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Results: 1 to 20 of 61

1.

Anti-N-methyl-D-aspartate receptor encephalitis in a pre-teenage girl: a case report.

Nijmeijer S, Bontemps S, Naeije L, Coutinho J.

Eur J Pediatr. 2014 May;173(5):681-3. doi: 10.1007/s00431-013-2042-3. Epub 2013 May 24.

PMID:
23703469
[PubMed - in process]
2.

Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.

Engelhardt H, Schultes S, de Graaf C, Nijmeijer S, Vischer HF, Zuiderveld OP, Dobler J, Stachurski K, Mayer M, Arnhof H, Scharn D, Haaksma EE, de Esch IJ, Leurs R.

J Med Chem. 2013 Jun 13;56(11):4264-76. doi: 10.1021/jm301886t. Epub 2013 May 28.

PMID:
23668417
[PubMed - indexed for MEDLINE]
3.

Phytoestrogens in menopausal supplements induce ER-dependent cell proliferation and overcome breast cancer treatment in an in vitro breast cancer model.

van Duursen MB, Smeets EE, Rijk JC, Nijmeijer SM, van den Berg M.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):132-40. doi: 10.1016/j.taap.2013.03.014. Epub 2013 Mar 28.

PMID:
23541764
[PubMed - indexed for MEDLINE]
4.

Cervical dystonia: improved treatment response to botulinum toxin after referral to a tertiary centre and the use of polymyography.

Nijmeijer SW, Koelman JH, Standaar TS, Postma M, Tijssen MA.

Parkinsonism Relat Disord. 2013 May;19(5):533-8. doi: 10.1016/j.parkreldis.2013.01.018. Epub 2013 Mar 7.

PMID:
23466060
[PubMed - indexed for MEDLINE]
Free Article
5.

Detailed analysis of biased histamine H₄ receptor signalling by JNJ 7777120 analogues.

Nijmeijer S, Vischer HF, Sirci F, Schultes S, Engelhardt H, de Graaf C, Rosethorne EM, Charlton SJ, Leurs R.

Br J Pharmacol. 2013 Sep;170(1):78-88. doi: 10.1111/bph.12117.

PMID:
23351115
[PubMed - in process]
6.

Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor.

Nijmeijer S, Engelhardt H, Schultes S, van de Stolpe AC, Lusink V, de Graaf C, Wijtmans M, Haaksma EE, de Esch IJ, Stachurski K, Vischer HF, Leurs R.

Br J Pharmacol. 2013 Sep;170(1):89-100. doi: 10.1111/bph.12113.

PMID:
23347159
[PubMed - in process]
7.

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.

de Graaf C, Vischer HF, de Kloe GE, Kooistra AJ, Nijmeijer S, Kuijer M, Verheij MH, England PJ, van Muijlwijk-Koezen JE, Leurs R, de Esch IJ.

Drug Discov Today. 2013 Apr;18(7-8):323-30. doi: 10.1016/j.drudis.2012.12.003. Epub 2012 Dec 22.

PMID:
23266367
[PubMed - indexed for MEDLINE]
8.

Virtual fragment screening: discovery of histamine H3 receptor ligands using ligand-based and protein-based molecular fingerprints.

Sirci F, Istyastono EP, Vischer HF, Kooistra AJ, Nijmeijer S, Kuijer M, Wijtmans M, Mannhold R, Leurs R, de Esch IJ, de Graaf C.

J Chem Inf Model. 2012 Dec 21;52(12):3308-24. doi: 10.1021/ci3004094. Epub 2012 Dec 3.

PMID:
23140085
[PubMed - indexed for MEDLINE]
9.

Analysis of multiple histamine H₄ receptor compound classes uncovers Gαi protein- and β-arrestin2-biased ligands.

Nijmeijer S, Vischer HF, Rosethorne EM, Charlton SJ, Leurs R.

Mol Pharmacol. 2012 Dec;82(6):1174-82. doi: 10.1124/mol.112.080911. Epub 2012 Sep 12.

PMID:
22973061
[PubMed - indexed for MEDLINE]
Free Article
10.

Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based GPCR signaling.

Nijmeijer S, Vischer HF, Rudebeck AF, Fleurbaaij F, Falck D, Leurs R, Niessen WM, Kool J.

J Biomol Screen. 2012 Dec;17(10):1329-38. doi: 10.1177/1087057112451922. Epub 2012 Jun 26.

PMID:
22740245
[PubMed - indexed for MEDLINE]
11.

Molecular pharmacology of histamine H4 receptors.

Nijmeijer S, de Graaf C, Leurs R, Vischer HF.

Front Biosci (Landmark Ed). 2012 Jun 1;17:2089-106. Review.

PMID:
22652766
[PubMed - indexed for MEDLINE]
12.

Muscle selection for treatment of cervical dystonia with botulinum toxin--a systematic review.

Nijmeijer SW, Koelman JH, Kamphuis DJ, Tijssen MA.

Parkinsonism Relat Disord. 2012 Jul;18(6):731-6. doi: 10.1016/j.parkreldis.2012.04.005. Epub 2012 May 8. Review.

PMID:
22575237
[PubMed - indexed for MEDLINE]
13.

High-resolution metabolic profiling towards G protein-coupled receptors: rapid and comprehensive screening of histamine H₄ receptor ligands.

Kool J, Rudebeck AF, Fleurbaaij F, Nijmeijer S, Falck D, Smits RA, Vischer HF, Leurs R, Niessen WM.

J Chromatogr A. 2012 Oct 12;1259:213-20. doi: 10.1016/j.chroma.2012.03.052. Epub 2012 Mar 22.

PMID:
22520160
[PubMed - indexed for MEDLINE]
14.

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.

Istyastono EP, Nijmeijer S, Lim HD, van de Stolpe A, Roumen L, Kooistra AJ, Vischer HF, de Esch IJ, Leurs R, de Graaf C.

J Med Chem. 2011 Dec 8;54(23):8136-47. doi: 10.1021/jm201042n. Epub 2011 Nov 7.

PMID:
22003888
[PubMed - indexed for MEDLINE]
15.

Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants.

Antolino-Lobo I, Meulenbelt J, Molendijk J, Nijmeijer SM, Scherpenisse P, van den Berg M, van Duursen MB.

Toxicology. 2011 Nov 18;289(2-3):175-84. doi: 10.1016/j.tox.2011.08.012. Epub 2011 Aug 17.

PMID:
21871945
[PubMed - indexed for MEDLINE]
16.

Genistein induces breast cancer-associated aromatase and stimulates estrogen-dependent tumor cell growth in in vitro breast cancer model.

van Duursen MB, Nijmeijer SM, de Morree ES, de Jong PC, van den Berg M.

Toxicology. 2011 Nov 18;289(2-3):67-73. doi: 10.1016/j.tox.2011.07.005. Epub 2011 Aug 10.

PMID:
21854827
[PubMed - indexed for MEDLINE]
17.

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

Verheij MH, de Graaf C, de Kloe GE, Nijmeijer S, Vischer HF, Smits RA, Zuiderveld OP, Hulscher S, Silvestri L, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5460-4. doi: 10.1016/j.bmcl.2011.06.123. Epub 2011 Jul 2.

PMID:
21782429
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Real-time visualization of heterotrimeric G protein Gq activation in living cells.

Adjobo-Hermans MJ, Goedhart J, van Weeren L, Nijmeijer S, Manders EM, Offermanns S, Gadella TW Jr.

BMC Biol. 2011 May 27;9:32. doi: 10.1186/1741-7007-9-32.

PMID:
21619590
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition.

Antolino-Lobo I, Meulenbelt J, Nijmeijer SM, Maas-Bakker RF, Meijerman I, van den Berg M, van Duursen MB.

Toxicol Lett. 2011 May 30;203(1):82-91. doi: 10.1016/j.toxlet.2011.03.007. Epub 2011 Mar 22.

PMID:
21402137
[PubMed - indexed for MEDLINE]
20.

Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.

Wijtmans M, de Graaf C, de Kloe G, Istyastono EP, Smit J, Lim H, Boonnak R, Nijmeijer S, Smits RA, Jongejan A, Zuiderveld O, de Esch IJ, Leurs R.

J Med Chem. 2011 Mar 24;54(6):1693-703. doi: 10.1021/jm1013488. Epub 2011 Feb 24.

PMID:
21348462
[PubMed - indexed for MEDLINE]

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