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Items: 20

1.

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells.

Wang X, Mazurkiewicz M, Hillert EK, Olofsson MH, Pierrou S, Hillertz P, Gullbo J, Selvaraju K, Paulus A, Akhtar S, Bossler F, Khan AC, Linder S, D'Arcy P.

Sci Rep. 2016 Jun 6;6:26979. doi: 10.1038/srep26979.

2.

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors.

Zhang X, de Milito A, Olofsson MH, Gullbo J, D'Arcy P, Linder S.

Int J Mol Sci. 2015 Nov 13;16(11):27313-26. doi: 10.3390/ijms161126020. Review.

3.

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.

Senkowski W, Zhang X, Olofsson MH, Isacson R, Höglund U, Gustafsson M, Nygren P, Linder S, Larsson R, Fryknäs M.

Mol Cancer Ther. 2015 Jun;14(6):1504-16. doi: 10.1158/1535-7163.MCT-14-0792. Epub 2015 Apr 24.

4.

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.

Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson MH, Gogvadze V, Dang L, Påhlman S, Schughart LA, Rickardson L, D'Arcy P, Gullbo J, Nygren P, Larsson R, Linder S.

Nat Commun. 2014;5:3295. doi: 10.1038/ncomms4295.

5.

Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats.

Samén E, Arnberg F, Lu L, Olofsson MH, Tegnebratt T, Thorell JO, Holmin S, Stone-Elander S.

J Nucl Med. 2013 Oct;54(10):1804-11. doi: 10.2967/jnumed.113.120493. Epub 2013 Sep 3.

6.

Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death.

Cheng Q, Lu L, Grafström J, Olofsson MH, Thorell JO, Samén E, Johansson K, Ahlzén HS, Linder S, Arnér ES, Stone-Elander S.

Biochim Biophys Acta. 2013 Mar;1830(3):2562-73.

7.

HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule.

Wållberg H, Grafström J, Cheng Q, Lu L, Martinsson Ahlzén HS, Samén E, Thorell JO, Johansson K, Dunås F, Olofsson MH, Stone-Elander S, Arnér ES, Ståhl S.

J Nucl Med. 2012 Sep;53(9):1446-53. doi: 10.2967/jnumed.111.102194. Epub 2012 Aug 7.

8.

Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.

Cheng Q, Lu L, Grafström J, Olofsson MH, Thorell JO, Samén E, Johansson K, Ahlzén HS, Stone-Elander S, Linder S, Arnér ES; Sel-tag Imaging Project.

PLoS One. 2012;7(8):e42151. doi: 10.1371/journal.pone.0042151. Epub 2012 Aug 1.

9.

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S.

Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7.

PMID:
22154651
10.

Inhibition of proteasome deubiquitinating activity as a new cancer therapy.

D'Arcy P, Brnjic S, Olofsson MH, Fryknäs M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S.

Nat Med. 2011 Nov 6;17(12):1636-40. doi: 10.1038/nm.2536.

PMID:
22057347
11.

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties.

Fayad W, Rickardson L, Haglund C, Olofsson MH, D'Arcy P, Larsson R, Linder S, Fryknäs M.

Chem Biol Drug Des. 2011 Oct;78(4):547-57. doi: 10.1111/j.1747-0285.2011.01170.x. Epub 2011 Jul 29.

PMID:
21726416
12.

Screening of natural products for therapeutic activity against solid tumors.

El-Menshawi BS, Fayad W, Mahmoud K, El-Hallouty SM, El-Manawaty M, Olofsson MH, Linder S.

Indian J Exp Biol. 2010 Mar;48(3):258-64.

PMID:
21046978
13.

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis.

Brnjic S, Olofsson MH, Havelka AM, Linder S.

Mol Biosyst. 2010 May;6(5):767-74. doi: 10.1039/b920805d. Epub 2010 Feb 9. Review.

PMID:
20567760
14.

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.

Linder S, Olofsson MH, Herrmann R, Ulukaya E.

Expert Rev Mol Diagn. 2010 Apr;10(3):353-9. doi: 10.1586/erm.10.14. Review.

PMID:
20370591
15.

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

Fayad W, Fryknäs M, Brnjic S, Olofsson MH, Larsson R, Linder S.

PLoS One. 2009 Oct 2;4(10):e7238. doi: 10.1371/journal.pone.0007238.

16.

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S.

Int J Cancer. 2009 Nov 15;125(10):2450-5. doi: 10.1002/ijc.24627.

17.

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.

Olofsson MH, Cummings J, Fayad W, Brnjic S, Herrmann R, Berndtsson M, Hodgkinson C, Dean E, Odedra R, Wilkinson RW, Mundt KE, Busk M, Dive C, Linder S.

Cancer Biomark. 2009;5(3):117-25. doi: 10.3233/CBM-2009-0597.

PMID:
19407366
18.

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH, Havelka AM, Brnjic S, Shoshan MC, Linder S.

BMC Chem Biol. 2008 Aug 1;8:2. doi: 10.1186/1472-6769-8-2.

19.

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC, Linder S.

Mini Rev Med Chem. 2007 Oct;7(10):1035-9. Review.

PMID:
17979806
20.

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.

Olofsson MH, Ueno T, Pan Y, Xu R, Cai F, van der Kuip H, Muerdter TE, Sonnenberg M, Aulitzky WE, Schwarz S, Andersson E, Shoshan MC, Havelka AM, Toi M, Linder S.

Clin Cancer Res. 2007 Jun 1;13(11):3198-206.

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