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Results: 1 to 20 of 271

1.

An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.

Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.

Nat Genet. 2014 Sep 14. doi: 10.1038/ng.3089. [Epub ahead of print]

PMID:
25217959
[PubMed - as supplied by publisher]
2.

Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ.

Immunol Rev. 2014 Sep;261(1):23-49. doi: 10.1111/imr.12208.

PMID:
25123275
[PubMed - in process]
3.

Enhancing the understanding of asthma.

Vahedi G, Richard AC, O'Shea JJ.

Nat Immunol. 2014 Aug;15(8):701-3. doi: 10.1038/ni.2946. No abstract available.

PMID:
25045871
[PubMed - in process]
4.

Proliferation conditions promote intrinsic changes in NK cells for an IL-10 response.

Tarrio ML, Lee SH, Fragoso MF, Sun HW, Kanno Y, O'Shea JJ, Biron CA.

J Immunol. 2014 Jul 1;193(1):354-63. doi: 10.4049/jimmunol.1302999. Epub 2014 Jun 6.

PMID:
24907347
[PubMed - indexed for MEDLINE]
5.

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts.

Onda M, Ghoreschi K, Steward-Tharp S, Thomas C, O'Shea JJ, Pastan IH, FitzGerald DJ.

J Immunol. 2014 Jul 1;193(1):48-55. doi: 10.4049/jimmunol.1400063. Epub 2014 Jun 2.

PMID:
24890727
[PubMed - indexed for MEDLINE]
6.

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.

Bonelli M, Shih HY, Hirahara K, Singelton K, Laurence A, Poholek A, Hand T, Mikami Y, Vahedi G, Kanno Y, O'Shea JJ.

Curr Top Microbiol Immunol. 2014;381:279-326. doi: 10.1007/82_2014_371.

PMID:
24831346
[PubMed - in process]
7.

In search of magic bullets: the golden age of immunotherapeutics.

O'Shea JJ, Kanno Y, Chan AC.

Cell. 2014 Mar 27;157(1):227-40. doi: 10.1016/j.cell.2014.03.010. Review.

PMID:
24679538
[PubMed - indexed for MEDLINE]
8.

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.

Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.

PMID:
24632714
[PubMed - indexed for MEDLINE]
9.

Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.

Nakayamada S, Poholek AC, Lu KT, Takahashi H, Kato M, Iwata S, Hirahara K, Cannons JL, Schwartzberg PL, Vahedi G, Sun HW, Kanno Y, O'Shea JJ.

J Immunol. 2014 Mar 1;192(5):2156-66. doi: 10.4049/jimmunol.1300675. Epub 2014 Jan 31.

PMID:
24489092
[PubMed - indexed for MEDLINE]
10.

Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib.

Okiyama N, Furumoto Y, Villarroel VA, Linton JT, Tsai WL, Gutermuth J, Ghoreschi K, Gadina M, O'Shea JJ, Katz SI.

J Invest Dermatol. 2014 Apr;134(4):992-1000. doi: 10.1038/jid.2013.476. Epub 2013 Nov 8.

PMID:
24213371
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A degrading view of regulatory T cells.

Laurence A, Belkaid Y, O'Shea JJ.

Immunity. 2013 Aug 22;39(2):201-3. doi: 10.1016/j.immuni.2013.08.017.

PMID:
23973216
[PubMed - indexed for MEDLINE]
12.

BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.

Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciumè G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP.

Nature. 2013 Jun 27;498(7455):506-10. doi: 10.1038/nature12199. Epub 2013 Jun 2.

PMID:
23728300
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.

Hirahara K, Poholek A, Vahedi G, Laurence A, Kanno Y, Milner JD, O'Shea JJ.

J Allergy Clin Immunol. 2013 May;131(5):1276-87. doi: 10.1016/j.jaci.2013.03.015. Review.

PMID:
23622118
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers.

Vahedi G, Kanno Y, Sartorelli V, O'Shea JJ.

Immunology. 2013 Jul;139(3):294-8. doi: 10.1111/imm.12113. Review.

PMID:
23586907
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Tissue inhibitor of metalloproteinase 1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene.

Adamson A, Ghoreschi K, Rittler M, Chen Q, Sun HW, Vahedi G, Kanno Y, Stetler-Stevenson WG, O'Shea JJ, Laurence A.

PLoS One. 2013;8(3):e59367. doi: 10.1371/journal.pone.0059367. Epub 2013 Mar 26.

PMID:
23555662
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Janus kinase inhibitors in autoimmune diseases.

O'Shea JJ, Kontzias A, Yamaoka K, Tanaka Y, Laurence A.

Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii111-5. doi: 10.1136/annrheumdis-2012-202576. Review.

PMID:
23532440
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Autoimmunity: Rubbing salt in the wound.

O'Shea JJ, Jones RG.

Nature. 2013 Apr 25;496(7446):437-9. doi: 10.1038/nature11959. Epub 2013 Mar 6. No abstract available.

PMID:
23467087
[PubMed - indexed for MEDLINE]
18.

Back to the future: oral targeted therapy for RA and other autoimmune diseases.

O'Shea JJ, Laurence A, McInnes IB.

Nat Rev Rheumatol. 2013 Mar;9(3):173-82. doi: 10.1038/nrrheum.2013.7. Epub 2013 Feb 19. Review.

PMID:
23419429
[PubMed - indexed for MEDLINE]
19.

Helper T-cell identity and evolution of differential transcriptomes and epigenomes.

Vahedi G, C Poholek A, Hand TW, Laurence A, Kanno Y, O'Shea JJ, Hirahara K.

Immunol Rev. 2013 Mar;252(1):24-40. doi: 10.1111/imr.12037. Review.

PMID:
23405893
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

JAKs and STATs in immunity, immunodeficiency, and cancer.

O'Shea JJ, Holland SM, Staudt LM.

N Engl J Med. 2013 Jan 10;368(2):161-70. doi: 10.1056/NEJMra1202117. Review. No abstract available.

PMID:
23301733
[PubMed - indexed for MEDLINE]

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