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Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.

Li H, Fu YX, Wu Q, Zhou Y, Crossman DK, Yang P, Li J, Luo B, Morel LM, Kabarowski JH, Yagita H, Ware CF, Hsu HC, Mountz JD.

J Clin Invest. 2015 Jul 1;125(7):2877-90. doi: 10.1172/JCI81059. Epub 2015 Jun 22.


Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases.

Hao L, Chen J, Zhu Z, Reddy MS, Mountz JD, Chen W, Li YP.

J Periodontol. 2015 Aug;86(8):972-83. doi: 10.1902/jop.2015.140643. Epub 2015 Apr 16.


The Dynamic Duo-Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases.

Li J, Hsu HC, Mountz JD.

J Orthop Rheumatol. 2013 Nov 1;1(1):4.


Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus.

Sang A, Zheng YY, Yin Y, Dozmorov I, Li H, Hsu HC, Mountz JD, Morel L.

PLoS One. 2014 Aug 5;9(8):e102151. doi: 10.1371/journal.pone.0102151. eCollection 2014.


IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt.

Li H, Hsu HC, Wu Q, Yang P, Li J, Luo B, Oukka M, Steele CH 3rd, Cua DJ, Grizzle WE, Mountz JD.

Nat Commun. 2014 Jul 8;5:4259. doi: 10.1038/ncomms5259.


Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.

Ding Y, Li J, Yang P, Luo B, Wu Q, Zajac AJ, Wildner O, Hsu HC, Mountz JD.

Arthritis Rheumatol. 2014 Sep;66(9):2601-12. doi: 10.1002/art.38735.


Inhibition of fucosylation reshapes inflammatory macrophages and suppresses type II collagen-induced arthritis.

Li J, Hsu HC, Ding Y, Li H, Wu Q, Yang P, Luo B, Rowse AL, Spalding DM, Bridges SL Jr, Mountz JD.

Arthritis Rheumatol. 2014 Sep;66(9):2368-79. doi: 10.1002/art.38711.


Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction.

Yang S, Hao L, McConnell M, Zhou X, Wang M, Zhang Y, Mountz JD, Reddy M, Eleazer PD, Li YP, Chen W.

Bone Res. 2013 Sep 1;1(3):267-281.


The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis.

Naves R, Singh SP, Cashman KS, Rowse AL, Axtell RC, Steinman L, Mountz JD, Steele C, De Sarno P, Raman C.

J Immunol. 2013 Sep 15;191(6):2967-77. doi: 10.4049/jimmunol.1300419. Epub 2013 Aug 19.


IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells.

Ding Y, Li J, Wu Q, Yang P, Luo B, Xie S, Druey KM, Zajac AJ, Hsu HC, Mountz JD.

J Immunol. 2013 Aug 15;191(4):1614-24. doi: 10.4049/jimmunol.1300479. Epub 2013 Jul 15.


Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice.

Wang JH, New JS, Xie S, Yang P, Wu Q, Li J, Luo B, Ding Y, Druey KM, Hsu HC, Mountz JD.

Arthritis Rheum. 2013 Oct;65(10):2703-12. doi: 10.1002/art.38059.


Death receptor 5-targeted depletion of interleukin-23-producing macrophages, Th17, and Th1/17 associated with defective tyrosine phosphatase in mice and patients with rheumatoid arthritis.

Li J, Yang P, Wu Q, Li H, Ding Y, Hsu HC, Spalding DM, Mountz JD.

Arthritis Rheum. 2013 Oct;65(10):2594-605. doi: 10.1002/art.38057.


Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.

Hwang YG, Hsu HC, Lim FC, Wu Q, Yang P, Fisher G, Hunter GR, Mountz JD.

Adv Aging Res. 2013 May;2(2):72-80.


Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.

Li H, Wu Q, Li J, Yang P, Zhu Z, Luo B, Hsu HC, Mountz JD.

J Immunol. 2013 May 1;190(9):4465-9. doi: 10.4049/jimmunol.1300041. Epub 2013 Mar 29.


Managing macrophages in rheumatoid arthritis by reform or removal.

Li J, Hsu HC, Mountz JD.

Curr Rheumatol Rep. 2012 Oct;14(5):445-54. doi: 10.1007/s11926-012-0272-4. Review.


Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model.

Li J, Hsu HC, Yang P, Wu Q, Li H, Edgington LE, Bogyo M, Kimberly RP, Mountz JD.

Arthritis Rheum. 2012 Apr;64(4):1098-109. doi: 10.1002/art.33423. Epub 2011 Oct 13.


Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)-transduced monocyte-derived killer-dendritic cells.

Schütz C, Hoves S, Halbritter D, Zhang HG, Mountz JD, Fleck M.

Immunology. 2011 May;133(1):115-22. doi: 10.1111/j.1365-2567.2011.03417.x. Epub 2011 Feb 22.


Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.

Hsu HC, Yang P, Wu Q, Wang JH, Job G, Guentert T, Li J, Stockard CR, Le TV, Chaplin DD, Grizzle WE, Mountz JD.

Arthritis Rheum. 2011 Jul;63(7):2038-48. doi: 10.1002/art.30257.


Type I interferon-dependent CD86(high) marginal zone precursor B cells are potent T cell costimulators in mice.

Wang JH, Wu Q, Yang P, Li H, Li J, Mountz JD, Hsu HC.

Arthritis Rheum. 2011 Apr;63(4):1054-64. doi: 10.1002/art.30231.

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