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Items: 4


A new antibiotic kills pathogens without detectable resistance.

Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K.

Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Erratum in: Nature. 2015 Apr 16;520(7547):388.


Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.

Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis K.

Chem Biol. 2014 Apr 24;21(4):509-18. doi: 10.1016/j.chembiol.2014.01.014. Epub 2014 Mar 27.


Isofuranonaphthoquinone produced by an Actinoplanes isolate.

Zhang Q, Peoples AJ, Rothfeder MT, Millett WP, Pescatore BC, Ling LL, Moore CM.

J Nat Prod. 2009 Jun;72(6):1213-5. doi: 10.1021/np8005716.


Neocitreamicins I and II, novel antibiotics with activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci.

Peoples AJ, Zhang Q, Millett WP, Rothfeder MT, Pescatore BC, Madden AA, Ling LL, Moore CM.

J Antibiot (Tokyo). 2008 Jul;61(7):457-63. doi: 10.1038/ja.2008.62.

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