PubMed

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates.

Verheyen J, Verhofstede C, Knops E, Vandekerckhove L, Fun A, Brunen D, Dauwe K, Wensing A, Pfister H, Kaiser R, Nijhuis M.

AIDS. 2009 Nov 18. [Epub ahead of print]PMID: 19926962 [PubMed - as supplied by publisher]Related articles

Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance.

Wensing AM, van Maarseveen NM, Nijhuis M.

Antiviral Res. 2009 Oct 22. [Epub ahead of print]PMID: 19853627 [PubMed - as supplied by publisher]Related articles

Failure of treatment with first-line lopinavir boosted with ritonavir can be explained by novel resistance pathways with protease mutation 76V.

Nijhuis M, Wensing AM, Bierman WF, de Jong D, Kagan R, Fun A, Jaspers CA, Schurink KA, van Agtmael MA, Boucher CA.

J Infect Dis. 2009 Sep 1;200(5):698-709.PMID: 19627247 [PubMed - indexed for MEDLINE]Related articles

Novel mechanisms of HIV protease inhibitor resistance.

Nijhuis M, van Maarseveen NM, Verheyen J, Boucher CA.

Curr Opin HIV AIDS. 2008 Nov;3(6):627-32.PMID: 19373034 [PubMed - in process]Related articles

HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review.

Bierman WF, van Agtmael MA, Nijhuis M, Danner SA, Boucher CA.

AIDS. 2009 Jan 28;23(3):279-91. Review.PMID: 19114854 [PubMed - indexed for MEDLINE]Related articles

Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region.

Kozísek M, Sasková KG, Rezácová P, Brynda J, van Maarseveen NM, De Jong D, Boucher CA, Kagan RM, Nijhuis M, Konvalinka J.

J Virol. 2008 Jun;82(12):5869-78. Epub 2008 Apr 9.PMID: 18400858 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a novel resistance (E40F) and compensatory (K43E) substitution in HIV-1 reverse transcriptase.

Huigen MC, van Ham PM, de Graaf L, Kagan RM, Boucher CA, Nijhuis M.

Retrovirology. 2008 Feb 13;5:20.PMID: 18271957 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced severity of virus associated lower respiratory tract disease in asthma patients may not be associated with delayed viral clearance and increased viral load in the upper respiratory tract.

van Elden LJ, Sachs AP, van Loon AM, Haarman M, van de Vijver DA, Kimman TG, Zuithoff P, Schipper PJ, Verheij TJ, Nijhuis M.

J Clin Virol. 2008 Feb;41(2):116-21. Epub 2007 Dec 21.PMID: 18096430 [PubMed - indexed for MEDLINE]Related articles

Increased detection of respiratory syncytial virus, influenza viruses, parainfluenza viruses, and adenoviruses with real-time PCR in samples from patients with respiratory symptoms.

van de Pol AC, van Loon AM, Wolfs TF, Jansen NJ, Nijhuis M, Breteler EK, Schuurman R, Rossen JW.

J Clin Microbiol. 2007 Jul;45(7):2260-2. Epub 2007 May 16.PMID: 17507513 [PubMed - indexed for MEDLINE]Related articlesFree article

Evolution of a novel 5-amino-acid insertion in the beta3-beta4 loop of HIV-1 reverse transcriptase.

Huigen MC, de Graaf L, Eggink D, Schuurman R, Müller V, Stamp A, Stammers DK, Boucher CA, Nijhuis M.

Virology. 2007 Aug 1;364(2):395-406. Epub 2007 Apr 23.PMID: 17451772 [PubMed - indexed for MEDLINE]Related articles

Insertions in the beta3-beta4 loop of reverse transcriptase of human immunodeficiency virus type 1 and their mechanism of action, influence on drug susceptibility and viral replication capacity.

Eggink D, Huigen MC, Boucher CA, Götte M, Nijhuis M.

Antiviral Res. 2007 Aug;75(2):93-103. Epub 2007 Mar 26. Review.PMID: 17416429 [PubMed - indexed for MEDLINE]Related articles

HIV protease resistance and viral fitness.

Nijhuis M, van Maarseveen NM, Boucher CA.

Curr Opin HIV AIDS. 2007 Mar;2(2):108-15.PMID: 19372875 [PubMed - in process]Related articles

HIV-1 transmission cluster with M41L 'singleton' mutation and decreased transmission of resistance in newly diagnosed Swedish homosexual men.

Lindström A, Ohlis A, Huigen M, Nijhuis M, Berglund T, Bratt G, Sandström E, Albert J.

Antivir Ther. 2006;11(8):1031-9.PMID: 17302373 [PubMed - indexed for MEDLINE]Related articles

A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism.

Nijhuis M, van Maarseveen NM, Lastere S, Schipper P, Coakley E, Glass B, Rovenska M, de Jong D, Chappey C, Goedegebuure IW, Heilek-Snyder G, Dulude D, Cammack N, Brakier-Gingras L, Konvalinka J, Parkin N, Kräusslich HG, Brun-Vezinet F, Boucher CA.

PLoS Med. 2007 Jan;4(1):e36.PMID: 17227139 [PubMed - indexed for MEDLINE]Related articlesFree article

Persistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation.

van Maarseveen NM, Wensing AM, de Jong D, Taconis M, Borleffs JC, Boucher CA, Nijhuis M.

J Infect Dis. 2007 Feb 1;195(3):399-409. Epub 2006 Dec 29.PMID: 17205479 [PubMed - indexed for MEDLINE]Related articles

An increase in viral replicative capacity drives the evolution of protease inhibitor-resistant human immunodeficiency virus type 1 in the absence of drugs.

van Maarseveen NM, de Jong D, Boucher CA, Nijhuis M.

J Acquir Immune Defic Syndr. 2006 Jun;42(2):162-8.PMID: 16645546 [PubMed - indexed for MEDLINE]Related articles

IL-12 deficiency transiently improves viral clearance during the late phase of respiratory tract infection with influenza A virus in mice.

van der Sluijs KF, van Elden LJ, Xiao Y, Arens R, Nijhuis M, Schuurman R, Florquin S, Jansen HM, Lutter R, van der Poll T.

Antiviral Res. 2006 Jun;70(2):75-84. Epub 2006 Feb 9.PMID: 16490265 [PubMed - indexed for MEDLINE]Related articles

Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia.

van der Sluijs KF, Nijhuis M, Levels JH, Florquin S, Mellor AL, Jansen HM, van der Poll T, Lutter R.

J Infect Dis. 2006 Jan 15;193(2):214-22. Epub 2005 Dec 14.PMID: 16362885 [PubMed - indexed for MEDLINE]Related articles

Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia.

van der Sluijs KF, van Elden LJ, Nijhuis M, Schuurman R, Florquin S, Shimizu T, Ishii S, Jansen HM, Lutter R, van der Poll T.

Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L194-9. Epub 2005 Aug 12.PMID: 16100290 [PubMed - indexed for MEDLINE]Related articlesFree article

Frequent detection of respiratory viruses in adult recipients of stem cell transplants with the use of real-time polymerase chain reaction, compared with viral culture.

van Kraaij MG, van Elden LJ, van Loon AM, Hendriksen KA, Laterveer L, Dekker AW, Nijhuis M.

Clin Infect Dis. 2005 Mar 1;40(5):662-9. Epub 2005 Feb 7.PMID: 15714410 [PubMed - indexed for MEDLINE]Related articles