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MEMHDX: An interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.

Hourdel V, Volant S, O'Brien DP, Chenal A, Chamot-Rooke J, Dillies MA, Brier S.

Bioinformatics. 2016 Jul 13. pii: btw420. [Epub ahead of print]


Risk factors for unstructured treatment interruptions and association with survival in low to middle income countries.

McMahon JH, Spelman T, Ford N, Greig J, Mesic A, Ssonko C, Casas EC, O'Brien DP.

AIDS Res Ther. 2016 Jul 11;13:25. doi: 10.1186/s12981-016-0109-8. eCollection 2016.


Australian Cattle Dogs with Neuronal Ceroid Lipofuscinosis are Homozygous for a CLN5 Nonsense Mutation Previously Identified in Border Collies.

Kolicheski A, Johnson GS, O'Brien DP, Mhlanga-Mutangadura T, Gilliam D, Guo J, Anderson-Sieg TD, Schnabel RD, Taylor JF, Lebowitz A, Swanson B, Hicks D, Niman ZE, Wininger FA, Carpentier MC, Katz ML.

J Vet Intern Med. 2016 May 20. doi: 10.1111/jvim.13971. [Epub ahead of print]


A Homozygous RAB3GAP1:c.743delC Mutation in Rottweilers with Neuronal Vacuolation and Spinocerebellar Degeneration.

Mhlanga-Mutangadura T, Johnson GS, Ashwini A, Shelton GD, Wennogle SA, Johnson GC, Kuroki K, O'Brien DP.

J Vet Intern Med. 2016 May;30(3):813-8. doi: 10.1111/jvim.13921. Epub 2016 Mar 10.


Increasing Experience with Primary Oral Medical Therapy for Mycobacterium ulcerans Disease in an Australian Cohort.

Friedman ND, Athan E, Walton AL, O'Brien DP.

Antimicrob Agents Chemother. 2016 Apr 22;60(5):2692-5. doi: 10.1128/AAC.02853-15. Print 2016 May.


Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.

Marsden CD, Ortega-Del Vecchyo D, O'Brien DP, Taylor JF, Ramirez O, Vilà C, Marques-Bonet T, Schnabel RD, Wayne RK, Lohmueller KE.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):152-7. doi: 10.1073/pnas.1512501113. Epub 2015 Dec 22.


Sublimation in bright spots on (1) Ceres.

Nathues A, Hoffmann M, Schaefer M, Le Corre L, Reddy V, Platz T, Cloutis EA, Christensen U, Kneissl T, Li JY, Mengel K, Schmedemann N, Schaefer T, Russell CT, Applin DM, Buczkowski DL, Izawa MR, Keller HU, O'Brien DP, Pieters CM, Raymond CA, Ripken J, Schenk PM, Schmidt BE, Sierks H, Sykes MV, Thangjam GS, Vincent JB.

Nature. 2015 Dec 10;528(7581):237-40. doi: 10.1038/nature15754.


Mycobacterium ulcerans in the Elderly: More Severe Disease and Suboptimal Outcomes.

O'Brien DP, Friedman ND, Cowan R, Pollard J, McDonald A, Callan P, Hughes A, Athan E.

PLoS Negl Trop Dis. 2015 Dec 2;9(12):e0004253. doi: 10.1371/journal.pntd.0004253. eCollection 2015 Dec.


A mutation in the Warburg syndrome gene, RAB3GAP1, causes a similar syndrome with polyneuropathy and neuronal vacuolation in Black Russian Terrier dogs.

Mhlanga-Mutangadura T, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Katz ML, Shelton GD, Lever TE, Giuliano E, Granger N, Shomper J, O'Brien DP.

Neurobiol Dis. 2016 Feb;86:75-85. doi: 10.1016/j.nbd.2015.11.016. Epub 2015 Nov 25.


Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.

Jenkinson C, Elliott VL, Evans A, Oldfield L, Jenkins RE, O'Brien DP, Apostolidou S, Gentry-Maharaj A, Fourkala EO, Jacobs IJ, Menon U, Cox T, Campbell F, Pereira SP, Tuveson DA, Park BK, Greenhalf W, Sutton R, Timms JF, Neoptolemos JP, Costello E.

Clin Cancer Res. 2016 Apr 1;22(7):1734-43. doi: 10.1158/1078-0432.CCR-15-0879. Epub 2015 Nov 16.


Generating Evidence to Improve the Response to Neglected Diseases: How Operational Research in a Médecins Sans Frontières Buruli Ulcer Treatment Programme Informed International Management Guidance.

O'Brien DP, Ford N, Vitoria M, Asiedu K, Calmy A, Du Cros P, Comte E, Christinet V.

PLoS Negl Trop Dis. 2015 Nov 12;9(11):e0004075. doi: 10.1371/journal.pntd.0004075. eCollection 2015 Nov. No abstract available.


Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.

O'Brien DP, Hernandez B, Durand D, Hourdel V, Sotomayor-Pérez AC, Vachette P, Ghomi M, Chamot-Rooke J, Ladant D, Brier S, Chenal A.

Sci Rep. 2015 Sep 16;5:14223. doi: 10.1038/srep14223.


A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.

Rohdin C, Gilliam D, O'Leary CA, O'Brien DP, Coates JR, Johnson GS, Jäderlund KH.

Acta Vet Scand. 2015 May 23;57:26. doi: 10.1186/s13028-015-0115-1.


Pre-emptive steroids for a severe oedematous Buruli ulcer lesion: a case report.

O'Brien DP, Huffam S.

J Med Case Rep. 2015 May 1;9:98. doi: 10.1186/s13256-015-0584-x.


Understanding genetics: why should vets care?

Jones BR, Little S, Lyons LA, Malik R, Nicholas F, O'Brien DP, Pedersen NC.

J Feline Med Surg. 2015 Mar;17(3):201-2. doi: 10.1177/1098612X15571877. No abstract available.


Mycobacterium ulcerans treatment--can antibiotic duration be reduced in selected patients?

Cowan R, Athan E, Friedman ND, Hughes AJ, McDonald A, Callan P, Fyfe J, O'Brien DP.

PLoS Negl Trop Dis. 2015 Feb 6;9(2):e0003503. doi: 10.1371/journal.pntd.0003503. eCollection 2015 Feb.


A rare homozygous MFSD8 single-base-pair deletion and frameshift in the whole genome sequence of a Chinese Crested dog with neuronal ceroid lipofuscinosis.

Guo J, O'Brien DP, Mhlanga-Mutangadura T, Olby NJ, Taylor JF, Schnabel RD, Katz ML, Johnson GS.

BMC Vet Res. 2015 Jan 3;10:960. doi: 10.1186/s12917-014-0181-z.


A novel mutation in CLCN1 associated with feline myotonia congenita.

Gandolfi B, Daniel RJ, O'Brien DP, Guo LT, Youngs MD, Leach SB, Jones BR, Shelton GD, Lyons LA.

PLoS One. 2014 Oct 30;9(10):e109926. doi: 10.1371/journal.pone.0109926. eCollection 2014.


Clinical features and management of a severe paradoxical reaction associated with combined treatment of Buruli ulcer and HIV co-infection.

Wanda F, Nkemenang P, Ehounou G, Tchaton M, Comte E, Toutous Trellu L, Masouyé I, Christinet V, O'Brien DP.

BMC Infect Dis. 2014 Jul 30;14:423. doi: 10.1186/1471-2334-14-423.


Moxifloxacin for Buruli ulcer/HIV-coinfected patients: kill two birds with one stone? Author reply.

O'Brien DP, Comte E, Ford N, Christinet V, Du Cros P.

AIDS. 2014 Jul 31;28(12):1845-6. doi: 10.1097/QAD.0000000000000304. No abstract available.

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