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Results: 1 to 20 of 179

1.

Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.

Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E937-46. doi: 10.1073/pnas.1420140112. Epub 2015 Feb 17.

PMID:
25713130
2.

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor.

Antal CE, Hudson AM, Kang E, Zanca C, Wirth C, Stephenson NL, Trotter EW, Gallegos LL, Miller CJ, Furnari FB, Hunter T, Brognard J, Newton AC.

Cell. 2015 Jan 29;160(3):489-502. doi: 10.1016/j.cell.2015.01.001. Epub 2015 Jan 22.

PMID:
25619690
3.

Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation.

Kunkel MT, Newton AC.

Chem Biol. 2015 Jan 22;22(1):98-106. doi: 10.1016/j.chembiol.2014.11.014. Epub 2014 Dec 31.

PMID:
25556943
4.

Molecular effects of resistance elicitors from biological origin and their potential for crop protection.

Wiesel L, Newton AC, Elliott I, Booty D, Gilroy EM, Birch PR, Hein I.

Front Plant Sci. 2014 Nov 21;5:655. doi: 10.3389/fpls.2014.00655. eCollection 2014. Review.

5.

Tuning the signalling output of protein kinase C.

Antal CE, Newton AC.

Biochem Soc Trans. 2014 Dec;42(6):1477-83. doi: 10.1042/BST20140172.

PMID:
25399557
6.

Intraspecific genetic diversity and composition modify species-level diversity-productivity relationships.

Schöb C, Kerle S, Karley AJ, Morcillo L, Pakeman RJ, Newton AC, Brooker RW.

New Phytol. 2015 Jan;205(2):720-30. doi: 10.1111/nph.13043. Epub 2014 Sep 24.

PMID:
25250812
7.

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E3957-65. doi: 10.1073/pnas.1404221111. Epub 2014 Sep 8.

8.

Biochemical characterization of the phosphatase domain of the tumor suppressor PH domain leucine-rich repeat protein phosphatase.

Sierecki E, Newton AC.

Biochemistry. 2014 Jun 24;53(24):3971-81. doi: 10.1021/bi500428j. Epub 2014 Jun 12.

PMID:
24892992
9.

Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD.

Mol Cell. 2014 May 8;54(3):378-91. doi: 10.1016/j.molcel.2014.03.007. Epub 2014 Apr 3.

PMID:
24703948
10.

Understanding the genetic control and physiological traits associated with rhizosheath production by barley (Hordeum vulgare).

George TS, Brown LK, Ramsay L, White PJ, Newton AC, Bengough AG, Russell J, Thomas WT.

New Phytol. 2014 Jul;203(1):195-205. doi: 10.1111/nph.12786. Epub 2014 Mar 28.

PMID:
24684319
11.

Intramolecular conformational changes optimize protein kinase C signaling.

Antal CE, Violin JD, Kunkel MT, Skovsø S, Newton AC.

Chem Biol. 2014 Apr 24;21(4):459-69. doi: 10.1016/j.chembiol.2014.02.008. Epub 2014 Mar 13.

PMID:
24631122
12.

Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation.

Cone AC, Cavin G, Ambrosi C, Hakozaki H, Wu-Zhang AX, Kunkel MT, Newton AC, Sosinsky GE.

J Biol Chem. 2014 Mar 28;289(13):8781-98. doi: 10.1074/jbc.M113.533265. Epub 2014 Feb 5.

13.

Turning off AKT: PHLPP as a drug target.

Newton AC, Trotman LC.

Annu Rev Pharmacol Toxicol. 2014;54:537-58. doi: 10.1146/annurev-pharmtox-011112-140338. Review.

14.

Carbon pools recover more quickly than plant biodiversity in tropical secondary forests.

Martin PA, Newton AC, Bullock JM.

Proc Biol Sci. 2013 Nov 6;280(1773):20132236. doi: 10.1098/rspb.2013.2236. Print 2013 Dec 22. Erratum in: Proc Biol Sci. 2014 May 7;281(1782):20140303.

15.

Imaging kinase activity at protein scaffolds.

Kunkel MT, Newton AC.

Methods Mol Biol. 2014;1071:129-37. doi: 10.1007/978-1-62703-622-1_10.

16.

Spatiotemporal dynamics of phosphorylation in lipid second messenger signaling.

Antal CE, Newton AC.

Mol Cell Proteomics. 2013 Dec;12(12):3498-508. doi: 10.1074/mcp.R113.029819. Epub 2013 Jun 20. Review.

17.

Protein kinase C pharmacology: refining the toolbox.

Wu-Zhang AX, Newton AC.

Biochem J. 2013 Jun 1;452(2):195-209. doi: 10.1042/BJ20130220. Review.

18.

Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.

Scott AM, Antal CE, Newton AC.

J Biol Chem. 2013 Jun 7;288(23):16905-15. doi: 10.1074/jbc.M113.467456. Epub 2013 Apr 15.

19.

Ultrafast dynamics in iron tetracarbonyl olefin complexes investigated with two-dimensional vibrational spectroscopy.

Panman MR, Newton AC, Vos J, van den Bosch B, Bocokić V, Reek JN, Woutersen S.

Phys Chem Chem Phys. 2013 Jan 28;15(4):1115-22. doi: 10.1039/c2cp43565a.

PMID:
23223560
20.

Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging.

Wu-Zhang AX, Murphy AN, Bachman M, Newton AC.

J Biol Chem. 2012 Nov 2;287(45):37891-906. doi: 10.1074/jbc.M112.412635. Epub 2012 Sep 17.

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