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Risk for malignancy in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs compared to the general population: A nationwide cohort study in Japan.

Harigai M, Nanki T, Koike R, Tanaka M, Watanabe-Imai K, Komano Y, Sakai R, Yamazaki H, Koike T, Miyasaka N.

Mod Rheumatol. 2016 Mar 11:1-9. [Epub ahead of print]


High prevalence of cardiovascular comorbidities in patients with rheumatoid arthritis from a population-based cross-sectional study of a Japanese health insurance database.

Sakai R, Hirano F, Kihara M, Yokoyama W, Yamazaki H, Harada S, Nanki T, Koike R, Miyasaka N, Harigai M.

Mod Rheumatol. 2015 Dec 14:1-7. [Epub ahead of print]


Diagnostic performance of measuring antibodies to the glycopeptidolipid core antigen specific to Mycobacterium avium complex in patients with rheumatoid arthritis: results from a cross-sectional observational study.

Hirose W, Uchiyama T, Nemoto A, Harigai M, Itoh K, Ishizuka T, Matsumoto M, Yamaoka K, Nanki T.

Arthritis Res Ther. 2015 Sep 28;17:273. doi: 10.1186/s13075-015-0787-y.


Leucine-rich α2 -glycoprotein as a potential biomarker for joint inflammation during anti-interleukin-6 biologic therapy in rheumatoid arthritis.

Fujimoto M, Serada S, Suzuki K, Nishikawa A, Ogata A, Nanki T, Hattori K, Kohsaka H, Miyasaka N, Takeuchi T, Naka T.

Arthritis Rheumatol. 2015 May;67(8):2056-60. doi: 10.1002/art.39164.


Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry.

Sakai R, Cho SK, Nanki T, Watanabe K, Yamazaki H, Tanaka M, Koike R, Tanaka Y, Saito K, Hirata S, Amano K, Nagasawa H, Sumida T, Hayashi T, Sugihara T, Dobashi H, Yasuda S, Sawada T, Ezawa K, Ueda A, Fujii T, Migita K, Miyasaka N, Harigai M; REAL Study Group.

Arthritis Res Ther. 2015 Mar 23;17:74. doi: 10.1186/s13075-015-0583-8.


Assessment of risks of pulmonary infection during 12 months following immunosuppressive treatment for active connective tissue diseases: a large-scale prospective cohort study.

Yamazaki H, Sakai R, Koike R, Miyazaki Y, Tanaka M, Nanki T, Watanabe K, Yasuda S, Kurita T, Kaneko Y, Tanaka Y, Nishioka Y, Takasaki Y, Nagasaka K, Nagasawa H, Tohma S, Dohi M, Sugihara T, Sugiyama H, Kawaguchi Y, Inase N, Ochi S, Hagiyama H, Kohsaka H, Miyasaka N, Harigai M; PREVENT Study Group.

J Rheumatol. 2015 Apr;42(4):614-22. doi: 10.3899/jrheum.140778. Epub 2015 Feb 1.


Pulmonary infections following immunosuppressive treatments during hospitalization worsen the short-term vital prognosis for patients with connective tissue disease-associated interstitial pneumonia.

Tanaka M, Koike R, Sakai R, Saito K, Hirata S, Nagasawa H, Kameda H, Hara M, Kawaguchi Y, Tohma S, Takasaki Y, Dohi M, Nishioka Y, Yasuda S, Miyazaki Y, Kaneko Y, Nanki T, Watanabe K, Yamazaki H, Miyasaka N, Harigai M.

Mod Rheumatol. 2015 Jul;25(4):609-14. doi: 10.3109/14397595.2014.980384. Epub 2014 Dec 15.


Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade.

Miyabe Y, Miyabe C, Iwai Y, Yokoyama W, Sekine C, Sugimoto K, Harigai M, Miyasaka M, Miyasaka N, Nanki T.

Arthritis Res Ther. 2014 Oct 2;16(5):461. doi: 10.1186/s13075-014-0461-9.


Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice.

Yokoyama W, Kohsaka H, Kaneko K, Walters M, Takayasu A, Fukuda S, Miyabe C, Miyabe Y, Love PE, Nakamoto N, Kanai T, Watanabe-Imai K, Charvat TT, Penfold ME, Jaen J, Schall TJ, Harigai M, Miyasaka N, Nanki T.

Arthritis Res Ther. 2014 Sep 24;16(5):445. doi: 10.1186/s13075-014-0445-9.


Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis.

Fukuda S, Kohsaka H, Takayasu A, Yokoyama W, Miyabe C, Miyabe Y, Harigai M, Miyasaka N, Nanki T.

BMC Musculoskelet Disord. 2014 Aug 12;15:275. doi: 10.1186/1471-2474-15-275.


Could retinoids be a potential treatment for rheumatic diseases?

Miyabe Y, Miyabe C, Nanki T.

Rheumatol Int. 2015 Jan;35(1):35-41. doi: 10.1007/s00296-014-3067-2. Epub 2014 Jun 18. Review.


The risk of serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors decreased over time: a report from the registry of Japanese rheumatoid arthritis patients on biologics for long-term safety (REAL) database.

Sakai R, Cho SK, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Amano K, Tanaka Y, Sumida T, Ihata A, Yasuda S, Nakajima A, Sugihara T, Tamura N, Fujii T, Dobashi H, Miura Y, Miyasaka N, Harigai M; REAL study group.

Rheumatol Int. 2014 Dec;34(12):1729-36. doi: 10.1007/s00296-014-3045-8. Epub 2014 May 23.


Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg-Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG.

Umezawa N, Kohsaka H, Nanki T, Watanabe K, Tanaka M, Shane PY, Miyasaka N.

Mod Rheumatol. 2014 Jul;24(4):685-7. doi: 10.3109/14397595.2013.874734. Epub 2014 Feb 11.


Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses.

Fukuda S, Nanki T, Morio T, Hasegawa H, Koike R, Miyasaka N.

Mod Rheumatol. 2014 May;24(3):537-9. doi: 10.3109/14397595.2013.852853. Epub 2014 Feb 7.


Serodiagnosis of Mycobacterium avium complex pulmonary disease in rheumatoid arthritis.

Komazaki Y, Miyazaki Y, Fujie T, Sakashita H, Tsuchiya K, Tamaoka M, Sumi Y, Maruyama Y, Nanki T, Inase N.

Respiration. 2014;87(2):129-35. doi: 10.1159/000354791. Epub 2013 Dec 4.


A comparison of incidence and risk factors for serious adverse events in rheumatoid arthritis patients with etanercept or adalimumab in Korea and Japan.

Cho SK, Sakai R, Nanki T, Koike R, Watanabe K, Yamazaki H, Nagasawa H, Tanaka Y, Nakajima A, Yasuda S, Ihata A, Ezawa K, Won S, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Miyasaka N, Bae SC, Harigai M; RESEARCH investigators; REAL Study Group.

Mod Rheumatol. 2014 Jul;24(4):572-9. doi: 10.3109/14397595.2013.860695. Epub 2013 Dec 9.


CCL18 activates fibroblast-like synoviocytes in patients with rheumatoid arthritis.

Takayasu A, Miyabe Y, Yokoyama W, Kaneko K, Fukuda S, Miyasaka N, Miyabe C, Kubota T, Nanki T.

J Rheumatol. 2013 Jun;40(6):1026-8. doi: 10.3899/jrheum.121412. No abstract available.


Necessity of lysophosphatidic acid receptor 1 for development of arthritis.

Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, Ueda H, Miyasaka M, Miyasaka N, Nanki T.

Arthritis Rheum. 2013 Aug;65(8):2037-47. doi: 10.1002/art.37991.


Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections.

Nanki T, Onoue I, Nagasaka K, Takayasu A, Ebisawa M, Hosoya T, Shirai T, Sugihara T, Hirata S, Kubota T, Harigai M, Miyasaka N.

Ann Rheum Dis. 2013 Jun;72(6):1100-2. doi: 10.1136/annrheumdis-2012-202768. Epub 2013 Jan 24. No abstract available.

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