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Results: 1 to 20 of 150

1.

Tb927.10.6900 encodes the glucosyltransferase involved in synthesis of base J in Trypanosoma brucei.

Sekar A, Merritt C, Baugh L, Stuart K, Myler PJ.

Mol Biochem Parasitol. 2014 Jul 23. pii: S0166-6851(14)00083-8. doi: 10.1016/j.molbiopara.2014.07.005. [Epub ahead of print]

PMID:
25064607
[PubMed - as supplied by publisher]
2.

Structure of tyrosine aminotransferase from Leishmania infantum.

Moreno MA, Abramov A, Abendroth J, Alonso A, Zhang S, Alcolea PJ, Edwards T, Lorimer D, Myler PJ, Larraga V.

Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):583-7. doi: 10.1107/S2053230X14007845. Epub 2014 Apr 25.

PMID:
24817714
[PubMed - in process]
Free PMC Article
3.

Regulation dynamics of leishmania differentiation: deconvoluting signals and identifying phosphorylation trends.

Tsigankov P, Gherardini PF, Helmer-Citterich M, Sp├Ąth GF, Myler PJ, Zilberstein D.

Mol Cell Proteomics. 2014 Jul;13(7):1787-99. doi: 10.1074/mcp.M114.037705. Epub 2014 Apr 16.

PMID:
24741111
[PubMed - in process]
4.

Structure of the Reston ebolavirus VP30 C-terminal domain.

Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi: 10.1107/S2053230X14003811. Epub 2014 Mar 25.

PMID:
24699737
[PubMed - in process]
Free PMC Article
5.

Selecting targets from eukaryotic parasites for structural genomics and drug discovery.

Phan IQ, Stacy R, Myler PJ.

Methods Mol Biol. 2014;1140:53-9. doi: 10.1007/978-1-4939-0354-2_4.

PMID:
24590708
[PubMed - in process]
6.

Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani.

Martin JL, Yates PA, Soysa R, Alfaro JF, Yang F, Burnum-Johnson KE, Petyuk VA, Weitz KK, Camp DG 2nd, Smith RD, Wilmarth PA, David LL, Ramasamy G, Myler PJ, Carter NS.

PLoS Pathog. 2014 Feb 27;10(2):e1003938. doi: 10.1371/journal.ppat.1003938. eCollection 2014 Feb.

PMID:
24586154
[PubMed - in process]
Free PMC Article
7.

Crystal structure and putative substrate identification for the Entamoeba histolytica low molecular weight tyrosine phosphatase.

Linford AS, Jiang NM, Edwards TE, Sherman NE, Van Voorhis WC, Stewart LJ, Myler PJ, Staker BL, Petri WA Jr.

Mol Biochem Parasitol. 2014 Jan;193(1):33-44. doi: 10.1016/j.molbiopara.2014.01.003. Epub 2014 Feb 15.

PMID:
24548880
[PubMed - in process]
8.

Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity.

Wangtrakuldee P, Byrd MS, Campos CG, Henderson MW, Zhang Z, Clare M, Masoudi A, Myler PJ, Horn JR, Cotter PA, Hagen TJ.

ACS Med Chem Lett. 2013 Jul 1;4(8). doi: 10.1021/ml400034m.

PMID:
24376907
[PubMed]
Free PMC Article
9.

A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.

Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD.

Antimicrob Agents Chemother. 2014 Mar;58(3):1458-67. doi: 10.1128/AAC.01875-13. Epub 2013 Dec 23.

PMID:
24366729
[PubMed - in process]
10.

Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution.

Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C.

J Biol Chem. 2014 Jan 24;289(4):2139-47. doi: 10.1074/jbc.M113.525683. Epub 2013 Dec 4.

PMID:
24311791
[PubMed - indexed for MEDLINE]
11.

Solution structure of a putative FKBP-type peptidyl-propyl cis-trans isomerase from Giardia lamblia.

Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ.

J Biomol NMR. 2013 Dec;57(4):369-74. doi: 10.1007/s10858-013-9797-8. Epub 2013 Nov 29. No abstract available.

PMID:
24293257
[PubMed - indexed for MEDLINE]
12.

Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei.

Zhang Z, Jakkaraju S, Blain J, Gogol K, Zhao L, Hartley RC, Karlsson CA, Staker BL, Edwards TE, Stewart LJ, Myler PJ, Clare M, Begley DW, Horn JR, Hagen TJ.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6860-3. doi: 10.1016/j.bmcl.2013.09.101. Epub 2013 Oct 8.

PMID:
24157367
[PubMed - indexed for MEDLINE]
13.

Kinetoplastid-specific histone variant functions are conserved in Leishmania major.

Anderson BA, Wong IL, Baugh L, Ramasamy G, Myler PJ, Beverley SM.

Mol Biochem Parasitol. 2013 Oct;191(2):53-7. doi: 10.1016/j.molbiopara.2013.09.005. Epub 2013 Sep 27.

PMID:
24080031
[PubMed - indexed for MEDLINE]
14.

Crystal structure of a macrophage migration inhibitory factor from Giardia lamblia.

Buchko GW, Abendroth J, Robinson H, Zhang Y, Hewitt SN, Edwards TE, Van Voorhis WC, Myler PJ.

J Struct Funct Genomics. 2013 Jun;14(2):47-57. doi: 10.1007/s10969-013-9155-9. Epub 2013 May 25.

PMID:
23709284
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Combining functional and structural genomics to sample the essential Burkholderia structome.

Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D 3rd, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC.

PLoS One. 2013;8(1):e53851. doi: 10.1371/journal.pone.0053851. Epub 2013 Jan 31.

PMID:
23382856
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels.

Mittra B, Cortez M, Haydock A, Ramasamy G, Myler PJ, Andrews NW.

J Exp Med. 2013 Feb 11;210(2):401-16. doi: 10.1084/jem.20121368. Epub 2013 Feb 4.

PMID:
23382545
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A new drug for an old bug.

Myler PJ, Stacy R.

Chem Biol. 2012 Dec 21;19(12):1499-500. doi: 10.1016/j.chembiol.2012.12.003.

PMID:
23261593
[PubMed]
Free PMC Article
18.

Learning virulent proteins from integrated query networks.

Cadag E, Tarczy-Hornoch P, Myler PJ.

BMC Bioinformatics. 2012 Dec 2;13:321. doi: 10.1186/1471-2105-13-321.

PMID:
23198735
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, Velds A, Kerkhoven RM, Nieuwland M, Haydock A, Ramasamy G, Vainio S, Heidebrecht T, Perrakis A, Pagie L, van Steensel B, Myler PJ, Borst P.

Cell. 2012 Aug 31;150(5):909-21. doi: 10.1016/j.cell.2012.07.030.

PMID:
22939620
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium tuberculosis proteins.

Edwards TE, Liao R, Phan I, Myler PJ, Grundner C.

Protein Sci. 2012 Jul;21(7):1093-6. doi: 10.1002/pro.2084. Epub 2012 May 24.

PMID:
22544630
[PubMed - indexed for MEDLINE]
Free PMC Article

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