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Page 1
Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A.
Bao Z, Li A, Lu X, Wang Z, Yu Y, Wu W, Zhao L, Li B, Wu X, Laster KV, Zhang C, Jiang Y, Dong Z, Liu K. Bao Z, et al. Cell Death Dis. 2022 Feb 25;13(2):189. doi: 10.1038/s41419-022-04642-x. Cell Death Dis. 2022. PMID: 35217647 Free PMC article.
In the present study, we found that oxethazaine inhibited the proliferation and migration of esophageal cancer cells. ...Our findings suggest that oxethazaine can inhibit ESCC proliferation and metastasis in vitro and in vivo by targeting AURKA....
In the present study, we found that oxethazaine inhibited the proliferation and migration of esophageal cancer cells. ...Our findings …
Oxethazaine inhibits hepatitis B virus capsid assembly by blocking the cytosolic calcium-signalling pathway.
Zhang L, Liu C, Xiao Y, Chen X. Zhang L, et al. J Gen Virol. 2016 May;97(5):1198-1209. doi: 10.1099/jgv.0.000417. Epub 2016 Feb 1. J Gen Virol. 2016. PMID: 26838678
However, the levels of HBV cccDNA and HBV RNAs were not affected by oxethazaine treatment. Further study confirmed that oxethazaine acts on the virus assembly stage of the HBV life cycle. ...Moreover, oxethazaine could inhibit the replication of lamivudine/en …
However, the levels of HBV cccDNA and HBV RNAs were not affected by oxethazaine treatment. Further study confirmed that oxethazain …
Oxethazaine as the source of mephentermine and phentermine in athlete's urine.
Hsu MC, Lin SF, Kuan CP, Chu WL, Chan KH, Chang-Chien GP. Hsu MC, et al. Forensic Sci Int. 2009 Mar 10;185(1-3):e1-5. doi: 10.1016/j.forsciint.2008.12.009. Epub 2009 Jan 20. Forensic Sci Int. 2009. PMID: 19157735
Thus, oxethazaine is the source of mephentermine and phentermine. Moreover, the results showed that 48 brands of gastric medicines containing oxethazaine were legally imported or locally manufactured in Taiwan, information which could be useful for limiting the misu …
Thus, oxethazaine is the source of mephentermine and phentermine. Moreover, the results showed that 48 brands of gastric medicines co …
The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models.
Lee SY, You IJ, Kim MJ, Kwon SH, Hong SI, Kim JH, Jang MH, Oh SM, Chung KH, Lee SY, Jang CG. Lee SY, et al. Pharmacol Biochem Behav. 2013 Apr;105:98-104. doi: 10.1016/j.pbb.2013.01.022. Epub 2013 Feb 8. Pharmacol Biochem Behav. 2013. PMID: 23402942
Furthermore, oxethazaine and its metabolites in rat plasma were monitored using liquid chromatography-tandem mass spectrometry (LC-MS/MS) after oxethazaine administration, and compared with phentermine itself after phentermine administration to clarify the relations …
Furthermore, oxethazaine and its metabolites in rat plasma were monitored using liquid chromatography-tandem mass spectrometry (LC-MS …
A preliminary report using oxethazaine--a potential new dental local anaesthetic.
Brennan PA, Langdon JD. Brennan PA, et al. Br J Oral Maxillofac Surg. 1990 Feb;28(1):26-8. doi: 10.1016/0266-4356(90)90006-7. Br J Oral Maxillofac Surg. 1990. PMID: 2182107 Clinical Trial.
Currently, oxethazaine is used in an antacid preparation for the topical relief of pain in conditions such as hiatus hernia, where the local pH is very low. Since oxethazaine is active in an acidic environment, it was decided to use oxethazaine, in a pilot st …
Currently, oxethazaine is used in an antacid preparation for the topical relief of pain in conditions such as hiatus hernia, where th …
Inhibitory Effect of Oxethazaine on Midazolam Metabolism in Rats.
Namba H, Nishimura Y, Kurata N, Iwase M, Hirai T, Kiuchi Y. Namba H, et al. Biol Pharm Bull. 2017;40(9):1361-1365. doi: 10.1248/bpb.b16-01016. Biol Pharm Bull. 2017. PMID: 28867721 Free article.
This current study was conducted to clarify the DDIs through CYP3A inhibition by oxethazaine (OXZ), an antacid available as an OTC drug. Midazolam (MDZ) was used as a probe drug for CYP3A activity. ...
This current study was conducted to clarify the DDIs through CYP3A inhibition by oxethazaine (OXZ), an antacid available as an OTC dr …
Complexation of oxethazaine with 2-hydroxypropyl-beta-cyclodextrin: increased drug solubility, decreased cytotoxicity and analgesia at inflamed tissues.
Prado AR, Yokaichiya F, Franco MKKD, Silva CMGD, Oliveira-Nascimento L, Franz-Montan M, Volpato MC, Cabeça LF, de Paula E. Prado AR, et al. J Pharm Pharmacol. 2017 Jun;69(6):652-662. doi: 10.1111/jphp.12703. Epub 2017 Feb 17. J Pharm Pharmacol. 2017. PMID: 28211640
OBJECTIVES: Oxethazaine (OXZ) is one of the few local anaesthetics that provides analgesia at low pH, but presents poor solubility, cytotoxicity and no parenteral formulations. ...In vivo analgesia was tested by Von Frey test (inflammatory wounds - rats). KEY FINDINGS: …
OBJECTIVES: Oxethazaine (OXZ) is one of the few local anaesthetics that provides analgesia at low pH, but presents poor solubility, c …
A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration.
Zanni A, Gherardi S, Crowther PS, De Tomasi F, Scott CN, Bertoli R. Zanni A, et al. Curr Med Res Opin. 1986;10(2):128-34. doi: 10.1185/03007998609110430. Curr Med Res Opin. 1986. PMID: 3519093 Clinical Trial.
A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium hydroxide mixture with that of the antacid combination alone. ...Both trea …
A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain …
74 results