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Results: 1 to 20 of 66

1.

Improved identification of dystonic cervical muscles via abnormal muscle activity during isometric contractions.

De Bruijn E, Nijmeijer SW, Forbes PA, Koelman JH, van der Helm FC, Tijssen MA, Happee R.

J Neurol Sci. 2015 Jul 15;354(1-2):10-6. doi: 10.1016/j.jns.2015.03.047. Epub 2015 Apr 9.

PMID:
25972112
2.

Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms.

Monk KR, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I.

Mol Pharmacol. 2015 Sep;88(3):617-23. doi: 10.1124/mol.115.098749. Epub 2015 May 8.

PMID:
25956432
3.

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.

de Munnik SM, Kooistra AJ, van Offenbeek J, Nijmeijer S, de Graaf C, Smit MJ, Leurs R, Vischer HF.

PLoS One. 2015 Apr 20;10(4):e0124486. doi: 10.1371/journal.pone.0124486. eCollection 2015.

4.

Combinatorial Consensus Scoring for Ligand-Based Virtual Fragment Screening: A Comparative Case Study for Serotonin 5-HT(3)A, Histamine H(1), and Histamine H(4) Receptors.

Schultes S, Kooistra AJ, Vischer HF, Nijmeijer S, Haaksma EE, Leurs R, de Esch IJ, de Graaf C.

J Chem Inf Model. 2015 May 26;55(5):1030-44. doi: 10.1021/ci500694c. Epub 2015 Apr 23.

PMID:
25815783
5.

EMG coherence and spectral analysis in cervical dystonia: discriminative tools to identify dystonic muscles?

Nijmeijer SW, de Bruijn E, Forbes PA, Kamphuis DJ, Happee R, Koelman JH, Tijssen MA.

J Neurol Sci. 2014 Dec 15;347(1-2):167-73. doi: 10.1016/j.jns.2014.09.041. Epub 2014 Oct 2.

PMID:
25305713
6.

Anti-N-methyl-D-aspartate receptor encephalitis in a pre-teenage girl: a case report.

Nijmeijer S, Bontemps S, Naeije L, Coutinho J.

Eur J Pediatr. 2014 May;173(5):681-3. doi: 10.1007/s00431-013-2042-3. Epub 2013 May 24.

PMID:
23703469
7.

Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.

Engelhardt H, Schultes S, de Graaf C, Nijmeijer S, Vischer HF, Zuiderveld OP, Dobler J, Stachurski K, Mayer M, Arnhof H, Scharn D, Haaksma EE, de Esch IJ, Leurs R.

J Med Chem. 2013 Jun 13;56(11):4264-76. doi: 10.1021/jm301886t. Epub 2013 May 28.

PMID:
23668417
8.

Phytoestrogens in menopausal supplements induce ER-dependent cell proliferation and overcome breast cancer treatment in an in vitro breast cancer model.

van Duursen MB, Smeets EE, Rijk JC, Nijmeijer SM, van den Berg M.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):132-40. doi: 10.1016/j.taap.2013.03.014. Epub 2013 Mar 28.

PMID:
23541764
9.

Cervical dystonia: improved treatment response to botulinum toxin after referral to a tertiary centre and the use of polymyography.

Nijmeijer SW, Koelman JH, Standaar TS, Postma M, Tijssen MA.

Parkinsonism Relat Disord. 2013 May;19(5):533-8. doi: 10.1016/j.parkreldis.2013.01.018. Epub 2013 Mar 7.

10.

Detailed analysis of biased histamine H₄ receptor signalling by JNJ 7777120 analogues.

Nijmeijer S, Vischer HF, Sirci F, Schultes S, Engelhardt H, de Graaf C, Rosethorne EM, Charlton SJ, Leurs R.

Br J Pharmacol. 2013 Sep;170(1):78-88. doi: 10.1111/bph.12117.

11.

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor.

Nijmeijer S, Engelhardt H, Schultes S, van de Stolpe AC, Lusink V, de Graaf C, Wijtmans M, Haaksma EE, de Esch IJ, Stachurski K, Vischer HF, Leurs R.

Br J Pharmacol. 2013 Sep;170(1):89-100. doi: 10.1111/bph.12113.

12.

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.

de Graaf C, Vischer HF, de Kloe GE, Kooistra AJ, Nijmeijer S, Kuijer M, Verheij MH, England PJ, van Muijlwijk-Koezen JE, Leurs R, de Esch IJ.

Drug Discov Today. 2013 Apr;18(7-8):323-30. doi: 10.1016/j.drudis.2012.12.003. Epub 2012 Dec 22.

PMID:
23266367
13.

Virtual fragment screening: discovery of histamine H3 receptor ligands using ligand-based and protein-based molecular fingerprints.

Sirci F, Istyastono EP, Vischer HF, Kooistra AJ, Nijmeijer S, Kuijer M, Wijtmans M, Mannhold R, Leurs R, de Esch IJ, de Graaf C.

J Chem Inf Model. 2012 Dec 21;52(12):3308-24. doi: 10.1021/ci3004094. Epub 2012 Dec 3.

PMID:
23140085
14.

Analysis of multiple histamine H₄ receptor compound classes uncovers Gαi protein- and β-arrestin2-biased ligands.

Nijmeijer S, Vischer HF, Rosethorne EM, Charlton SJ, Leurs R.

Mol Pharmacol. 2012 Dec;82(6):1174-82. doi: 10.1124/mol.112.080911. Epub 2012 Sep 12.

15.

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer S, Vischer HF, Rudebeck AF, Fleurbaaij F, Falck D, Leurs R, Niessen WM, Kool J.

J Biomol Screen. 2012 Dec;17(10):1329-38. doi: 10.1177/1087057112451922. Epub 2012 Jun 26.

PMID:
22740245
16.

Molecular pharmacology of histamine H4 receptors.

Nijmeijer S, de Graaf C, Leurs R, Vischer HF.

Front Biosci (Landmark Ed). 2012 Jun 1;17:2089-106. Review.

PMID:
22652766
17.

Muscle selection for treatment of cervical dystonia with botulinum toxin--a systematic review.

Nijmeijer SW, Koelman JH, Kamphuis DJ, Tijssen MA.

Parkinsonism Relat Disord. 2012 Jul;18(6):731-6. doi: 10.1016/j.parkreldis.2012.04.005. Epub 2012 May 8. Review.

PMID:
22575237
18.

High-resolution metabolic profiling towards G protein-coupled receptors: rapid and comprehensive screening of histamine H₄ receptor ligands.

Kool J, Rudebeck AF, Fleurbaaij F, Nijmeijer S, Falck D, Smits RA, Vischer HF, Leurs R, Niessen WM.

J Chromatogr A. 2012 Oct 12;1259:213-20. doi: 10.1016/j.chroma.2012.03.052. Epub 2012 Mar 22.

PMID:
22520160
19.

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.

Istyastono EP, Nijmeijer S, Lim HD, van de Stolpe A, Roumen L, Kooistra AJ, Vischer HF, de Esch IJ, Leurs R, de Graaf C.

J Med Chem. 2011 Dec 8;54(23):8136-47. doi: 10.1021/jm201042n. Epub 2011 Nov 7.

PMID:
22003888
20.

Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.

Antolino-Lobo I, Meulenbelt J, Molendijk J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB.

Toxicology. 2011 Nov 18;289(2-3):175-84. doi: 10.1016/j.tox.2011.08.012. Epub 2011 Aug 17.

PMID:
21871945
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