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Results: 1 to 20 of 66

1.

Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).

Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T.

J Med Chem. 2015 Feb 26;58(4):1669-90. doi: 10.1021/jm501185j. Epub 2015 Feb 11.

PMID:
25671290
2.

Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model.

Nakauchi Y, Yamazaki S, Napier SC, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H.

Exp Hematol. 2015 Feb;43(2):79-88.e1-4. doi: 10.1016/j.exphem.2014.10.008. Epub 2014 Oct 30.

3.

Concordance between digital pathology and light microscopy in general surgical pathology: a pilot study of 100 cases.

Houghton JP, Ervine AJ, Kenny SL, Kelly PJ, Napier SS, McCluggage WG, Walsh MY, Hamilton PW.

J Clin Pathol. 2014 Dec;67(12):1052-5. doi: 10.1136/jclinpath-2014-202491. Epub 2014 Sep 23.

PMID:
25248822
4.

When should we not respect a patient's wish?

Napier S.

J Clin Ethics. 2014 Fall;25(3):196-206.

PMID:
25192344
5.

Visual impairment due to bilateral multifocal choroidal metastasis of parotid adenocarcinoma: a case report.

Walls G, Napier S, Stewart D.

Front Oncol. 2014 Jun 5;4:136. doi: 10.3389/fonc.2014.00136. eCollection 2014.

6.

Frequency of regulatory T-cell and hepatitis C viral antigen-specific immune response in recurrent hepatitis C after liver transplantation.

Utsumi M, Takaki A, Umeda Y, Koike K, Napier SC, Watanabe N, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Yasunaka T, Nakayama E, Yamamoto K, Fujiwara T, Yagi T.

Transpl Immunol. 2014 Jun;31(1):33-41. doi: 10.1016/j.trim.2014.05.006. Epub 2014 Jun 5.

PMID:
24907425
7.

Challenging research on human subjects: justice and uncompensated harms.

Napier S.

Theor Med Bioeth. 2013 Feb;34(1):29-51. doi: 10.1007/s11017-013-9241-9.

PMID:
23378154
8.

Persons and evidence for death: A reply to Bulzacchelli.

Napier S.

Linacre Q. 2013 Feb;80(1):56-62. doi: 10.1179/0024363912Z.0000000006.

PMID:
24845371
9.

Twinning, identity, and moral status.

Napier S.

Am J Bioeth. 2013;13(1):42-3. doi: 10.1080/15265161.2012.747029. No abstract available.

PMID:
23311844
10.

Checking pregnancy status in adolescent girls before procedures under general anaesthesia.

Donaldson JF, Napier SJ, Ward-Jones M, Wheeler RA, Spargo PM.

Arch Dis Child. 2012 Oct;97(10):895-9. doi: 10.1136/archdischild-2011-301229. Epub 2012 Mar 23.

PMID:
22447994
11.

The dead donor rule and means-end reasoning--a reply to Gardiner and Sparrow.

Napier S.

Camb Q Healthc Ethics. 2012 Jan;21(1):134-40. No abstract available.

PMID:
22256381
12.

Out of the frying pan and into the fire.

Napier S.

Am J Bioeth. 2011 Aug;11(8):60-1. doi: 10.1080/15265161.2011.583329. No abstract available.

PMID:
21806447
13.

Clinical medical sciences for undergraduate dental students in the United Kingdom and Ireland - a curriculum.

Mighell AJ, Atkin PA, Webster K, Thomas SJ, McCreary CE, Healy CM, Gibson J, Crighton AJ, Dawson LJ, Smalley JO, Allan RB, Oliver RJ, Pattrick MG, Pemberton MN, Theaker ED, Poate TW, Buchanan JA, Greenwood M, Bee D, Yates JM, Crean SJ, Napier SS.

Eur J Dent Educ. 2011 Aug;15(3):179-88. doi: 10.1111/j.1600-0579.2010.00654.x. Epub 2011 Mar 17.

PMID:
21762323
14.

Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V1A receptor antagonist.

Arbuckle W, Baker J, Barn D, Bingham M, Brown A, Buchanan K, Craighead M, Goodwin R, Goutcher S, Kiczun M, Lyons A, Milne R, Montgomery B, Napier S, Presland J, Sloan H, Turnbull Z, Wishart G.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4622-8. doi: 10.1016/j.bmcl.2011.05.092. Epub 2011 May 30.

PMID:
21700453
15.

Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists.

Baker J, Bingham M, Blackburn-Munro R, Cai J, Craighead M, Gilfillan R, Goan K, Jaap D, Milne R, Morphy JR, Napier S, Presland J, Spinks G, Thomson F.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3603-7. doi: 10.1016/j.bmcl.2011.04.104. Epub 2011 May 1.

PMID:
21601454
16.

Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan R, Craighead M, Desai H, Ho KK, MacSweeney C, Milne R, Richard Morphy J, Neagu I, Ohlmeyer MH, Pick J, Presland J, Riviello C, Zanetakos HA, Zhao J, Webb ML.

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3813-7. doi: 10.1016/j.bmcl.2011.04.022. Epub 2011 Apr 13.

PMID:
21596563
17.

The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Napier S, Wishart G, Arbuckle W, Baker J, Barn D, Bingham M, Brown A, Byford A, Claxton C, Craighead M, Buchanan K, Fielding L, Gibson L, Goodwin R, Goutcher S, Irving N, MacSweeney C, Milne R, Mort C, Presland J, Sloan H, Thomson F, Turnbull Z, Young T.

Bioorg Med Chem Lett. 2011 May 15;21(10):3163-7. doi: 10.1016/j.bmcl.2011.02.096. Epub 2011 Mar 4.

PMID:
21458261
18.

Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.

Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan JH, Craighead M, Desai H, Goan KA, Ho KK, Hulskotte EG, MacSweeney CP, Milne R, Morphy JR, Neagu I, Ohlmeyer MH, Peeters AW, Presland J, Riviello C, Ruigt GS, Thomson FJ, Zanetakos HA, Zhao J, Webb ML.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1871-5. doi: 10.1016/j.bmcl.2010.12.081. Epub 2010 Dec 21.

PMID:
21353540
19.

TBAF-catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds.

Louërat F, Tye H, Napier S, Garrigou M, Whittaker M, Gros PC.

Org Biomol Chem. 2011 Mar 21;9(6):1768-73. doi: 10.1039/c0ob00710b. Epub 2011 Jan 24.

PMID:
21264409
20.

The identification, and optimisation of hERG selectivity, of a mixed NET/SERT re-uptake inhibitor for the treatment of pain.

Angus D, Bingham M, Buchanan D, Dunbar N, Gibson L, Goodwin R, Haunsø A, Houghton A, Huggett M, Morphy R, Napier S, Nimz O, Passmore J, Walker G.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):271-5. doi: 10.1016/j.bmcl.2010.11.021. Epub 2010 Nov 6.

PMID:
21112782
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