Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Dement Geriatr Cogn Disord. 2010;30(2):121-30. doi: 10.1159/000319537. Epub 2010 Aug 21.

An MRI-based semiquantitative index for the evaluation of brain atrophy and lesions in Alzheimer's disease, mild cognitive impairment and normal aging.

Author information

  • 1National Research Council Canada, Institute for Biodiagnostics (Atlantic), Halifax, N.S., Canada.

Abstract

BACKGROUND:

This study investigates how T(1)-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging.

METHODS:

A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets.

RESULTS:

The T(1)- and T(2)-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores.

CONCLUSION:

The T(1)-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

Copyright © 2010 S. Karger AG, Basel.

PMID:
20733305
[PubMed - indexed for MEDLINE]
PMCID:
PMC2969164
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Write to the Help Desk