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Items: 1 to 20 of 206

1.

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.

Duncan KW, Rioux N, Boriack-Sjodin PA, Munchhof MJ, Reiter LA, Majer CR, Jin L, Johnston LD, Chan-Penebre E, Kuplast KG, Porter Scott M, Pollock RM, Waters NJ, Smith JJ, Moyer MP, Copeland RA, Chesworth R.

ACS Med Chem Lett. 2015 Dec 2;7(2):162-6. doi: 10.1021/acsmedchemlett.5b00380. eCollection 2016 Feb 11.

PMID:
26985292
2.

N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro.

Beaumatin F, Dhaybi ME, Lasserre JP, Salin B, Moyer MP, Verdier M, Manon S, Priault M.

Oncotarget. 2016 Mar 6. doi: 10.18632/oncotarget.7938. [Epub ahead of print]

3.

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat.

Kuntz KW, Campbell JE, Keilhack H, Pollock RM, Knutson SK, Porter-Scott M, Richon VM, Sneeringer CJ, Wigle TJ, Allain CJ, Majer CR, Moyer MP, Copeland RA, Chesworth R.

J Med Chem. 2016 Feb 25;59(4):1556-64. doi: 10.1021/acs.jmedchem.5b01501. Epub 2016 Jan 27.

PMID:
26769278
4.

Corrigendum: Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.

Gonçalves V, Henriques AF, Pereira JF, Costa AN, Moyer MP, Moita LF, Gama-Carvalho M, Matos P, Jordan P.

RNA. 2016 Jan;22(1):166. doi: 10.1261/rna.055020.115. No abstract available.

5.

Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human.

Waters NJ, Smith SA, Olhava EJ, Duncan KW, Burton RD, O'Neill J, Rodrigue ME, Pollock RM, Moyer MP, Chesworth R.

Cancer Chemother Pharmacol. 2016 Jan;77(1):43-62. doi: 10.1007/s00280-015-2929-y. Epub 2015 Dec 8.

PMID:
26645404
6.

Gastrointestinal digested Sambucus nigra L. fruit extract protects in vitro cultured human colon cells against oxidative stress.

Olejnik A, Olkowicz M, Kowalska K, Rychlik J, Dembczyński R, Myszka K, Juzwa W, Białas W, Moyer MP.

Food Chem. 2016 Apr 15;197(Pt A):648-57. doi: 10.1016/j.foodchem.2015.11.017. Epub 2015 Nov 10.

PMID:
26616999
7.

A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer.

Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA.

J Biol Chem. 2016 Feb 19;291(8):4166-77. doi: 10.1074/jbc.M115.669416. Epub 2015 Nov 12.

PMID:
26565021
8.

Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.

Boriack-Sjodin PA, Jin L, Jacques SL, Drew A, Sneeringer C, Scott MP, Moyer MP, Ribich S, Moradei O, Copeland RA.

ACS Chem Biol. 2016 Mar 18;11(3):763-71. doi: 10.1021/acschembio.5b00773. Epub 2015 Nov 23.

PMID:
26551522
9.

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells.

Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer MP, Ehrmann J, Hyršlová Vaculová A.

PLoS One. 2015 Oct 22;10(10):e0141020. doi: 10.1371/journal.pone.0141020. eCollection 2015.

10.

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.

Alves S, Castro L, Fernandes MS, Francisco R, Castro P, Priault M, Chaves SR, Moyer MP, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A.

Oncotarget. 2015 Oct 13;6(31):30787-802. doi: 10.18632/oncotarget.5021.

11.

Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells.

Henriques AF, Barros P, Moyer MP, Matos P, Jordan P.

Cancer Lett. 2015 Dec 28;369(2):368-75. doi: 10.1016/j.canlet.2015.08.027. Epub 2015 Sep 1.

PMID:
26341689
12.

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.

Li N, Chen X, Zhu B, Ramírez-Alcántara V, Canzoneri JC, Lee K, Sigler S, Gary B, Li Y, Zhang W, Moyer MP, Salter EA, Wierzbicki A, Keeton AB, Piazza GA.

Oncotarget. 2015 Sep 29;6(29):27403-15. doi: 10.18632/oncotarget.4741.

13.

Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model.

Norbury KC, Moyer MP.

Mediators Inflamm. 2015;2015:419841. doi: 10.1155/2015/419841. Epub 2015 Jul 30.

14.

Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.

Rioux N, Duncan KW, Lantz RJ, Miao X, Chan-Penebre E, Moyer MP, Munchhof MJ, Copeland RA, Chesworth R, Waters NJ.

Xenobiotica. 2015 Aug 21:1-10. [Epub ahead of print]

PMID:
26294260
15.

Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.

Rioux N, Duncan KW, Lantz RJ, Miao X, Chan-Penebre E, Moyer MP, Munchhof MJ, Copeland RA, Chesworth R, Waters NJ.

Xenobiotica. 2015 Jul 31:1-10. [Epub ahead of print]

PMID:
26228443
16.

Antioxidant effects of gastrointestinal digested purple carrot extract on the human cells of colonic mucosa.

Olejnik A, Rychlik J, Kidoń M, Czapski J, Kowalska K, Juzwa W, Olkowicz M, Dembczyński R, Moyer MP.

Food Chem. 2016 Jan 1;190:1069-77. doi: 10.1016/j.foodchem.2015.06.080. Epub 2015 Jun 23.

PMID:
26213078
17.

Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.

Mitchell LH, Drew AE, Ribich SA, Rioux N, Swinger KK, Jacques SL, Lingaraj T, Boriack-Sjodin PA, Waters NJ, Wigle TJ, Moradei O, Jin L, Riera T, Porter-Scott M, Moyer MP, Smith JJ, Chesworth R, Copeland RA.

ACS Med Chem Lett. 2015 Apr 6;6(6):655-9. doi: 10.1021/acsmedchemlett.5b00071. eCollection 2015 Jun 11.

PMID:
26101569
18.

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells.

Amorim R, Pinheiro C, Miranda-Gonçalves V, Pereira H, Moyer MP, Preto A, Baltazar F.

Cancer Lett. 2015 Aug 28;365(1):68-78. doi: 10.1016/j.canlet.2015.05.015. Epub 2015 May 25.

PMID:
26021766
19.

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.

Campbell JE, Kuntz KW, Knutson SK, Warholic NM, Keilhack H, Wigle TJ, Raimondi A, Klaus CR, Rioux N, Yokoi A, Kawano S, Minoshima Y, Choi HW, Porter Scott M, Waters NJ, Smith JJ, Chesworth R, Moyer MP, Copeland RA.

ACS Med Chem Lett. 2015 Mar 4;6(5):491-5. doi: 10.1021/acsmedchemlett.5b00037. eCollection 2015 May 14.

PMID:
26005520
20.

Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α.

Ma Y, Yang Y, Wang F, Moyer MP, Wei Q, Zhang P, Yang Z, Liu W, Zhang H, Chen N, Wang H, Wang H, Qin H.

Gut. 2015 May 20. pii: gutjnl-2014-308392. doi: 10.1136/gutjnl-2014-308392. [Epub ahead of print]

PMID:
25994219
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