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Protein scaffolds control localized protein kinase C ζ Activity.

Tobias IS, Newton AC.

J Biol Chem. 2016 May 3. pii: jbc.M116.729483. [Epub ahead of print]


Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival.

Dowling CM, Phelan J, Callender JA, Cathcart MC, Mehigan B, McCormick P, Dalton T, Coffey JC, Newton AC, O'Sullivan J, Kiely PA.

Oncotarget. 2016 Mar 14. doi: 10.18632/oncotarget.8062. [Epub ahead of print]


Similar biodiversity of ectomycorrhizal fungi in set-aside plantations and ancient old-growth broadleaved forests.

Spake R, van der Linde S, Newton AC, Suz LM, Bidartondo MI, Doncaster CP.

Biol Conserv. 2016 Feb;194:71-79.


Drivers of the composition and diversity of carabid functional traits in UK coniferous plantations.

Spake R, Barsoum N, Newton AC, Doncaster CP.

For Ecol Manage. 2016 Jan 1;359:300-308.


Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.

Tobias IS, Kaulich M, Kim PK, Simon N, Jacinto E, Dowdy SF, King CC, Newton AC.

Biochem J. 2016 Feb 15;473(4):509-23. doi: 10.1042/BJ20151013. Epub 2015 Dec 3.


Rotational diffusion affects the dynamical self-assembly pathways of patchy particles.

Newton AC, Groenewold J, Kegel WK, Bolhuis PG.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15308-13. doi: 10.1073/pnas.1513210112. Epub 2015 Nov 30.


A transcriptional reference map of defence hormone responses in potato.

Wiesel L, Davis JL, Milne L, Redondo Fernandez V, Herold MB, Middlefell Williams J, Morris J, Hedley PE, Harrower B, Newton AC, Birch PR, Gilroy EM, Hein I.

Sci Rep. 2015 Oct 19;5:15229. doi: 10.1038/srep15229.


Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC.

Cell Rep. 2015 Aug 25;12(8):1252-60. doi: 10.1016/j.celrep.2015.07.039. Epub 2015 Aug 13.


Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62.

Tsai LC, Xie L, Dore K, Xie L, Del Rio JC, King CC, Martinez-Ariza G, Hulme C, Malinow R, Bourne PE, Newton AC.

J Biol Chem. 2015 Sep 4;290(36):21845-56. doi: 10.1074/jbc.M115.676221. Epub 2015 Jul 17.


The Relative Impact of Climate Change on the Extinction Risk of Tree Species in the Montane Tropical Andes.

Tejedor Garavito N, Newton AC, Golicher D, Oldfield S.

PLoS One. 2015 Jul 15;10(7):e0131388. doi: 10.1371/journal.pone.0131388. eCollection 2015.


Habitat Fragmentation Intensifies Trade-Offs between Biodiversity and Ecosystem Services in a Heathland Ecosystem in Southern England.

Cordingley JE, Newton AC, Rose RJ, Clarke RT, Bullock JM.

PLoS One. 2015 Jun 26;10(6):e0130004. doi: 10.1371/journal.pone.0130004. eCollection 2015.


A meta-analysis of functional group responses to forest recovery outside of the tropics.

Spake R, Ezard TH, Martin PA, Newton AC, Doncaster CP.

Conserv Biol. 2015 Dec;29(6):1695-703. doi: 10.1111/cobi.12548. Epub 2015 Jun 3.


Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.

Bradley EW, Carpio LR, Newton AC, Westendorf JJ.

J Biol Chem. 2015 Jun 26;290(26):16272-80. doi: 10.1074/jbc.M114.612937. Epub 2015 May 7.


Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E937-46. doi: 10.1073/pnas.1420140112. Epub 2015 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1509.


Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC.

Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22.


Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Kunkel MT, Newton AC.

Chem Biol. 2015 Jan 22;22(1):98-106. doi: 10.1016/j.chembiol.2014.11.014. Epub 2014 Dec 31.


Molecular effects of resistance elicitors from biological origin and their potential for crop protection.

Wiesel L, Newton AC, Elliott I, Booty D, Gilroy EM, Birch PR, Hein I.

Front Plant Sci. 2014 Nov 21;5:655. doi: 10.3389/fpls.2014.00655. eCollection 2014. Review.


Tuning the signalling output of protein kinase C.

Antal CE, Newton AC.

Biochem Soc Trans. 2014 Dec;42(6):1477-83. doi: 10.1042/BST20140172. Review.


Intraspecific genetic diversity and composition modify species-level diversity-productivity relationships.

Schöb C, Kerle S, Karley AJ, Morcillo L, Pakeman RJ, Newton AC, Brooker RW.

New Phytol. 2015 Jan;205(2):720-30. doi: 10.1111/nph.13043. Epub 2014 Sep 24.


Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3957-65. doi: 10.1073/pnas.1404221111. Epub 2014 Sep 8.

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