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Genes Dev. 2010 Apr 1;24(7):653-8. doi: 10.1101/gad.1894310. Epub 2010 Mar 18.

MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development.

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  • 1Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

Abstract

Alternative splicing transitions have been identified recently as a conserved component of vertebrate heart remodeling during postnatal development. Here we report that the targeted deletion of Dicer, specifically in adult mouse myocardium, reveals the role of microRNAs (miRNAs) in regulating networks of postnatal splicing transitions and in maintaining adult splicing programs. We demonstrate a direct role for miR-23a/b in the dramatic postnatal down-regulation of CUGBP and ETR-3-like factor (CELF) proteins that regulate nearly half of developmentally regulated splicing transitions in the heart. These findings define a hierarchy in which rapid postnatal up-regulation of specific miRNAs controls expression of alternative splicing regulators and the subsequent splicing transitions of their downstream targets.

PMID:
20299448
[PubMed - indexed for MEDLINE]
PMCID:
PMC2849122
Free PMC Article

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