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Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.

Chapman VL, Terranova R, Moggs JG, Kimber I, Dearman RJ.

Toxicology. 2016 Jan 18;340:17-26. doi: 10.1016/j.tox.2015.12.003. Epub 2015 Dec 28.


Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.

Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K.

Toxicology. 2015 Sep 1;335:11-9. doi: 10.1016/j.tox.2015.06.009. Epub 2015 Jun 29.


Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.

Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2014 Jun;139(2):501-11. doi: 10.1093/toxsci/kfu038. Epub 2014 Apr 1.


Retro-orbital blood acquisition facilitates circulating microRNA measurement in zebrafish with paracetamol hepatotoxicity.

Vliegenthart AD, Starkey Lewis P, Tucker CS, Del Pozo J, Rider S, Antoine DJ, Dubost V, Westphal M, Moulin P, Bailey MA, Moggs JG, Goldring CE, Park BK, Dear JW.

Zebrafish. 2014 Jun;11(3):219-26. doi: 10.1089/zeb.2013.0912. Epub 2014 Mar 13.


Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques.

Thomson JP, Hunter JM, Nestor CE, Dunican DS, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Dec;41(22):e206. doi: 10.1093/nar/gkt1080. Epub 2013 Nov 7. Erratum in: Nucleic Acids Res. . 2014 Apr;42(6):4142.


Epigenetic profiles as defined signatures of xenobiotic exposure.

Thomson JP, Moggs JG, Wolf CR, Meehan RR.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:3-9. doi: 10.1016/j.mrgentox.2013.08.007. Epub 2013 Aug 31. Review.


Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

Thomson JP, Hunter JM, Lempiäinen H, Müller A, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Jun;41(11):5639-54. doi: 10.1093/nar/gkt232. Epub 2013 Apr 17.


Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital.

Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK.

Hepatology. 2013 Aug;58(2):777-87. doi: 10.1002/hep.26294. Epub 2013 Jul 2.


Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions.

Vacchi-Suzzi C, Hahne F, Scheubel P, Marcellin M, Dubost V, Westphal M, Boeglen C, Büchmann-Møller S, Cheung MS, Cordier A, De Benedetto C, Deurinck M, Frei M, Moulin P, Oakeley E, Grenet O, Grevot A, Stull R, Theil D, Moggs JG, Marrer E, Couttet P.

PLoS One. 2013;8(1):e52442. doi: 10.1371/journal.pone.0052442. Epub 2013 Jan 2.


Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.

Lempiäinen H, Couttet P, Bolognani F, Müller A, Dubost V, Luisier R, Del Rio Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Längle U, Scheer N, Schübeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2013 Feb;131(2):375-86. doi: 10.1093/toxsci/kfs303. Epub 2012 Oct 22.


Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR.

Genome Biol. 2012 Oct 3;13(10):R93. doi: 10.1186/gb-2012-13-10-r93.


Serum microRNA biomarkers for drug-induced liver injury.

Starkey Lewis PJ, Merz M, Couttet P, Grenet O, Dear J, Antoine DJ, Goldring C, Park BK, Moggs JG.

Clin Pharmacol Ther. 2012 Sep;92(3):291-3. doi: 10.1038/clpt.2012.101. Epub 2012 Jul 25. Review.


Regulation of allergic responses to chemicals and drugs: possible roles of epigenetic mechanisms.

Moggs JG, Terranova R, Kammüller ME, Chibout SD, Chapman V, Dearman RJ, Kimber I.

Toxicol Sci. 2012 Nov;130(1):60-9. doi: 10.1093/toxsci/kfs207. Epub 2012 Jun 15. Review.


Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.

Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, Rusyn I.

Toxicol Sci. 2007 Sep;99(1):315-25. Epub 2007 Jun 8.


Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review.

Lim FL, Currie RA, Orphanides G, Moggs JG.

Xenobiotica. 2006 Oct-Nov;36(10-11):1140-51. Review.


Identification of early molecular pathways affected by paraquat in rat lung.

Mainwaring G, Lim FL, Antrobus K, Swain C, Clapp M, Kimber I, Orphanides G, Moggs JG.

Toxicology. 2006 Aug 15;225(2-3):157-72. Epub 2006 Jun 6.


Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.

Stuckey R, Aldridge T, Lim FL, Moore DJ, Tinwell H, Doherty N, Davies R, Smith AG, Kimber I, Ashby J, Orphanides G, Moggs JG.

Mol Cell Endocrinol. 2006 Jul 11;253(1-2):22-9. Epub 2006 May 8.


Proteomic analysis of suction blister fluid isolated from human skin.

Macdonald N, Cumberbatch M, Singh M, Moggs JG, Orphanides G, Dearman RJ, Griffiths CE, Kimber I.

Clin Exp Dermatol. 2006 May;31(3):445-8.


Analysis of DNA repair and chromatin assembly in vitro using immobilized damaged DNA substrates.

Mello JA, Moggs JG, Almouzni G.

Methods Mol Biol. 2006;314:477-87.


Assaying for the dual incisions of nucleotide excision repair using DNA with a lesion at a specific site.

Shivji MK, Moggs JG, Kuraoka I, Wood RD.

Methods Mol Biol. 2006;314:435-56.

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