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Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage.

Retailleau K, Arhatte M, Demolombe S, Jodar M, Baudrie V, Offermanns S, Feng Y, Patel A, Honoré E, Duprat F.

Pflugers Arch. 2016 Mar 29. [Epub ahead of print]


GNA13 loss in germinal center B cells leads to impaired apoptosis and GC B cell persistence and promotes lymphoma in vivo.

Healy JA, Nugent A, Rempel RE, Moffitt AB, Davis NS, Jiang X, Shingleton JR, Zhang J, Love C, Datta J, McKinney ME, Tzeng TJ, Wettschureck N, Offermanns S, Walzer KA, Chi JT, Rasheed SA, Casey PJ, Lossos IS, Dave SS.

Blood. 2016 Mar 17. pii: blood-2015-07-659938. [Epub ahead of print]


Arterial Myogenic Activation through Smooth Muscle Filamin A.

Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, Bourreau J, Henrion D, Offermanns S, Nakamura F, Feng Y, Patel A, Duprat F, Honoré E.

Cell Rep. 2016 Mar 8;14(9):2050-8. doi: 10.1016/j.celrep.2016.02.019. Epub 2016 Feb 25.


G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.

Li YQ, Shrestha Y, Pandey M, Chen M, Kablan A, Gavrilova O, Offermanns S, Weinstein LS.

J Clin Invest. 2016 Jan;126(1):40-9. doi: 10.1172/JCI76348. Epub 2015 Nov 23.


Age-dependent blood pressure elevation is due to increased vascular smooth muscle tone mediated by G-protein signalling.

Wirth A, Wang S, Takefuji M, Tang C, Althoff TF, Schweda F, Wettschureck N, Offermanns S.

Cardiovasc Res. 2016 Jan 1;109(1):131-40. doi: 10.1093/cvr/cvv249. Epub 2015 Nov 3.


Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling.

Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honoré E.

Cell Rep. 2015 Nov 10;13(6):1161-71. doi: 10.1016/j.celrep.2015.09.072. Epub 2015 Oct 29.


Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity.

Masuda M, Miyazaki-Anzai S, Keenan AL, Okamura K, Kendrick J, Chonchol M, Offermanns S, Ntambi JM, Kuro-O M, Miyazaki M.

J Clin Invest. 2015 Oct 26;125(12):4544-58. doi: 10.1172/JCI82871.


Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.

Grunddal KV, Ratner CF, Svendsen B, Sommer F, Engelstoft MS, Madsen AN, Pedersen J, Nøhr MK, Egerod KL, Nawrocki AR, Kowalski T, Howard AD, Poulsen SS, Offermanns S, Bäckhed F, Holst JJ, Holst B, Schwartz TW.

Endocrinology. 2016 Jan;157(1):176-94. doi: 10.1210/en.2015-1600. Epub 2015 Oct 15.


Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action.

Schreier B, Hünerberg M, Rabe S, Mildenberger S, Bethmann D, Heise C, Sibilia M, Offermanns S, Gekle M.

Clin Sci (Lond). 2016 Jan;130(1):19-33. doi: 10.1042/CS20150503. Epub 2015 Oct 5.


GnRH Neuron-Specific Ablation of Gαq/11 Results in Only Partial Inactivation of the Neuroendocrine-Reproductive Axis in Both Male and Female Mice: In Vivo Evidence for Kiss1r-Coupled Gαq/11-Independent GnRH Secretion.

Babwah AV, Navarro VM, Ahow M, Pampillo M, Nash C, Fayazi M, Calder M, Elbert A, Urbanski HF, Wettschureck N, Offermanns S, Carroll RS, Bhattacharya M, Tobet SA, Kaiser UB.

J Neurosci. 2015 Sep 16;35(37):12903-16. doi: 10.1523/JNEUROSCI.0041-15.2015.


Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.

Williams CM, Harper MT, Goggs R, Walsh TG, Offermanns S, Poole AW.

J Thromb Haemost. 2015 Nov;13(11):2102-7. doi: 10.1111/jth.13129. Epub 2015 Oct 20.


Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis.

Sivaraj KK, Li R, Albarran-Juarez J, Wang S, Tischner D, Grimm M, Swiercz JM, Offermanns S, Wettschureck N.

Cardiovasc Res. 2015 Oct 1;108(1):171-80. doi: 10.1093/cvr/cvv216. Epub 2015 Aug 13.


Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.

Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):384-93. doi: 10.1165/rcmb.2015-0151OC.


P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction.

Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S.

J Clin Invest. 2015 Aug 3;125(8):3077-86. doi: 10.1172/JCI81067. Epub 2015 Jul 13.


Therapeutically Targeting Tumor Necrosis Factor-α/Sphingosine-1-Phosphate Signaling Corrects Myogenic Reactivity in Subarachnoid Hemorrhage.

Yagi K, Lidington D, Wan H, Fares JC, Meissner A, Sumiyoshi M, Ai J, Foltz WD, Nedospasov SA, Offermanns S, Nagahiro S, Macdonald RL, Bolz SS.

Stroke. 2015 Aug;46(8):2260-70. doi: 10.1161/STROKEAHA.114.006365. Epub 2015 Jul 2.


Inducible human endothelin-1 overexpression in endothelium raises blood pressure via endothelin type A receptors.

Rautureau Y, Coelho SC, Fraulob-Aquino JC, Huo KG, Rehman A, Offermanns S, Paradis P, Schiffrin EL.

Hypertension. 2015 Aug;66(2):347-55. doi: 10.1161/HYPERTENSIONAHA.115.05168. Epub 2015 Jun 22.


G-protein-mediated signaling in vascular smooth muscle cells - implications for vascular disease.

Althoff TF, Offermanns S.

J Mol Med (Berl). 2015 Sep;93(9):973-81. doi: 10.1007/s00109-015-1305-z. Epub 2015 Jun 14.


Response to letter regarding article, "Vitamin D promotes vascular regeneration".

Ka Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP.

Circulation. 2015 Jun 2;131(22):e515-6. doi: 10.1161/CIRCULATIONAHA.114.014781. No abstract available.


Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.

Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T.

Dev Cell. 2015 May 4;33(3):299-313. doi: 10.1016/j.devcel.2015.02.001. Epub 2015 Apr 16.


Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis.

Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC, Fernández-Hernando C.

Circ Res. 2015 May 22;116(11):1744-52. doi: 10.1161/CIRCRESAHA.116.305895. Epub 2015 Apr 13.

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