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Items: 1 to 20 of 175

1.

Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 Å resolution.

Naqvi KF, Staker BL, Dobson RC, Serbzhinskiy D, Sankaran B, Myler PJ, Hudson AO.

Acta Crystallogr F Struct Biol Commun. 2016 Jan 1;72(Pt 1):2-9. doi: 10.1107/S2053230X15023213. Epub 2016 Jan 1.

PMID:
26750477
2.

Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems.

Gillespie JJ, Phan IQ, Scheib H, Subramanian S, Edwards TE, Lehman SS, Piitulainen H, Rahman MS, Rennoll-Bankert KE, Staker BL, Taira S, Stacy R, Myler PJ, Azad AF, Pulliainen AT.

MBio. 2015 Dec 8;6(6):e01867-15. doi: 10.1128/mBio.01867-15.

3.

Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.

Goshu GM, Ghose D, Bain JM, Pierce PG, Begley DW, Hewitt SN, Udell HS, Myler PJ, Meganathan R, Hagen TJ.

Bioorg Med Chem Lett. 2015 Oct 31. pii: S0960-894X(15)30206-7. doi: 10.1016/j.bmcl.2015.10.096. [Epub ahead of print]

PMID:
26584881
4.

Size does matter: 18 amino acids at the N-terminal tip of an amino acid transporter in Leishmania determine substrate specificity.

Schlisselberg D, Mazarib E, Inbar E, Rentsch D, Myler PJ, Zilberstein D.

Sci Rep. 2015 Nov 9;5:16289. doi: 10.1038/srep16289.

5.

Recent contributions of structure-based drug design to the development of antibacterial compounds.

Staker BL, Buchko GW, Myler PJ.

Curr Opin Microbiol. 2015 Oct;27:133-8. doi: 10.1016/j.mib.2015.09.003. Review.

PMID:
26458180
6.

Advancing Trypanosoma brucei genome annotation through ribosome profiling and spliced leader mapping.

Parsons M, Ramasamy G, Vasconcelos EJ, Jensen BC, Myler PJ.

Mol Biochem Parasitol. 2015 Aug;202(2):1-10. doi: 10.1016/j.molbiopara.2015.09.002. Epub 2015 Sep 21.

PMID:
26393539
7.

Structural Genomics Support for Infectious Disease Drug Design.

Stacy R, Anderson WF, Myler PJ.

ACS Infect Dis. 2015 Mar 13;1(3):127-129. Epub 2015 Jan 20. No abstract available.

8.

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.

Phan IQ, Davies DR, Moretti NS, Shanmugam D, Cestari I, Anupama A, Fairman JW, Edwards TE, Stuart K, Schenkman S, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):615-21. doi: 10.1107/S2053230X15004185. Epub 2015 May 7.

PMID:
25961325
9.

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.

Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S167-71. doi: 10.1093/infdis/jiv090. Epub 2015 May 9.

PMID:
25957961
10.

Backbone chemical shift assignments for the sensor domain of the Burkholderia pseudomallei histidine kinase RisS: "missing" resonances at the dimer interface.

Buchko GW, Edwards TE, Hewitt SN, Phan IQ, Van Voorhis WC, Miller SI, Myler PJ.

Biomol NMR Assign. 2015 Oct;9(2):381-5. doi: 10.1007/s12104-015-9614-2. Epub 2015 May 9.

PMID:
25957069
11.

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.

Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi: 10.1107/S2053230X15006883. Epub 2015 Apr 21.

PMID:
25945716
12.

Structure of an ADP-ribosylation factor, ARF1, from Entamoeba histolytica bound to Mg(2+)-GDP.

Serbzhinskiy DA, Clifton MC, Sankaran B, Staker BL, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):594-9. doi: 10.1107/S2053230X15004677. Epub 2015 Apr 21.

PMID:
25945714
13.

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.

Lorimer DD, Choi R, Abramov A, Nakazawa Hewitt S, Gardberg AS, Van Voorhis WC, Staker BL, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):572-6. doi: 10.1107/S2053230X1500237X. Epub 2015 Apr 21.

PMID:
25945711
14.

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.

Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):560-5. doi: 10.1107/S2053230X1500179X. Epub 2015 Apr 21.

PMID:
25945709
15.

Structure of a CutA1 divalent-cation tolerance protein from Cryptosporidium parvum, the protozoal parasite responsible for cryptosporidiosis.

Buchko GW, Abendroth J, Clifton MC, Robinson H, Zhang Y, Hewitt SN, Staker BL, Edwards TE, Van Voorhis WC, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):522-30. doi: 10.1107/S2053230X14028210. Epub 2015 Apr 18.

PMID:
25945704
16.

Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.

Buchko GW, Yee A, Semesi A, Myler PJ, Arrowsmith CH, Hui R.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):514-21. doi: 10.1107/S2053230X1402799X. Epub 2015 Apr 18.

PMID:
25945703
17.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.

Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.

J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi: 10.1007/s10969-015-9197-2. Epub 2015 Apr 2.

PMID:
25832174
18.

Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.

Lambertz U, Oviedo Ovando ME, Vasconcelos EJ, Unrau PJ, Myler PJ, Reiner NE.

BMC Genomics. 2015 Mar 5;16:151. doi: 10.1186/s12864-015-1260-7.

19.

Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing.

Genest PA, Baugh L, Taipale A, Zhao W, Jan S, van Luenen HG, Korlach J, Clark T, Luong K, Boitano M, Turner S, Myler PJ, Borst P.

Nucleic Acids Res. 2015 Feb 27;43(4):2102-15. doi: 10.1093/nar/gkv095. Epub 2015 Feb 6.

20.

Increasing the structural coverage of tuberculosis drug targets.

Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ.

Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003. Epub 2014 Dec 19.

PMID:
25613812
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