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Results: 1 to 20 of 173

1.

DOT1L Inhibitor EPZ-5676 Displays Synergistic Antiproliferative Activity in Combination with Standard of Care Drugs and Hypomethylating Agents in MLL-Rearranged Leukemia Cells.

Klaus CR, Iwanowicz D, Johnston LD, Campbell CA, Smith JJ, Moyer MP, Copeland RA, Olhava EJ, Porter Scott M, Pollock RM, Daigle SR, Raimondi A.

J Pharmacol Exp Ther. 2014 Jul 3. pii: jpet.114.214577. [Epub ahead of print]

PMID:
24993360
[PubMed - as supplied by publisher]
Free Article
2.

DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism.

Skender B, Hofmanová J, Slavík J, Jelínková I, Machala M, Moyer MP, Kozubík A, Hyršlová Vaculová A.

Biochim Biophys Acta. 2014 Jun 19;1841(9):1308-1317. doi: 10.1016/j.bbalip.2014.06.005. [Epub ahead of print]

PMID:
24953781
[PubMed - as supplied by publisher]
3.

Integrated Chemical and Toxicological Investigation of UV-Chlorine/Chloramine Drinking Water Treatment.

Lyon BA, Milsk RY, DeAngelo AB, Simmons JE, Moyer MP, Weinberg HS.

Environ Sci Technol. 2014 Jun 17;48(12):6743-53. doi: 10.1021/es501412n. Epub 2014 Jun 4.

PMID:
24840005
[PubMed - in process]
4.

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.

Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.

Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.

PMID:
24735923
[PubMed - in process]
Free PMC Article
5.

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Li N, Lee K, Xi Y, Zhu B, Gary BD, Ramírez-Alcántara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP, Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA.

Oncogene. 2014 Apr 7. doi: 10.1038/onc.2014.94. [Epub ahead of print]

PMID:
24704829
[PubMed - as supplied by publisher]
6.

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma.

Knutson SK, Kawano S, Minoshima Y, Warholic NM, Huang KC, Xiao Y, Kadowaki T, Uesugi M, Kuznetsov G, Kumar N, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Waters NJ, Smith JJ, Porter-Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Uenaka T, Pollock RM, Kuntz KW, Yokoi A, Keilhack H.

Mol Cancer Ther. 2014 Apr;13(4):842-54. doi: 10.1158/1535-7163.MCT-13-0773. Epub 2014 Feb 21.

PMID:
24563539
[PubMed - in process]
7.

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.

Gonçalves V, Henriques A, Pereira J, Neves Costa A, Moyer MP, Moita LF, Gama-Carvalho M, Matos P, Jordan P.

RNA. 2014 Apr;20(4):474-82. doi: 10.1261/rna.041376.113. Epub 2014 Feb 18.

PMID:
24550521
[PubMed - indexed for MEDLINE]
8.

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.

Basavapathruni A, Olhava EJ, Daigle SR, Therkelsen CA, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Dovletoglou A, Richon VM, Pollock RM, Copeland RA, Moyer MP, Chesworth R, Pearson PG, Waters NJ.

Biopharm Drug Dispos. 2014 May;35(4):237-52. doi: 10.1002/bdd.1889. Epub 2014 Feb 14.

PMID:
24415392
[PubMed - in process]
9.

Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study.

Alcarraz-Vizán G, Sánchez-Tena S, Moyer MP, Cascante M.

Biochim Biophys Acta. 2014 Jun;1840(6):1634-9. doi: 10.1016/j.bbagen.2013.12.024. Epub 2013 Dec 22.

PMID:
24368265
[PubMed - indexed for MEDLINE]
10.

Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells.

Sanchez-Lopez E, Zimmerman T, Gomez del Pulgar T, Moyer MP, Lacal Sanjuan JC, Cebrian A.

Cell Death Dis. 2013 Nov 28;4:e933. doi: 10.1038/cddis.2013.453.

PMID:
24287694
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.

Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA.

Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26.

PMID:
23804703
[PubMed - indexed for MEDLINE]
12.

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.

Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM.

Blood. 2013 Aug 8;122(6):1017-25. doi: 10.1182/blood-2013-04-497644. Epub 2013 Jun 25.

PMID:
23801631
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.

Swalm BM, Hallenbeck KK, Majer CR, Jin L, Scott MP, Moyer MP, Copeland RA, Wigle TJ.

Biochem J. 2013 Jul 15;453(2):241-7. doi: 10.1042/BJ20130439.

PMID:
23679895
[PubMed - indexed for MEDLINE]
Free Article
14.

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

Knutson SK, Warholic NM, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Porter Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM, Kuntz KW, Keilhack H.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. doi: 10.1073/pnas.1303800110. Epub 2013 Apr 25.

PMID:
23620515
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.

Randhawa H, Kibble K, Zeng H, Moyer MP, Reindl KM.

Toxicol In Vitro. 2013 Sep;27(6):1626-33. doi: 10.1016/j.tiv.2013.04.006. Epub 2013 Apr 18.

PMID:
23603476
[PubMed - indexed for MEDLINE]
16.

Invasive colon cancer, but not non-invasive adenomas induce a gradient effect of Wnt pathway receptor frizzled 1 (Fz1) expression in the tumor microenvironment.

Planutis K, Planutiene M, Nguyen AV, Moyer MP, Holcombe RF.

J Transl Med. 2013 Feb 26;11:50. doi: 10.1186/1479-5876-11-50.

PMID:
23442549
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b.

Matos P, Kotelevets L, Goncalves V, Henriques A, Zerbib P, Moyer MP, Chastre E, Jordan P.

Neoplasia. 2013 Jan;15(1):102-11.

PMID:
23359345
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Targeting genetic alterations in protein methyltransferases for personalized cancer therapeutics.

Copeland RA, Moyer MP, Richon VM.

Oncogene. 2013 Feb 21;32(8):939-46. doi: 10.1038/onc.2012.552. Epub 2012 Nov 19. Review.

PMID:
23160372
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.

Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, Raimondi A, Majer CR, Song J, Scott MP, Jin L, Smith JJ, Olhava EJ, Chesworth R, Moyer MP, Richon VM, Copeland RA, Keilhack H, Pollock RM, Kuntz KW.

Nat Chem Biol. 2012 Nov;8(11):890-6. doi: 10.1038/nchembio.1084. Epub 2012 Sep 30.

PMID:
23023262
[PubMed - indexed for MEDLINE]
20.

IL-1β stimulation of CCD-18co myofibroblasts enhances repair of epithelial monolayers through Wnt-5a.

Raymond M, Marchbank T, Moyer MP, Playford RJ, Sanderson IR, Kruidenier L.

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1270-8. doi: 10.1152/ajpgi.00458.2011. Epub 2012 Sep 13.

PMID:
22982339
[PubMed - indexed for MEDLINE]
Free Article

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