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Results: 1 to 20 of 130


Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors.

Gupta J, Igea A, Papaioannou M, Lopez-Casas PP, Llonch E, Hidalgo M, Gorgoulis VG, Nebreda AR.

Oncotarget. 2015 Apr 14. [Epub ahead of print]


Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.

Gupta J, Nebreda AR.

FEBS J. 2015 Feb 27. doi: 10.1111/febs.13250. [Epub ahead of print]


Oxidative Stress Is a Central Target for Physical Exercise Neuroprotection Against Pathological Brain Aging.

García-Mesa Y, Colie S, Corpas R, Cristòfol R, Comellas F, Nebreda AR, Giménez-Llort L, Sanfeliu C.

J Gerontol A Biol Sci Med Sci. 2015 Feb 26. pii: glv005. [Epub ahead of print]


MAPK signaling control of colon cancer metastasis.

Urosevic J, Nebreda AR, Gomis RR.

Cell Cycle. 2014;13(17):2641-2. doi: 10.4161/15384101.2014.946374. No abstract available.


Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR, Gomis RR.

Nat Cell Biol. 2014 Jul;16(7):685-94. doi: 10.1038/ncb2977. Epub 2014 Jun 1.


Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival.

Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG, Nebreda AR.

Cancer Cell. 2014 Apr 14;25(4):484-500. doi: 10.1016/j.ccr.2014.02.019. Epub 2014 Mar 27.


Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.

Pereira L, Igea A, Canovas B, Dolado I, Nebreda AR.

EMBO Mol Med. 2013 Nov;5(11):1759-74. doi: 10.1002/emmm.201302732. Epub 2013 Sep 24.


p38 MAPK: a dual role in hepatocyte proliferation through reactive oxygen species.

Tormos AM, Taléns-Visconti R, Nebreda AR, Sastre J.

Free Radic Res. 2013 Nov;47(11):905-16. doi: 10.3109/10715762.2013.821200. Epub 2013 Oct 4. Review.


Multi-phosphorylation of the intrinsically disordered unique domain of c-Src studied by in-cell and real-time NMR spectroscopy.

Amata I, Maffei M, Igea A, Gay M, Vilaseca M, Nebreda AR, Pons M.

Chembiochem. 2013 Sep 23;14(14):1820-7. doi: 10.1002/cbic.201300139. Epub 2013 Jun 6.


Lipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism.

Pérez Y, Maffei M, Igea A, Amata I, Gairí M, Nebreda AR, Bernadó P, Pons M.

Sci Rep. 2013;3:1295. doi: 10.1038/srep01295.


SnapShot: p38 MAPK substrates.

Trempolec N, Dave-Coll N, Nebreda AR.

Cell. 2013 Feb 14;152(4):924-924.e1. doi: 10.1016/j.cell.2013.01.047. No abstract available.


SnapShot: p38 MAPK signaling.

Trempolec N, Dave-Coll N, Nebreda AR.

Cell. 2013 Jan 31;152(3):656-656.e1. doi: 10.1016/j.cell.2013.01.029. No abstract available.


Liver-specific p38α deficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice.

Tormos AM, Arduini A, Talens-Visconti R, del Barco Barrantes I, Nebreda AR, Sastre J.

Hepatology. 2013 May;57(5):1950-61. doi: 10.1002/hep.26174. Epub 2013 Jan 25.


Gadd45γ and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression.

Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A.

Dev Cell. 2012 Nov 13;23(5):1020-31. doi: 10.1016/j.devcel.2012.09.016. Epub 2012 Oct 25.


The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest.

Llopis A, Salvador N, Ercilla A, Guaita-Esteruelas S, Barrantes Idel B, Gupta J, Gaestel M, Davis RJ, Nebreda AR, Agell N.

Cell Cycle. 2012 Oct 1;11(19):3627-37. doi: 10.4161/cc.21917. Epub 2012 Aug 30.


Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.

Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, Del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barilà D, Maina F.

J Hepatol. 2012 Dec;57(6):1292-8. doi: 10.1016/j.jhep.2012.07.044. Epub 2012 Aug 10.


p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals.

Hu P, Nebreda AR, Liu Y, Carlesso N, Kaplan M, Kapur R.

J Biol Chem. 2012 Sep 28;287(40):33215-26. Epub 2012 Aug 2.


The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress.

Joaquin M, Gubern A, González-Nuñez D, Josué Ruiz E, Ferreiro I, de Nadal E, Nebreda AR, Posas F.

EMBO J. 2012 Jun 29;31(13):2952-64. doi: 10.1038/emboj.2012.122. Epub 2012 May 8.


Genetic evidence for critical roles of P38α protein in regulating mast cell differentiation and chemotaxis through distinct mechanisms.

Hu P, Carlesso N, Xu M, Liu Y, Nebreda AR, Takemoto C, Kapur R.

J Biol Chem. 2012 Jun 8;287(24):20258-69. doi: 10.1074/jbc.M112.358119. Epub 2012 Apr 19.


Roles of p38 MAPKs in invasion and metastasis.

del Barco Barrantes I, Nebreda AR.

Biochem Soc Trans. 2012 Feb;40(1):79-84. doi: 10.1042/BST20110676. Review.

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