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Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.

Wang B, Zhao L, Fish M, Logan CY, Nusse R.

Nature. 2015 Aug 13;524(7564):180-5. doi: 10.1038/nature14863. Epub 2015 Aug 5.


Wnt/β-Catenin-Responsive Cells in Prostatic Development and Regeneration.

Lee SH, Johnson DT, Luong R, Yu EJ, Cunha GR, Nusse R, Sun Z.

Stem Cells. 2015 Jul 29. doi: 10.1002/stem.2096. [Epub ahead of print]


A distinct regulatory region of the Bmp5 locus activates gene expression following adult bone fracture or soft tissue injury.

Guenther CA, Wang Z, Li E, Tran MC, Logan CY, Nusse R, Pantalena-Filho L, Yang GP, Kingsley DM.

Bone. 2015 Aug;77:31-41. doi: 10.1016/j.bone.2015.04.010. Epub 2015 Apr 14.


Cell signalling: Disarming Wnt.

Nusse R.

Nature. 2015 Mar 12;519(7542):163-4. doi: 10.1038/nature14208. Epub 2015 Feb 25. No abstract available.


Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.

Sigal M, Rothenberg ME, Logan CY, Lee JY, Honaker RW, Cooper RL, Passarelli B, Camorlinga M, Bouley DM, Alvarez G, Nusse R, Torres J, Amieva MR.

Gastroenterology. 2015 Jun;148(7):1392-404.e21. doi: 10.1053/j.gastro.2015.02.049. Epub 2015 Feb 26.


Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation.

Tan SH, Senarath-Yapa K, Chung MT, Longaker MT, Wu JY, Nusse R.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5262-71. doi: 10.1073/pnas.1420463111. Epub 2014 Nov 24.


Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control.

Clevers H, Loh KM, Nusse R.

Science. 2014 Oct 3;346(6205):1248012. doi: 10.1126/science.1248012. Epub 2014 Oct 2. Review.


In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration.

Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, Lim X, Van-Amerongen R, Bowman A, Januszyk M, Pleniceanu O, Nusse R, Longaker MT, Weissman IL, Dekel B.

Cell Rep. 2014 May 22;7(4):1270-83. doi: 10.1016/j.celrep.2014.04.018. Epub 2014 May 15.


The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction.

Green J, Nusse R, van Amerongen R.

Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2). pii: a009175. doi: 10.1101/cshperspect.a009175. Review.


Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling.

Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R.

Science. 2013 Dec 6;342(6163):1226-30. doi: 10.1126/science.1239730.


Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation.

Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CV, Gu G, Kim SK.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12691-6. doi: 10.1073/pnas.1304507110. Epub 2013 Jul 12.


structural Studies of Wnts and identification of an LRP6 binding site.

Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI.

Structure. 2013 Jul 2;21(7):1235-42. doi: 10.1016/j.str.2013.05.006. Epub 2013 Jun 20.


Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells.

Bowman AN, van Amerongen R, Palmer TD, Nusse R.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7324-9. doi: 10.1073/pnas.1305411110. Epub 2013 Apr 15.


Paracrine Wnt signaling both promotes and inhibits human breast tumor growth.

Green JL, La J, Yum KW, Desai P, Rodewald LW, Zhang X, Leblanc M, Nusse R, Lewis MT, Wahl GM.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6991-6. doi: 10.1073/pnas.1303671110. Epub 2013 Apr 4.


A localized Wnt signal orients asymmetric stem cell division in vitro.

Habib SJ, Chen BC, Tsai FC, Anastassiadis K, Meyer T, Betzig E, Nusse R.

Science. 2013 Mar 22;339(6126):1445-8. doi: 10.1126/science.1231077. Erratum in: Science. 2013 May 24;340(6135):924.


Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells.

Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG.

Development. 2013 Mar;140(6):1196-206. doi: 10.1242/dev.087528.


Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.

Ardehali R, Ali SR, Inlay MA, Abilez OJ, Chen MQ, Blauwkamp TA, Yazawa M, Gong Y, Nusse R, Drukker M, Weissman IL.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3405-10. doi: 10.1073/pnas.1220832110. Epub 2013 Feb 7.


Wnt signaling in skin development, homeostasis, and disease.

Lim X, Nusse R.

Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2). pii: a008029. doi: 10.1101/cshperspect.a008029. Review.


Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.

Blauwkamp TA, Nigam S, Ardehali R, Weissman IL, Nusse R.

Nat Commun. 2012;3:1070. doi: 10.1038/ncomms2064.


Wnt proteins.

Willert K, Nusse R.

Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a007864. doi: 10.1101/cshperspect.a007864. Review.

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