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Results: 1 to 20 of 176

1.

Antioxidant capacity of broccoli sprouts subjected to gastrointestinal digestion.

Rychlik J, Olejnik A, Olkowicz M, Kowalska K, Juzwa W, Myszka K, Dembczyński R, Moyer MP, Grajek W.

J Sci Food Agric. 2014 Sep 3. doi: 10.1002/jsfa.6895. [Epub ahead of print]

PMID:
25186016
[PubMed - as supplied by publisher]
2.

Reaction Coupling between Wild-Type and Disease-Associated Mutant EZH2.

Swalm BM, Knutson SK, Warholic NM, Jin L, Kuntz KW, Keilhack H, Smith JJ, Pollock RM, Moyer MP, Scott MP, Copeland RA, Wigle TJ.

ACS Chem Biol. 2014 Aug 28. [Epub ahead of print]

PMID:
25154026
[PubMed - as supplied by publisher]
3.

A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells.

Sobradillo D, Hernández-Morales M, Ubierna D, Moyer MP, Núñez L, Villalobos C.

J Biol Chem. 2014 Aug 20. pii: jbc.M114.581678. [Epub ahead of print]

PMID:
25143380
[PubMed - as supplied by publisher]
Free Article
4.

DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.

Klaus CR, Iwanowicz D, Johnston D, Campbell CA, Smith JJ, Moyer MP, Copeland RA, Olhava EJ, Scott MP, Pollock RM, Daigle SR, Raimondi A.

J Pharmacol Exp Ther. 2014 Sep;350(3):646-56. doi: 10.1124/jpet.114.214577. Epub 2014 Jul 3.

PMID:
24993360
[PubMed - in process]
5.

DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism.

Skender B, Hofmanová J, Slavík J, Jelínková I, Machala M, Moyer MP, Kozubík A, Hyršlová Vaculová A.

Biochim Biophys Acta. 2014 Sep;1841(9):1308-17. doi: 10.1016/j.bbalip.2014.06.005. Epub 2014 Jun 19.

PMID:
24953781
[PubMed - indexed for MEDLINE]
6.

Integrated chemical and toxicological investigation of UV-chlorine/chloramine drinking water treatment.

Lyon BA, Milsk RY, DeAngelo AB, Simmons JE, Moyer MP, Weinberg HS.

Environ Sci Technol. 2014 Jun 17;48(12):6743-53. doi: 10.1021/es501412n. Epub 2014 Jun 4.

PMID:
24840005
[PubMed - in process]
7.

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.

Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.

Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.

PMID:
24735923
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.

Li N, Lee K, Xi Y, Zhu B, Gary BD, Ramírez-Alcántara V, Gurpinar E, Canzoneri JC, Fajardo A, Sigler S, Piazza JT, Chen X, Andrews J, Thomas M, Lu W, Li Y, Laan DJ, Moyer MP, Russo S, Eberhardt BT, Yet L, Keeton AB, Grizzle WE, Piazza GA.

Oncogene. 2014 Apr 7. doi: 10.1038/onc.2014.94. [Epub ahead of print]

PMID:
24704829
[PubMed - as supplied by publisher]
9.

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma.

Knutson SK, Kawano S, Minoshima Y, Warholic NM, Huang KC, Xiao Y, Kadowaki T, Uesugi M, Kuznetsov G, Kumar N, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Waters NJ, Smith JJ, Porter-Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Uenaka T, Pollock RM, Kuntz KW, Yokoi A, Keilhack H.

Mol Cancer Ther. 2014 Apr;13(4):842-54. doi: 10.1158/1535-7163.MCT-13-0773. Epub 2014 Feb 21.

PMID:
24563539
[PubMed - in process]
10.

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.

Gonçalves V, Henriques A, Pereira J, Neves Costa A, Moyer MP, Moita LF, Gama-Carvalho M, Matos P, Jordan P.

RNA. 2014 Apr;20(4):474-82. doi: 10.1261/rna.041376.113. Epub 2014 Feb 18.

PMID:
24550521
[PubMed - indexed for MEDLINE]
11.

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.

Basavapathruni A, Olhava EJ, Daigle SR, Therkelsen CA, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Dovletoglou A, Richon VM, Pollock RM, Copeland RA, Moyer MP, Chesworth R, Pearson PG, Waters NJ.

Biopharm Drug Dispos. 2014 May;35(4):237-52. doi: 10.1002/bdd.1889. Epub 2014 Feb 14.

PMID:
24415392
[PubMed - in process]
12.

Validation of NCM460 cell model as control in antitumor strategies targeting colon adenocarcinoma metabolic reprogramming: trichostatin A as a case study.

Alcarraz-Vizán G, Sánchez-Tena S, Moyer MP, Cascante M.

Biochim Biophys Acta. 2014 Jun;1840(6):1634-9. doi: 10.1016/j.bbagen.2013.12.024. Epub 2013 Dec 22.

PMID:
24368265
[PubMed - indexed for MEDLINE]
13.

Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells.

Sanchez-Lopez E, Zimmerman T, Gomez del Pulgar T, Moyer MP, Lacal Sanjuan JC, Cebrian A.

Cell Death Dis. 2013 Nov 28;4:e933. doi: 10.1038/cddis.2013.453.

PMID:
24287694
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.

Li N, Xi Y, Tinsley HN, Gurpinar E, Gary BD, Zhu B, Li Y, Chen X, Keeton AB, Abadi AH, Moyer MP, Grizzle WE, Chang WC, Clapper ML, Piazza GA.

Mol Cancer Ther. 2013 Sep;12(9):1848-59. doi: 10.1158/1535-7163.MCT-13-0048. Epub 2013 Jun 26.

PMID:
23804703
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.

Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM.

Blood. 2013 Aug 8;122(6):1017-25. doi: 10.1182/blood-2013-04-497644. Epub 2013 Jun 25.

PMID:
23801631
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.

Swalm BM, Hallenbeck KK, Majer CR, Jin L, Scott MP, Moyer MP, Copeland RA, Wigle TJ.

Biochem J. 2013 Jul 15;453(2):241-7. doi: 10.1042/BJ20130439.

PMID:
23679895
[PubMed - indexed for MEDLINE]
Free Article
17.

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

Knutson SK, Warholic NM, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Porter Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM, Kuntz KW, Keilhack H.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. doi: 10.1073/pnas.1303800110. Epub 2013 Apr 25.

PMID:
23620515
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.

Randhawa H, Kibble K, Zeng H, Moyer MP, Reindl KM.

Toxicol In Vitro. 2013 Sep;27(6):1626-33. doi: 10.1016/j.tiv.2013.04.006. Epub 2013 Apr 18.

PMID:
23603476
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Invasive colon cancer, but not non-invasive adenomas induce a gradient effect of Wnt pathway receptor frizzled 1 (Fz1) expression in the tumor microenvironment.

Planutis K, Planutiene M, Nguyen AV, Moyer MP, Holcombe RF.

J Transl Med. 2013 Feb 26;11:50. doi: 10.1186/1479-5876-11-50.

PMID:
23442549
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b.

Matos P, Kotelevets L, Goncalves V, Henriques A, Zerbib P, Moyer MP, Chastre E, Jordan P.

Neoplasia. 2013 Jan;15(1):102-11.

PMID:
23359345
[PubMed - indexed for MEDLINE]
Free PMC Article

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