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Items: 1 to 20 of 36

1.

Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Inhibition During Sepsis Dampens the Early Systemic Inflammatory Response.

Hayes AJ, Mole DJ.

Crit Care Med. 2016 Aug;44(8):1628-9. doi: 10.1097/CCM.0000000000001752. No abstract available.

PMID:
27428133
2.

Identifying risk factors for progression to critical care admission and death among individuals with acute pancreatitis: a record linkage analysis of Scottish healthcare databases.

Mole DJ, Gungabissoon U, Johnston P, Cochrane L, Hopkins L, Wyper GM, Skouras C, Dibben C, Sullivan F, Morris A, Ward HJ, Lawton AM, Donnan PT.

BMJ Open. 2016 Jun 15;6(6):e011474. doi: 10.1136/bmjopen-2016-011474.

3.

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback.

Wilson K, Auer M, Binnie M, Zheng X, Pham NT, Iredale JP, Webster SP, Mole DJ.

Cell Death Dis. 2016 Apr 14;7:e2197. doi: 10.1038/cddis.2016.87.

4.

Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.

PMID:
26989254
5.

Lung ultrasonography as a direct measure of evolving respiratory dysfunction and disease severity in patients with acute pancreatitis.

Skouras C, Davis ZA, Sharkey J, Parks RW, Garden OJ, Murchison JT, Mole DJ.

HPB (Oxford). 2016 Feb;18(2):159-69. doi: 10.1016/j.hpb.2015.10.002. Epub 2015 Nov 18.

6.

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.

Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.

7.

Lung ultrasonography as a direct measure of evolving respiratory dysfunction and disease severity in patients with acute pancreatitis.

Skouras C, Davis ZA, Sharkey J, Parks RW, Garden JO, Murchison JT, Mole DJ.

HPB (Oxford). 2015 Oct 16. doi: 10.1111/hpb.12515. [Epub ahead of print]

PMID:
26474108
8.

A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.

Wilson K, Mole DJ, Homer NZ, Iredale JP, Auer M, Webster SP.

J Biomol Screen. 2015 Feb;20(2):292-8. doi: 10.1177/1087057114554171. Epub 2014 Oct 8.

PMID:
25296660
9.

The intestinal mucus layer is a critical component of the gut barrier that is damaged during acute pancreatitis.

Fishman JE, Levy G, Alli V, Zheng X, Mole DJ, Deitch EA.

Shock. 2014 Sep;42(3):264-70. doi: 10.1097/SHK.0000000000000209.

10.

Early organ dysfunction affects long-term survival in acute pancreatitis patients.

Skouras C, Hayes AJ, Williams L, Garden OJ, Parks RW, Mole DJ.

HPB (Oxford). 2014 Sep;16(9):789-96. doi: 10.1111/hpb.12259. Epub 2014 Apr 9.

11.

Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometry.

Lowe DM, Gee M, Haslam C, Leavens B, Christodoulou E, Hissey P, Hardwicke P, Argyrou A, Webster SP, Mole DJ, Wilson K, Binnie M, Yard BA, Dean T, Liddle J, Uings I, Hutchinson JP.

J Biomol Screen. 2014 Apr;19(4):508-15. doi: 10.1177/1087057113518069. Epub 2013 Dec 31.

PMID:
24381207
12.

Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.

Wilson K, Mole DJ, Binnie M, Homer NZ, Zheng X, Yard BA, Iredale JP, Auer M, Webster SP.

Protein Expr Purif. 2014 Mar;95:96-103. doi: 10.1016/j.pep.2013.11.015. Epub 2013 Dec 4.

13.

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.

Fallowfield JA, Hayden AL, Snowdon VK, Aucott RL, Stutchfield BM, Mole DJ, Pellicoro A, Gordon-Walker TT, Henke A, Schrader J, Trivedi PJ, Princivalle M, Forbes SJ, Collins JE, Iredale JP.

Hepatology. 2014 Apr;59(4):1492-504. doi: 10.1002/hep.26627. Epub 2014 Mar 3.

PMID:
23873655
14.

[International multidisciplinary classification of acute pancreatitis severity: the 2013 Spanish edition].

Maraví-Poma E, Patchen Dellinger E, Forsmark CE, Layer P, Lévy P, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS; Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA).

Med Intensiva. 2014 May;38(4):211-7. doi: 10.1016/j.medin.2013.03.013. Epub 2013 Jun 7. Spanish.

15.

[Determinant-based classification of acute pancreatitis severity. International multidisciplinary classification of acute pancreatitis severity: the 2013 German edition].

Layer P, Dellinger EP, Forsmark CE, Lévy P, Maraví-Poma E, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS; Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA).

Z Gastroenterol. 2013 Jun;51(6):544-50. doi: 10.1055/s-0033-1335526. Epub 2013 Jun 5. Review. German.

PMID:
23740353
16.

Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation.

Dellinger EP, Forsmark CE, Layer P, Lévy P, Maraví-Poma E, Petrov MS, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA; Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA).

Ann Surg. 2012 Dec;256(6):875-80. doi: 10.1097/SLA.0b013e318256f778.

PMID:
22735715
17.

Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.

Mole DJ, O'Neill C, Hamilton P, Olabi B, Robinson V, Williams L, Diamond T, El-Tanani M, Campbell FC.

Br J Cancer. 2011 Mar 15;104(6):1007-12. doi: 10.1038/bjc.2011.33. Epub 2011 Feb 22.

18.

Detailed fluid resuscitation profiles in patients with severe acute pancreatitis.

Mole DJ, Hall A, McKeown D, Garden OJ, Parks RW.

HPB (Oxford). 2011 Jan;13(1):51-8. doi: 10.1111/j.1477-2574.2010.00241.x. Epub 2010 Nov 15.

19.

Once bitten, twice shy: defective monocyte signaling in acute pancreatitis.

McGregor RJ, Mole DJ.

Crit Care Med. 2010 Aug;38(8):1751-2. doi: 10.1097/CCM.0b013e3181e8787c. No abstract available.

PMID:
20647806
20.

Management of liver trauma.

Badger SA, Barclay R, Campbell P, Mole DJ, Diamond T.

World J Surg. 2009 Dec;33(12):2522-37. doi: 10.1007/s00268-009-0215-z. Review.

PMID:
19760312
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