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Results: 1 to 20 of 185

1.

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC.

Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13.

PMID:
26279568
2.

Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC.

J Biol Chem. 2015 Jul 17. pii: jbc.M115.676221. [Epub ahead of print]

3.

The Relative Impact of Climate Change on the Extinction Risk of Tree Species in the Montane Tropical Andes.

Tejedor Garavito N, Newton AC, Golicher D, Oldfield S.

PLoS One. 2015 Jul 15;10(7):e0131388. doi: 10.1371/journal.pone.0131388. eCollection 2015.

4.

Habitat Fragmentation Intensifies Trade-Offs between Biodiversity and Ecosystem Services in a Heathland Ecosystem in Southern England.

Cordingley JE, Newton AC, Rose RJ, Clarke RT, Bullock JM.

PLoS One. 2015 Jun 26;10(6):e0130004. doi: 10.1371/journal.pone.0130004. eCollection 2015.

5.

A meta-analysis of functional group responses to forest recovery outside of the tropics.

Spake R, Ezard TH, Martin PA, Newton AC, Doncaster CP.

Conserv Biol. 2015 Jun 3. doi: 10.1111/cobi.12548. [Epub ahead of print]

PMID:
26040756
6.

Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.

Bradley EW, Carpio LR, Newton AC, Westendorf JJ.

J Biol Chem. 2015 Jun 26;290(26):16272-80. doi: 10.1074/jbc.M114.612937. Epub 2015 May 7.

PMID:
25953896
7.

Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E937-46. doi: 10.1073/pnas.1420140112. Epub 2015 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1509.

8.

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC.

Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22.

PMID:
25619690
9.

Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Kunkel MT, Newton AC.

Chem Biol. 2015 Jan 22;22(1):98-106. doi: 10.1016/j.chembiol.2014.11.014. Epub 2014 Dec 31.

PMID:
25556943
10.

Molecular effects of resistance elicitors from biological origin and their potential for crop protection.

Wiesel L, Newton AC, Elliott I, Booty D, Gilroy EM, Birch PR, Hein I.

Front Plant Sci. 2014 Nov 21;5:655. doi: 10.3389/fpls.2014.00655. eCollection 2014. Review.

11.

Tuning the signalling output of protein kinase C.

Antal CE, Newton AC.

Biochem Soc Trans. 2014 Dec;42(6):1477-83. doi: 10.1042/BST20140172. Review.

PMID:
25399557
12.

Intraspecific genetic diversity and composition modify species-level diversity-productivity relationships.

Schöb C, Kerle S, Karley AJ, Morcillo L, Pakeman RJ, Newton AC, Brooker RW.

New Phytol. 2015 Jan;205(2):720-30. doi: 10.1111/nph.13043. Epub 2014 Sep 24.

PMID:
25250812
13.

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3957-65. doi: 10.1073/pnas.1404221111. Epub 2014 Sep 8.

14.

Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.

Sierecki E, Newton AC.

Biochemistry. 2014 Jun 24;53(24):3971-81. doi: 10.1021/bi500428j. Epub 2014 Jun 12.

15.

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD.

Mol Cell. 2014 May 8;54(3):378-91. doi: 10.1016/j.molcel.2014.03.007. Epub 2014 Apr 3.

16.

Understanding the genetic control and physiological traits associated with rhizosheath production by barley (Hordeum vulgare).

George TS, Brown LK, Ramsay L, White PJ, Newton AC, Bengough AG, Russell J, Thomas WT.

New Phytol. 2014 Jul;203(1):195-205. doi: 10.1111/nph.12786. Epub 2014 Mar 28.

PMID:
24684319
17.

Intramolecular conformational changes optimize protein kinase C signaling.

Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC.

Chem Biol. 2014 Apr 24;21(4):459-69. doi: 10.1016/j.chembiol.2014.02.008. Epub 2014 Mar 13.

18.

Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.

Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE.

J Biol Chem. 2014 Mar 28;289(13):8781-98. doi: 10.1074/jbc.M113.533265. Epub 2014 Feb 5.

19.

Turning off AKT: PHLPP as a drug target.

Newton AC, Trotman LC.

Annu Rev Pharmacol Toxicol. 2014;54:537-58. doi: 10.1146/annurev-pharmtox-011112-140338. Review.

20.

Carbon pools recover more quickly than plant biodiversity in tropical secondary forests.

Martin PA, Newton AC, Bullock JM.

Proc Biol Sci. 2013 Nov 6;280(1773):20132236. doi: 10.1098/rspb.2013.2236. Print 2013 Dec 22. Erratum in: Proc Biol Sci. 2014 May 7;281(1782):20140303.

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