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The following terms were not found in PubMed: 4-bromo-2-fluoro-phenyl, quinoxaline-5-carboxamide
Unknown fields were ignored: [2,1-c]
Page 1
Catalyst-Controlled Divergent Cycloisomerizations of N-Propargyl Indoles.
Nie Y, Zhou J, Wang Y. Nie Y, et al. Org Lett. 2023 Jun 16;25(23):4350-4354. doi: 10.1021/acs.orglett.3c01488. Epub 2023 Jun 5. Org Lett. 2023. PMID: 37272670
Herein, a new series of catalyst-controlled divergent cycloisomerizations of indole-tethered alkynes was developed utilizing readily available, versatile, and flexible N-propargyl indoles as substrates and BrettPhosAuNTf(2) and PtCl(4) as catalysts, where the chemodivergen …
Herein, a new series of catalyst-controlled divergent cycloisomerizations of indole-tethered alkynes was developed utilizing readily availab …
Magnetic ordering in a vanadium-organic coordination polymer using a pyrrolo[2,3-d:5,4-d']bis(thiazole)-based ligand.
Getmanenko YA, Mullins CS, Nesterov VN, Lake S, Risko C, Johnston-Halperin E. Getmanenko YA, et al. RSC Adv. 2018 Oct 25;8(63):36223-36232. doi: 10.1039/c8ra05697h. eCollection 2018 Oct 22. RSC Adv. 2018. PMID: 35558484 Free PMC article.
This material was prepared using a new tetracyano-substituted quinoidal organic small molecule 7 based on a tricyclic heterocycle 4-hexyl-4H-pyrrolo[2,3-d:5,4-d']bis(thiazole) (C(6)-PBTz). Single crystal X-ray diffraction of the 2,6-diiodo derivative of the parent C …
This material was prepared using a new tetracyano-substituted quinoidal organic small molecule 7 based on a tricyclic heterocycle 4-hexyl- …
Phosphodiesterase 5 inhibitor mirodenafil ameliorates Alzheimer-like pathology and symptoms by multimodal actions.
Kang BW, Kim F, Cho JY, Kim S, Rhee J, Choung JJ. Kang BW, et al. Alzheimers Res Ther. 2022 Jul 8;14(1):92. doi: 10.1186/s13195-022-01034-3. Alzheimers Res Ther. 2022. PMID: 35804462 Free PMC article.
We evaluated a blood-brain barrier penetrating phosphodiesterase 5 (PDE5) inhibitor, mirodenafil (5-ethyl-2-7-n-propyl-3,5-dihydrro-4H-pyrrolo[3,2-d]pyrimidin-4-one), for its therapeutic effects on AD with polypharmacological properties. ...
We evaluated a blood-brain barrier penetrating phosphodiesterase 5 (PDE5) inhibitor, mirodenafil (5-ethyl-2-7-n-propyl-3,5-dihydrro- …
Gold-Catalyzed Intramolecular Hydroarylation and Transfer Hydrogenation of N-Aryl Propargylamines to Construct Tetrahydroquinolines and 5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolines.
Yi N, Liu Y, Xiong Y, Gong H, Tan JP, Fang Z, Yi B. Yi N, et al. J Org Chem. 2023 Aug 18;88(16):11945-11953. doi: 10.1021/acs.joc.3c01214. Epub 2023 Aug 10. J Org Chem. 2023. PMID: 37560821
A novel protocol of gold-catalyzed N-aryl propargylamines to construct tetrahydroquinolines and 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolines in moderate to good yields has been developed through the tandem reactions of intramolecular hydroarylation and transfer …
A novel protocol of gold-catalyzed N-aryl propargylamines to construct tetrahydroquinolines and 5,6-dihydro-4H-pyrrolo[ …
Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Gangjee A, Kurup S, Ihnat MA, Thorpe JE, Shenoy SS. Gangjee A, et al. Bioorg Med Chem. 2010 May 15;18(10):3575-87. doi: 10.1016/j.bmc.2010.03.052. Epub 2010 Mar 27. Bioorg Med Chem. 2010. PMID: 20403700 Free PMC article.
In addition, five N(4)-phenylsubstituted-6-phenylmethylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines 16-20 were synthesized to evaluate the importance of the 2-NH(2) moiety for multiple receptor tyrosine kinase (RTK) inhibition. Cyclocondensation of alpha-halomethylbenzy …
In addition, five N(4)-phenylsubstituted-6-phenylmethylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines 16-20 were synthesized to eval …
Pyrrolo[1,2-a][1,4]benzodiazepine: a novel class of non-azole anti-dermatophyte anti-fungal agents.
Meerpoel L, Van Gestel J, Van Gerven F, Woestenborghs F, Marichal P, Sipido V, Terence G, Nash R, Corens D, Richards RD. Meerpoel L, et al. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3453-8. doi: 10.1016/j.bmcl.2005.05.007. Bioorg Med Chem Lett. 2005. PMID: 15950472
The anti-fungal structure-activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is described together with its mode of action that appeared to be the inhibition of squalene epoxidase. ...
The anti-fungal structure-activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is de …
Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.
Tenora L, Galeta J, Řezníčková E, Kryštof V, Potáček M. Tenora L, et al. J Org Chem. 2016 Dec 2;81(23):11841-11856. doi: 10.1021/acs.joc.6b02230. Epub 2016 Nov 10. J Org Chem. 2016. PMID: 27934472
C-H activation of position 3 of a substituted pyrazole ring catalyzed by palladium(II) was straightforward and convenient for arylated or heteroarylated 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles. Moreover, we introduced simple protection of the nitrogen in …
C-H activation of position 3 of a substituted pyrazole ring catalyzed by palladium(II) was straightforward and convenient for arylated or he …
Hit-to-lead optimization of pyrrolo[1,2-a]quinoxalines as novel cannabinoid type 1 receptor antagonists.
Szabó G, Kiss R, Páyer-Lengyel D, Vukics K, Szikra J, Baki A, Molnár L, Fischer J, Keseru GM. Szabó G, et al. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3471-5. doi: 10.1016/j.bmcl.2009.05.010. Epub 2009 May 7. Bioorg Med Chem Lett. 2009. PMID: 19457667
Hit-to-lead optimization of a novel series of N-alkyl-N-[2-oxo-2-(4-aryl-4H-pyrrolo[1,2-a]quinoxaline-5-yl)-ethyl]-carboxylic acid amides, derived from a high throughput screening (HTS) hit, are described. ...
Hit-to-lead optimization of a novel series of N-alkyl-N-[2-oxo-2-(4-aryl-4H-pyrrolo[1,2-a]quinoxaline-5-yl)-ethy …
2,6-Dimethyl-9-methoxy-4H-pyrrolo[3,2,1-ij]quinolin-4-one, a new compound with unusual photosensitizing properties.
Baccichetti F, Carlassare F, Marzano C, Guiotto A, Rodighiero P, Chilin A, Bordin F. Baccichetti F, et al. J Photochem Photobiol B. 1994 Jul;24(2):101-8. doi: 10.1016/1011-1344(94)07011-3. J Photochem Photobiol B. 1994. PMID: 7931848
Some photobiological properties of 2,6-dimethyl-9-methoxy-4H-pyrrolo[3,2,1-ij]quinolin-4-one (PQ) have been studied in comparison with 8-methoxypsoralen (8-MOP). ...
Some photobiological properties of 2,6-dimethyl-9-methoxy-4H-pyrrolo[3,2,1-ij]quinolin-4-one (PQ) have been studied in compari …
An integrated computational approach to infer therapeutic targets from Campylobacter concisus and peptidomimetic based inhibition of its pyrimidine metabolism pathway.
Khan K, Jalal K, Alam Y, Alotaibi G, Al Mouslem A, Uddin R, Hassan SS, Basharat Z. Khan K, et al. J Biomol Struct Dyn. 2023;41(22):13127-13137. doi: 10.1080/07391102.2023.2191148. Epub 2023 Mar 31. J Biomol Struct Dyn. 2023. PMID: 37000926
Therefore, we identified 18 cytoplasmic potential therapeutic candidates against the type strain of C. concisus and deoxycytidine triphosphate deaminase (dCTP deaminase), involved in pyrimidine synthesis was selected for screening of peptidomimetic inhibitors (n > 30,00 …
Therefore, we identified 18 cytoplasmic potential therapeutic candidates against the type strain of C. concisus and deoxycytidine triphospha …
30 results