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Arch Otolaryngol Head Neck Surg. 2002 Oct;128(10):1196-7.

Nasopharyngectomy after failure of 2 courses of radiation therapy.

Author information

  • 1Department of Otolaryngology & Bronchoesophagology, Rush-Presbyterian-Sain Luke's Medical Center, Chicago, IL 60602, USA. ibrahimhani@hotmail.com

Abstract

BACKGROUND:

Recurrence of nasopharyngeal carcinoma after initial therapy has been reported to range between 18% and 54%. As an alternative to surgical salvage, patients with recurrent nasopharyngeal carcinoma are offered a second course of radiation therapy. If this second course fails, patients may be candidates for surgical resection.

OBJECTIVE:

To identify the effectiveness and morbidity of surgical resection of recurrent nasopharyngeal carcinoma in patients who have received 2 cycles of external beam radiation.

DESIGN AND SETTING:

Retrospective survey of 6 patients in a university-based practice who underwent resection of recurrent nasopharyngeal carcinoma after 2 courses of radiation therapy.

PATIENTS:

Our study group comprised 4 women and 2 men aged between 35 and 67 years. All patients underwent 2 courses of radiation with a mean total dose of 11 500 rad (115 Gy) (range, 9500-13 200 rad [95-132 Gy]) delivered to the nasopharynx prior to resection. The mean duration between the second course of radiation and resection is 21 months (range, 8-52 months). The mean follow-up period is 7.2 years (range, 4.2-11.5 years).

INTERVENTION:

Nasopharyngectomy after failure of 2 courses of radiation therapy.

MAIN OUTCOME MEASURES:

Postoperative clinical outcome and morbidity.

RESULTS:

Five years after resection, 1 patient died of disease. The remaining 5 patients (83%) are alive with no evidence of disease. Osteomyelitis is the most common complication, affecting 5 patients. Three of the 5 patients with osteomyelitis required operative debridement of the nasopharynx and split-thickness skin grafting. Other complications include oronasal fistula (2 patients), chronic otitis media (2 patients), and nasopharyngeal stenosis (1 patient).

CONCLUSION:

Although poor wound healing is evident, the overall 5-year survival of 83% is encouraging.

PMID:
12365893
[PubMed - indexed for MEDLINE]
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