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Results: 1 to 20 of 249

1.

Avidity-dependent programming of autoreactive T cells in T1D.

Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT.

PLoS One. 2014 May 20;9(5):e98074. doi: 10.1371/journal.pone.0098074. eCollection 2014.

PMID:
24844227
[PubMed - in process]
Free PMC Article
2.

Restoring the balance: immunotherapeutic combinations for autoimmune disease.

Smilek DE, Ehlers MR, Nepom GT.

Dis Model Mech. 2014 May;7(5):503-13. doi: 10.1242/dmm.015099.

PMID:
24795433
[PubMed - in process]
Free PMC Article
3.

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.

Rigby MR, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR; T1DAL Study Team.

Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23.

PMID:
24622414
[PubMed - in process]
4.

Low HERV-K(C4) copy number is associated with type 1 diabetes.

Mason MJ, Speake C, Gersuk VH, Nguyen QA, O'Brien KK, Odegard JM, Buckner JH, Greenbaum CJ, Chaussabel D, Nepom GT.

Diabetes. 2014 May;63(5):1789-95. doi: 10.2337/db13-1382. Epub 2014 Jan 15.

PMID:
24430436
[PubMed - indexed for MEDLINE]
5.

Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope.

Dahan R, Gebe JA, Preisinger A, James EA, Tendler M, Nepom GT, Reiter Y.

J Autoimmun. 2013 Dec;47:83-93. doi: 10.1016/j.jaut.2013.08.009. Epub 2013 Oct 3.

PMID:
24090977
[PubMed - in process]
6.

IL-10 induction from implants delivering pancreatic islets and hyaluronan.

Bollyky PL, Vernon RB, Falk BA, Preisinger A, Gooden MD, Nepom GT, Gebe JA.

J Diabetes Res. 2013;2013:342479. doi: 10.1155/2013/342479. Epub 2013 Jul 22.

PMID:
23971054
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.

Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D.

Immunity. 2013 Apr 18;38(4):831-44. doi: 10.1016/j.immuni.2012.12.008.

PMID:
23601689
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Anti-cytokine therapies in T1D: Concepts and strategies.

Nepom GT, Ehlers M, Mandrup-Poulsen T.

Clin Immunol. 2013 Dec;149(3):279-85. doi: 10.1016/j.clim.2013.02.003. Epub 2013 Feb 14. Review.

PMID:
23510726
[PubMed - indexed for MEDLINE]
9.

Reversal of diabetes in mice with a bioengineered islet implant incorporating a type I collagen hydrogel and sustained release of vascular endothelial growth factor.

Vernon RB, Preisinger A, Gooden MD, D'Amico LA, Yue BB, Bollyky PL, Kuhr CS, Hefty TR, Nepom GT, Gebe JA.

Cell Transplant. 2012;21(10):2099-110. doi: 10.3727/096368912X636786.

PMID:
23231959
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A functional framework for interpretation of genetic associations in T1D.

Nepom GT, Buckner JH.

Curr Opin Immunol. 2012 Oct;24(5):516-21. doi: 10.1016/j.coi.2012.07.003. Epub 2012 Jul 26. Review.

PMID:
22841349
[PubMed - indexed for MEDLINE]
11.

T cell autoreactivity in the transplant milieu.

Matthis J, Nepom GT.

Am J Transplant. 2012 Jul;12(7):1674-81. doi: 10.1111/j.1600-6143.2012.04109.x. Epub 2012 May 29. Review.

PMID:
22642536
[PubMed - indexed for MEDLINE]
Free Article
12.

MHC class II tetramers.

Nepom GT.

J Immunol. 2012 Mar 15;188(6):2477-82. doi: 10.4049/jimmunol.1102398. Review.

PMID:
22389204
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Self-reactive human CD4 T cell clones form unusual immunological synapses.

Schubert DA, Gordo S, Sabatino JJ Jr, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW.

J Exp Med. 2012 Feb 13;209(2):335-52. doi: 10.1084/jem.20111485. Epub 2012 Feb 6.

PMID:
22312112
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Immune-directed therapy for type 1 diabetes at the clinical level: the Immune Tolerance Network (ITN) experience.

Ehlers MR, Nepom GT.

Rev Diabet Stud. 2012 Winter;9(4):359-71. doi: 10.1900/RDS.2012.9.359. Epub 2012 Dec 28. Review.

PMID:
23804273
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration.

Evanko SP, Potter-Perigo S, Bollyky PL, Nepom GT, Wight TN.

Matrix Biol. 2012 Mar;31(2):90-100. doi: 10.1016/j.matbio.2011.10.004. Epub 2011 Nov 20.

PMID:
22155153
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.

Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA.

J Immunol. 2011 Jul 15;187(2):1039-46. doi: 10.4049/jimmunol.1001543. Epub 2011 Jun 8.

PMID:
21653833
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction.

Khadra A, Pietropaolo M, Nepom GT, Sherman A.

PLoS One. 2011 May 10;6(5):e14796. doi: 10.1371/journal.pone.0014796.

PMID:
21573001
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.

Bollyky PL, Wu RP, Falk BA, Lord JD, Long SA, Preisinger A, Teng B, Holt GE, Standifer NE, Braun KR, Xie CF, Samuels PL, Vernon RB, Gebe JA, Wight TN, Nepom GT.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7938-43. doi: 10.1073/pnas.1017360108. Epub 2011 Apr 25.

PMID:
21518860
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Challenges in the pursuit of immune tolerance.

Nepom GT, St Clair EW, Turka LA.

Immunol Rev. 2011 May;241(1):49-62. doi: 10.1111/j.1600-065X.2011.01003.x. Review.

PMID:
21488889
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Common variants in P2RY11 are associated with narcolepsy.

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Högl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E.

Nat Genet. 2011 Jan;43(1):66-71. doi: 10.1038/ng.734. Epub 2010 Dec 19. Erratum in: Nat Genet. 2011 Oct;43(10):1040.

PMID:
21170044
[PubMed - indexed for MEDLINE]
Free PMC Article

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