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Progressive accumulation of the abnormal conformer of the prion protein and spongiform encephalopathy in the obex of nonsymptomatic and symptomatic Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease.

Spraker TR, Gidlewski T, Powers JG, Nichols T, Balachandran A, Cummings B, Wild MA, VerCauteren K, O'Rourke KI.

J Vet Diagn Invest. 2015 Jul 16. pii: 1040638715593368. [Epub ahead of print]


PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay.

Madsen-Bouterse SA, Schneider DA, Dassanayake RP, Truscott TC, Zhuang D, Kumpula-McWhirter N, O'Rourke KI.

J Vet Diagn Invest. 2015 May;27(3):332-43. doi: 10.1177/1040638715585865.


Role of the PRNP S127 allele in experimental infection of goats with classical caprine scrapie.

Dassanayake RP, White SN, Madsen-Bouterse SA, Schneider DA, O'Rourke KI.

Anim Genet. 2015 Jun;46(3):341. doi: 10.1111/age.12291. No abstract available.


The placenta shed from goats with classical scrapie is infectious to goat kids and lambs.

Schneider DA, Madsen-Bouterse SA, Zhuang D, Truscott TC, Dassanayake RP, O'Rourke KI.

J Gen Virol. 2015 Apr 17. pii: vir.0.000151. doi: 10.1099/vir.0.000151. [Epub ahead of print]


Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays.

Dassanayake RP, Truscott TC, Zhuang D, Schneider DA, Madsen-Bouterse SA, Young AJ, Stanton JB, Davis WC, O'Rourke KI.

J Vet Sci. 2015 Jun;16(2):179-86. Epub 2014 Dec 24.


Immunization with a synthetic peptide vaccine fails to protect mule deer (Odocoileus hemionus) from chronic wasting disease.

Pilon JL, Rhyan JC, Wolfe LL, Davis TR, McCollum MP, O'Rourke KI, Spraker TR, VerCauteren KC, Miller MW, Gidlewski T, Nichols TA, Miller LA, Nol P.

J Wildl Dis. 2013 Jul;49(3):694-8. doi: 10.7589/2012-07-200.


Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep.

Dassanayake RP, Truscott TC, Özyiğit MÖ, Zhuang D, Schneider DA, O'Rourke KI.

BMC Vet Res. 2013 Apr 19;9:82. doi: 10.1186/1746-6148-9-82.


Efficacy of antemortem rectal biopsies to diagnose and estimate prevalence of chronic wasting disease in free-ranging cow elk (Cervus elaphus nelsoni).

Monello RJ, Powers JG, Hobbs NT, Spraker TR, O'Rourke KI, Wild MA.

J Wildl Dis. 2013 Apr;49(2):270-8. doi: 10.7589/2011-12-362.


Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America: effects of age, sex, polymorphism at PRNP codon 96, and disease progression.

Thomsen BV, Schneider DA, O'Rourke KI, Gidlewski T, McLane J, Allen RW, McIsaac AA, Mitchell GB, Keane DP, Spraker TR, Balachandran A.

J Vet Diagn Invest. 2012 Sep;24(5):878-87. doi: 10.1177/1040638712453582.


Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus).

Mitchell GB, Sigurdson CJ, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A.

PLoS One. 2012;7(6):e39055. doi: 10.1371/journal.pone.0039055. Epub 2012 Jun 18.


Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay.

Madsen-Bouterse SA, Zhuang D, O'Rourke KI, Schneider DA.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):770-4. doi: 10.1016/j.bbrc.2012.06.034. Epub 2012 Jun 16.


Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy.

Schneider DA, Harrington RD, Zhuang D, Yan H, Truscott TC, Dassanayake RP, O'Rourke KI.

J Comp Pathol. 2012 Nov;147(4):508-21. doi: 10.1016/j.jcpa.2012.03.008. Epub 2012 May 16.


Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222.

White SN, Reynolds JO, Waldron DF, Schneider DA, O'Rourke KI.

Gene. 2012 Jun 10;501(1):49-51. doi: 10.1016/j.gene.2012.03.068. Epub 2012 Apr 4.


Transmissibility of caprine scrapie in ovine transgenic mice.

O'Rourke KI, Schneider DA, Spraker TR, Dassanayake RP, Highland MA, Zhuang D, Truscott TC.

BMC Vet Res. 2012 Apr 2;8:42. doi: 10.1186/1746-6148-8-42.


The role of genetics in chronic wasting disease of North American cervids.

Robinson SJ, Samuel MD, O'Rourke KI, Johnson CJ.

Prion. 2012 Apr-Jun;6(2):153-62. doi: 10.4161/pri.19640. Epub 2012 Apr 1. Review.


Cell-surface expression of PrPC and the presence of scrapie prions in the blood of goats.

Dassanayake RP, Schneider DA, Herrmann-Hoesing LM, Truscott TC, Davis WC, O'Rourke KI.

J Gen Virol. 2012 May;93(Pt 5):1127-31. doi: 10.1099/vir.0.039032-0. Epub 2012 Jan 25.


Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma.

Dassanayake RP, Schneider DA, Truscott TC, Young AJ, Zhuang D, O'Rourke KI.

BMC Vet Res. 2011 Nov 23;7:75. doi: 10.1186/1746-6148-7-75.


Failure of fallow deer (Dama dama) to develop chronic wasting disease when exposed to a contaminated environment and infected mule deer (Odocoileus hemionus).

Rhyan JC, Miller MW, Spraker TR, McCollum M, Nol P, Wolfe LL, Davis TR, Creekmore L, O'Rourke KI.

J Wildl Dis. 2011 Jul;47(3):739-44.


Sparse PrP(Sc) accumulation in the placentas of goats with naturally acquired scrapie.

O'Rourke KI, Zhuang D, Truscott TC, Yan H, Schneider DA.

BMC Vet Res. 2011 Feb 1;7:7. doi: 10.1186/1746-6148-7-7.


Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk.

White SN, Spraker TR, Reynolds JO, O'Rourke KI.

BMC Res Notes. 2010 Nov 18;3:314. doi: 10.1186/1756-0500-3-314.

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