguanno S, Safo MK, Contestabile R.

FEBS J. 2014 Jan;281(1):129-45. doi: 10.1111/febs.12581. Epub 2013 Nov 13.

PMID:
24165453
[PubMed - indexed for MEDLINE]
7.

Type I pyridoxal 5'-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines.

Milano T, Paiardini A, Grgurina I, Pascarella S.

BMC Struct Biol. 2013 Oct 23;13:26. doi: 10.1186/1472-6807-13-26.

PMID:
24148833
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG.

Stelitano V, Giardina G, Paiardini A, Castiglione N, Cutruzzolà F, Rinaldo S.

PLoS One. 2013 Sep 16;8(9):e74920. doi: 10.1371/journal.pone.0074920. eCollection 2013.

PMID:
24066157
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum.

Kannan Sivaraman K, Paiardini A, Sieńczyk M, Ruggeri C, Oellig CA, Dalton JP, Scammells PJ, Drag M, McGowan S.

J Med Chem. 2013 Jun 27;56(12):5213-7. doi: 10.1021/jm4005972. Epub 2013 Jun 13.

PMID:
23713488
[PubMed - indexed for MEDLINE]
Free Article
10.

Crystal structure of the S187F variant of human liver alanine: glyoxylate [corrected] aminotransferase associated with primary hyperoxaluria type I and its functional implications.

Oppici E, Fodor K, Paiardini A, Williams C, Voltattorni CB, Wilmanns M, Cellini B.

Proteins. 2013 Aug;81(8):1457-65. doi: 10.1002/prot.24300. Epub 2013 Jun 1. Erratum in: Proteins. 2014 Jan;82(1):171.

PMID:
23589421
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability.

Antoniani D, Rossi E, Rinaldo S, Bocci P, Lolicato M, Paiardini A, Raffaelli N, Cutruzzolà F, Landini P.

Appl Microbiol Biotechnol. 2013 Aug;97(16):7325-36. doi: 10.1007/s00253-013-4875-0. Epub 2013 Apr 14.

PMID:
23584245
[PubMed - indexed for MEDLINE]
12.

Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study.

Paiardini A, Pascarella S.

Theor Biol Med Model. 2013 Apr 10;10:25. doi: 10.1186/1742-4682-10-25.

PMID:
23575112
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection.

di Salvo ML, Contestabile R, Paiardini A, Maras B.

Med Hypotheses. 2013 May;80(5):633-6. doi: 10.1016/j.mehy.2013.02.008. Epub 2013 Mar 6.

PMID:
23474074
[PubMed - indexed for MEDLINE]
14.

Alanine racemase from Tolypocladium inflatum: a key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity.

di Salvo ML, Florio R, Paiardini A, Vivoli M, D'Aguanno S, Contestabile R.

Arch Biochem Biophys. 2013 Jan 15;529(2):55-65. doi: 10.1016/j.abb.2012.11.011. Epub 2012 Dec 3.

PMID:
23219598
[PubMed - indexed for MEDLINE]
15.

Insight into the structure-function relationship of the nonheme iron halogenases involved in the biosynthesis of 4-chlorothreonine --Thr3 from Streptomyces sp. OH-5093 and SyrB2 from Pseudomonas syringae pv. syringae B301DR.

Fullone MR, Paiardini A, Miele R, Marsango S, Gross DC, Omura S, Ros-Herrera E, Bonaccorsi di Patti MC, Laganà A, Pascarella S, Grgurina I.

FEBS J. 2012 Dec;279(23):4269-82. doi: 10.1111/febs.12017. Epub 2012 Oct 30.

PMID:
23025743
[PubMed - indexed for MEDLINE]
16.

Rapid profiling of disease alleles using a tunable reporter of protein misfolding.

Pittman AM, Lage MD, Poltoratsky V, Vrana JD, Paiardini A, Roncador A, Cellini B, Hughes RM, Tucker CL.

Genetics. 2012 Nov;192(3):831-42. doi: 10.1534/genetics.112.143750. Epub 2012 Aug 24.

PMID:
22923379
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL.

Bramucci E, Paiardini A, Bossa F, Pascarella S.

BMC Bioinformatics. 2012 Mar 28;13 Suppl 4:S2. doi: 10.1186/1471-2105-13-S4-S2.

PMID:
22536966
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors.

Daidone F, Montioli R, Paiardini A, Cellini B, Macchiarulo A, Giardina G, Bossa F, Borri Voltattorni C.

PLoS One. 2012;7(2):e31610. doi: 10.1371/journal.pone.0031610. Epub 2012 Feb 23.

PMID:
22384042
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Molecular insights into primary hyperoxaluria type 1 pathogenesis.

Cellini B, Oppici E, Paiardini A, Montioli R.

Front Biosci (Landmark Ed). 2012 Jan 1;17:621-34. Review.

PMID:
22201765
[PubMed - indexed for MEDLINE]
20.

Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface.

Siglioccolo A, Paiardini A, Piscitelli M, Pascarella S.

BMC Struct Biol. 2011 Dec 22;11:50. doi: 10.1186/1472-6807-11-50.

PMID:
22192175
[PubMed - indexed for MEDLINE]
Free PMC Article

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