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Nattokinase prevents beta-amyloid peptide (Abeta(1-42)) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption in mice.
Naik S, Katariya R, Shelke S, Patravale V, Umekar M, Kotagale N, Taksande B. Naik S, et al. Eur J Pharmacol. 2023 Aug 5;952:175821. doi: 10.1016/j.ejphar.2023.175821. Epub 2023 May 30. Eur J Pharmacol. 2023. PMID: 37263404
Although AD is typically considered a cognitive neurodegenerative disorder, almost all people diagnosed with AD develop neuropsychiatric complications at some stage in their life span. The present study investigated the effect of chronic Nattokinase (NK) administration on …
Although AD is typically considered a cognitive neurodegenerative disorder, almost all people diagnosed with AD develop neuropsychiatric com …
A pilot study on the serum pharmacokinetics of nattokinase in humans following a single, oral, daily dose.
Ero MP, Ng CM, Mihailovski T, Harvey NR, Lewis BH. Ero MP, et al. Altern Ther Health Med. 2013 May-Jun;19(3):16-9. Altern Ther Health Med. 2013. PMID: 23709455
Little is known regarding the pharmacokinetic and pharmacodynamic properties of this enzyme, and the bioavailability of nattokinase is currently unknown. OBJECTIVE: This study intended to (1) detect nattokinase directly and immunologically, (2) show that nattokin …
Little is known regarding the pharmacokinetic and pharmacodynamic properties of this enzyme, and the bioavailability of nattokinase i …
Directed evolution improves the fibrinolytic activity of nattokinase from Bacillus natto.
Yongjun C, Wei B, Shujun J, Meizhi W, Yan J, Yan Y, Zhongliang Z, Goulin Z. Yongjun C, et al. FEMS Microbiol Lett. 2011 Dec;325(2):155-61. doi: 10.1111/j.1574-6968.2011.02423.x. FEMS Microbiol Lett. 2011. PMID: 22029857
Nattokinase (subtilisin NAT, NK) is a relatively effective microbial fibrinolytic enzyme that has been identified and characterized from Bacillus natto. ...The current study shows that the evolution of nattokinase with improved fibrinolytic activity by DNA family sh …
Nattokinase (subtilisin NAT, NK) is a relatively effective microbial fibrinolytic enzyme that has been identified and characterized f …
Hyaluronic acid-fibrin interpenetrating double network hydrogel prepared in situ by orthogonal disulfide cross-linking reaction for biomedical applications.
Zhang Y, Heher P, Hilborn J, Redl H, Ossipov DA. Zhang Y, et al. Acta Biomater. 2016 Jul 1;38:23-32. doi: 10.1016/j.actbio.2016.04.041. Epub 2016 Apr 28. Acta Biomater. 2016. PMID: 27134013
Combining thiol-derivatized HA with thrombin and 2-dithiopyridyl-modified HA with fibrinogen and then mixing the obtained liquid formulations afforded IPNs with fibrin-resembling fibrillar architectures at different ratios between fibrin and HA networks. The formation of two netw …
Combining thiol-derivatized HA with thrombin and 2-dithiopyridyl-modified HA with fibrinogen and then mixing the obtained liquid formulation …