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Results: 17

1.

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments.

Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson MH, Gogvadze V, Dang L, Påhlman S, Schughart LA, Rickardson L, D'Arcy P, Gullbo J, Nygren P, Larsson R, Linder S.

Nat Commun. 2014;5:3295. doi: 10.1038/ncomms4295.

PMID:
24548894
[PubMed - in process]
Free PMC Article
2.

Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats.

Samén E, Arnberg F, Lu L, Olofsson MH, Tegnebratt T, Thorell JO, Holmin S, Stone-Elander S.

J Nucl Med. 2013 Oct;54(10):1804-11. doi: 10.2967/jnumed.113.120493. Epub 2013 Sep 3.

PMID:
24003078
[PubMed - indexed for MEDLINE]
3.

Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death.

Cheng Q, Lu L, Grafström J, Olofsson MH, Thorell JO, Samén E, Johansson K, Ahlzén HS, Linder S, Arnér ES, Stone-Elander S.

Biochim Biophys Acta. 2013 Mar;1830(3):2562-73.

PMID:
23262140
[PubMed - indexed for MEDLINE]
Free Article
4.

HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule.

Wållberg H, Grafström J, Cheng Q, Lu L, Martinsson Ahlzén HS, Samén E, Thorell JO, Johansson K, Dunås F, Olofsson MH, Stone-Elander S, Arnér ES, Ståhl S.

J Nucl Med. 2012 Sep;53(9):1446-53. doi: 10.2967/jnumed.111.102194. Epub 2012 Aug 7.

PMID:
22872744
[PubMed - indexed for MEDLINE]
Free Article
5.

Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.

Cheng Q, Lu L, Grafström J, Olofsson MH, Thorell JO, Samén E, Johansson K, Ahlzén HS, Stone-Elander S, Linder S, Arnér ES; Sel-tag Imaging Project.

PLoS One. 2012;7(8):e42151. doi: 10.1371/journal.pone.0042151. Epub 2012 Aug 1.

PMID:
22870292
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.

Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S.

Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7.

PMID:
22154651
[PubMed - indexed for MEDLINE]
7.

Inhibition of proteasome deubiquitinating activity as a new cancer therapy.

D'Arcy P, Brnjic S, Olofsson MH, Fryknäs M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S.

Nat Med. 2011 Nov 6;17(12):1636-40. doi: 10.1038/nm.2536.

PMID:
22057347
[PubMed - indexed for MEDLINE]
8.

Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties.

Fayad W, Rickardson L, Haglund C, Olofsson MH, D'Arcy P, Larsson R, Linder S, Fryknäs M.

Chem Biol Drug Des. 2011 Oct;78(4):547-57. doi: 10.1111/j.1747-0285.2011.01170.x. Epub 2011 Jul 29.

PMID:
21726416
[PubMed - indexed for MEDLINE]
9.

Screening of natural products for therapeutic activity against solid tumors.

El-Menshawi BS, Fayad W, Mahmoud K, El-Hallouty SM, El-Manawaty M, Olofsson MH, Linder S.

Indian J Exp Biol. 2010 Mar;48(3):258-64.

PMID:
21046978
[PubMed - indexed for MEDLINE]
10.

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis.

Brnjic S, Olofsson MH, Havelka AM, Linder S.

Mol Biosyst. 2010 May;6(5):767-74. doi: 10.1039/b920805d. Epub 2010 Feb 9. Review.

PMID:
20567760
[PubMed - indexed for MEDLINE]
11.

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies.

Linder S, Olofsson MH, Herrmann R, Ulukaya E.

Expert Rev Mol Diagn. 2010 Apr;10(3):353-9. doi: 10.1586/erm.10.14. Review.

PMID:
20370591
[PubMed - indexed for MEDLINE]
12.

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters.

Fayad W, Fryknäs M, Brnjic S, Olofsson MH, Larsson R, Linder S.

PLoS One. 2009 Oct 2;4(10):e7238. doi: 10.1371/journal.pone.0007238.

PMID:
19798419
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

Fayad W, Brnjic S, Berglind D, Blixt S, Shoshan MC, Berndtsson M, Olofsson MH, Linder S.

Int J Cancer. 2009 Nov 15;125(10):2450-5. doi: 10.1002/ijc.24627.

PMID:
19670329
[PubMed - indexed for MEDLINE]
14.

Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.

Olofsson MH, Cummings J, Fayad W, Brnjic S, Herrmann R, Berndtsson M, Hodgkinson C, Dean E, Odedra R, Wilkinson RW, Mundt KE, Busk M, Dive C, Linder S.

Cancer Biomark. 2009;5(3):117-25. doi: 10.3233/CBM-2009-0597.

PMID:
19407366
[PubMed - indexed for MEDLINE]
15.

Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II.

Olofsson MH, Havelka AM, Brnjic S, Shoshan MC, Linder S.

BMC Chem Biol. 2008 Aug 1;8:2. doi: 10.1186/1472-6769-8-2.

PMID:
18673549
[PubMed]
Free PMC Article
16.

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC, Linder S.

Mini Rev Med Chem. 2007 Oct;7(10):1035-9. Review.

PMID:
17979806
[PubMed - indexed for MEDLINE]
17.

Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy.

Olofsson MH, Ueno T, Pan Y, Xu R, Cai F, van der Kuip H, Muerdter TE, Sonnenberg M, Aulitzky WE, Schwarz S, Andersson E, Shoshan MC, Havelka AM, Toi M, Linder S.

Clin Cancer Res. 2007 Jun 1;13(11):3198-206.

PMID:
17545523
[PubMed - indexed for MEDLINE]
Free Article

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